Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Takaaki Ohtake"'
Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.
Autor:
Yosuke Osawa, Hironari Kawai, Keigo Nakashima, Yuichi Nakaseko, Daisuke Suto, Keisuke Yanagida, Tomomi Hashidate-Yoshida, Taizo Mori, Sachiyo Yoshio, Takaaki Ohtake, Hideo Shindou, Tatsuya Kanto
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303296 (2024)
AimMetabolic dysfunction-associated steatohepatitis (MASH) is one of the most prevalent liver diseases and is characterized by steatosis and the accumulation of bioactive lipids. This study aims to understand the specific lipid species responsible fo
Externí odkaz:
https://doaj.org/article/a39a40adb53b45e78a3e925d9fbcd021
Autor:
Wataru Jomen, Takaaki Ohtake, Takayuki Akita, Daisuke Suto, Hideki Yagi, Yosuke Osawa, Yutaka Kohgo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113363- (2022)
Objective: The improvements of antitumor effects and tolerability on chemotherapy for advanced hepatocellular carcinoma (HCC) are warranted. Here, we aimed to elucidate the mechanism of the combining effect of tyrosine kinase inhibitor sorafenib (SOR
Externí odkaz:
https://doaj.org/article/f0f08e4e5e1e4a53a32c2550aaef7570
Autor:
Yosuke Osawa, Yuichi Nakaseko, Keigo Nakashima, Daisuke Suto, Hironori Odaira, Yutaka Kohgo, Yutaka Suzuki, Takaaki Ohtake
Publikováno v:
Internal Medicine. 62:1005-1009
Autor:
Yosuke Osawa, Takaaki Ohtake, Daisuke Suto, Takayuki Akita, Hidehiko Yamada, Yutaka Kohgo, Kazumoto Murata
Publikováno v:
Internal medicine (Tokyo, Japan). 62(1)
Objective One of the therapeutic goals for chronic infection with hepatitis B virus is the clearance of hepatitis B surface antigen (HBsAg) from the blood, as a high load of HBsAg has been proposed to induce antigen-specific immunotolerance. To achie
Autor:
Hirotaka Arai, Atsushi Naganuma, Takeshi Nihei, Tadashi Ikegami, Hidekazu Kurata, Takaaki Ohtake, Toshiyuki Tahara, Kouichi Miura, Katsuhiko Horiuchi, Ken Sato, Satoru Kakizaki, Shigeo Tano, Toshiro Kamoshida, Norio Isoda, Yukimura Fukaya, Atsuko Soeda, Makoto Iijima, Toshiya Ohtake, Takeharu Asano, Takeshi Hatanaka, Masashi Namikawa, Takeshi Fujieda, Naoki Morimoto, Shunji Watanabe, Takashi Ueno, Takashi Kosone, Toshimitsu Murohisa, Hironori Yamamoto, Yoshinari Takaoka
Publikováno v:
Hepatology Research. 51:51-61
AIM This study aimed to evaluate the real-world efficacy and safety of 12-week sofosbuvir/velpatasvir (SOF/VEL) treatment for patients with decompensated liver cirrhosis caused by hepatitis C virus (HCV) infection. METHODS A total 72 of patients with
Autor:
Yosuke Osawa, Takaaki Ohtake, Daisuke Suto, Takayuki Akita, Hidehiko Yamada, Yutaka Kohgo, Kazumoto Murata
Publikováno v:
Internal Medicine; 2023, Vol. 62 Issue 1, p51-57, 7p
Autor:
Shunji Watanabe, Atsushi Naganuma, Tadashi Ikegami, Rie Goka, Hiroaki Nomoto, Takaaki Ohtake, Yoshinari Takaoka, Hirotaka Arai, Naoto Sato, Masashi Namikawa, Takashi Ueno, Toshiro Kamoshida, Hiroshi Maeda, Mamiko Tsukui, Norio Isoda, Hironori Yamamoto, Shigeo Tano, Takashi Kosone, Yukimura Fukaya, Takuya Hirosawa, Satoru Kakizaki, Kouichi Miura, Naoki Morimoto, Katsuhiko Horiuchi, Takeharu Asano, Takeshi Hatanaka, Toshimitsu Murohisa, Toshiyuki Tahara
Publikováno v:
Kanzo. 61:276-278
Autor:
Masayasu Naito, Seiichiro Hoshino, Tatsuyuki Tonan, Takuji Torimura, Takaaki Ohtake, Toshikatsu Okumura, Takumi Kawaguchi, Hisao Hayashi, Koichi Kato, Yasuaki Tatsumi, Yasumichi Toki, Katsuya Ikuta
Publikováno v:
Hepatology Research. 50:144-150
Juvenile hemochromatosis (JH) is known as a progressive iron-storage disease, and causes severe organ impairments, including cardiomyopathy and liver cirrhosis. However, JH is a rare genetic disorder, and information for genetic mutations and phenoty
Autor:
Akinobu Kato, Ryujin Endo, Ryuta Shigefuku, Daiki Habu, Akiko Eguchi, Kazuyuki Suzuki, Kazutomo Suzuki, Makoto Shiraki, Takaaki Ohtake, Kazuhiro Katayama, Motoh Iwasa, Koichi Shiraishi, Naohiro Kawamura, Hisataka Moriwaki, Shuhei Nishiguchi, Takumi Kawaguchi, Chizu Koreeda, Yoshio Tokumoto, Yoshiyuki Takei, Hironori Sakai, Toshifumi Ito
Publikováno v:
Hepatology Research. 49:1127-1135
Aim Hypozincemia is associated with the progression of chronic liver diseases, but it is unknown whether hypozincemia promotes human hepatocarcinogenesis. Our aim is to evaluate the serum zinc levels in liver cirrhosis (LC) patients and clarify the r
Publikováno v:
Vitamins and hormones. 110
Hepcidin is a main regulator of iron metabolism, of which abnormal expression affects intestinal absorption and reticuloendothelial sequestration of iron by interacting with ferroportin. It is also noted that abnormal iron accumulation is one of the