An immune-inflamed tumor microenvironment as defined by CD8 score is associated with favorable oncologic outcomes in hepatocellular carcinoma independent of measures of tumor mutational burden

Autor: Cherkassky, Leonid, Oshi, Masanori, Abdelfatah, Eihab, Wu, Rongrong, Takabe, Yamato, Yan, Li, Endo, Itaru, Takabe, Kazuaki

Publikováno v: Am J Cancer Res

Despite low mutational burden, immune checkpoint inhibitors have demonstrated promising results in a significant minority of hepatocellular carcinoma (HCC) patients with advanced disease. We hypothesized that HCC patients with higher levels of CD8+ T

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https://europepmc.org/articles/PMC9360211/

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An immune-inflamed tumor microenvironment as defined by CD8 score is associated with favorable oncologic outcomes in hepatocellular carcinoma independent of measures of tumor mutational burden.

Autor: Cherkassky L; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA., Oshi M; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA.; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University Yokohama 236-0004, Japan., Abdelfatah E; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA., Wu R; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA., Takabe Y; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA., Yan L; Department of Biostatistics & Bioinformatics, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA., Endo I; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University Yokohama 236-0004, Japan., Takabe K; Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14203, USA.; Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University Yokohama 236-0004, Japan.; Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, State University of New York Buffalo, NY 14263, USA.; Department of Breast Surgery and Oncology, Tokyo Medical University Tokyo 160-8402, Japan.; Department of Digestive and General Surgery, Graduate School of Medicine and Dental Sciences, Niigata University Niigata 951-8520, Japan.; Department of Breast Surgery, School of Medicine, Fukushima Medical University Fukushima 960-1295, Japan.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2022 Jul 15; Vol. 12 (7), pp. 3099-3110. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).