Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Takaaki Ikemoto"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 93, Iss 3, Pp 279-288 (2003)
ABSTRACT: We analyzed the effect of HMG-CoA reductase inhibitors on Ca2+ release from the sarcoplasmic reticulum (SR) using chemically skinned skeletal muscle fibers from the mouse and the rat. Cerivastatin (>20 μM) released Ca2+ from the SR, while
Externí odkaz:
https://doaj.org/article/de98f2c9af3c4cc6b4e9d1d7285b6d76
Publikováno v:
Muscle & Nerve. 49:728-735
Introduction: α1-syntrophin, a member of the dystrophin complex, recruits membrane molecules, including aquaporin-4, at the sarcolemma. The physiological functions of α1-syntrophin are poorly understood. Methods: We examined the physiological chara
Autor:
Hiroshi Aoyama, Toshiyuki Hiramatsu, Takamitsu Hosoya, Makoto Endo, Kumi Takata, Masaaki Suzuki, Takaaki Ikemoto, Hirotaka Onoe
Publikováno v:
Diabetes
OBJECTIVE In skeletal muscles, dantrolene inhibits the exercise-induced membrane translocation of GLUT4. It has been postulated that the inhibitory action of dantrolene on Ca2+ release from the sarcoplasmic reticulum (SR) causes inhibition of exercis
Autor:
Takamitsu Hosoya, Hiroshi Aoyama, Takaaki Ikemoto, Masaaki Suzuki, Makoto Endo, Tatsuro Ohmae, Toshiyuki Hiramatsu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1289-1294
Bifunctional dantrolene derivatives have been synthesized as probes for radioisotope-free photoaffinity labeling with the aim of elucidating the molecular mechanism of skeletal muscle contraction. GIF-0430 and GIF-0665 are aromatic azido-functionaliz
Autor:
Takaaki Ikemoto, Makoto Endo
Publikováno v:
British Journal of Pharmacology. 134:719-728
1. To characterize the effect of clofibric acid (Clof) on the Ca(2+) release mechanism in the sarcoplasmic reticulum (SR) of skeletal muscle, we analysed the properties of Clof-induced Ca(2+) release under various conditions using chemically skinned
Autor:
Makoto Endo, Masaaki Suzuki, Hiroshi Aoyama, Yasutaka Kihara, Takamitsu Hosoya, Takaaki Ikemoto
Publikováno v:
British Journal of Pharmacology. 134:729-736
1. We analysed the effect of dantrolene (Dan) and five newly synthesized derivatives (GIFs) on Ca(2+) release from the sarcoplasmic reticulum (SR) of mouse skeletal muscle. 2. In intact muscles, GIF-0185 reduced the size of twitch contraction induced
Autor:
Takaaki Ikemoto, Tetsuo Noda, Makoto Endo, Hiroshi Takeshima, Miyuki Nishi, Shinji Komazaki, Masamitsu Iino
Publikováno v:
The Journal of Physiology. 501:305-312
1 We generated mice with targeted disruptions in the genes for both ryanodine receptor type 1 (RyR-1) and type 3 (RyR-3) to study the functional roles of RyR subtypes in skeletal muscle. 2 In permeabilized myocytes lacking both the RyRs, the Ca2+-ind
Publikováno v:
British Journal of Pharmacology. 118:690-694
1. Calmodulin (CaM) has a biphasic effect on Ca(2+)-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR): potentiation and inhibition at low (pCa > 6.0) and high (pCa 5) Ca2+ concentrations, respectively. To characterize the mode of actio
Autor:
Toshifumi, Yokota, Yuko, Miyagoe-Suzuki, Takaaki, Ikemoto, Ryoichi, Matsuda, Shin'ichi, Takeda
Publikováno v:
Musclenerve. 49(5)
α1-syntrophin, a member of the dystrophin complex, recruits membrane molecules, including aquaporin-4, at the sarcolemma. The physiological functions of α1-syntrophin are poorly understood.We examined the physiological characteristics of α1-syntro
Autor:
Masamitsu Iino, Toshiko Yamazawa, Takaaki Ikemoto, Hiroaki Takekura, Miyuki Nishi, Tetsuo Noda, Hiroshi Takeshima
Publikováno v:
The EMBO Journal. 14:2999-3006
While subtypes 1 and 2 of the ryanodine receptor (RyR) function as intracellular Ca2+ release channels, little is known about the function of the third subtype (RyR-3), first identified in brain. Myocytes from mice homozygous for a targeted mutation