Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Takaaki, Sumiyoshi"'
Autor:
Haomin Yan, Tsutomu Sasaki, Hideaki Kanki, Yoshiyuki Hirata, Kumiko Nishiyama, Sunao Hisada, Shigenobu Matsumura, Yasuo Nagaoka, Takaaki Sumiyoshi, Seiichi Nagano, Akiko Nakata, Minoru Yoshida, Shinichi Uesato, Hideki Mochizuki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Mdmx and Mdm2 are two major suppressor factors for the tumor suppressor gene p53. In central nervous system, Mdmx suppresses the transcriptional activity of p53 and enhances the binding of Mdm2 to p53 for degradation. But Mdmx dynamics in ce
Externí odkaz:
https://doaj.org/article/d535ef55554745bdb1de765b94ef736c
Autor:
Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1683 (2022)
A proton-coupled organic cation (H+/OC) antiporter working at the blood–brain barrier (BBB) in humans and rodents is thought to be a promising candidate for the efficient delivery of cationic drugs to the brain. Therefore, it is important to identi
Externí odkaz:
https://doaj.org/article/946ddae06db648bb9cfcbb6d68310c91
Autor:
Kosuke Hashimoto, Soichiro Ide, Mayumi Arata, Akiko Nakata, Akihiro Ito, Takashi K. Ito, Norio Kudo, Bangzhong Lin, Kazuto Nunomura, Keiko Tsuganezawa, Minoru Yoshida, Yasuo Nagaoka, Takaaki Sumiyoshi
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1077-1082
Inhibition of histone deacetylase 6 (HDAC6) in the brain is a highly attractive therapeutic target for the treatment of neurodegenerative diseases. The low blood-brain barrier permeability of most known HDAC6 inhibitors, however, prevents their appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb23750dd43ddb2ac7e5fecf8a006213
https://doi.org/10.1021/acsmedchemlett.2c00081
https://doi.org/10.1021/acsmedchemlett.2c00081
Autor:
Shintaro Kitayama, Mizuki Nagai, Yasuo Nagaoka, Ippei Horibe, Ayaka Nakai, Takaaki Sumiyoshi, Yuri Kokuwano
Publikováno v:
Journal of Society of Cosmetic Chemists of Japan. 54:169-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0304a366b7d387abf4b17874282e5123
https://doi.org/10.5107/sccj.54.169
https://doi.org/10.5107/sccj.54.169
Autor:
Norie Tsuboya, Masanori Tobe, Tomoko Nakajima, Kazumi Niidome, Masato Sakamoto, Kengo Tojo, Daisuke Urabe, Takaaki Sumiyoshi
Publikováno v:
Molecules, Vol 17, Iss 6, Pp 6507-6518 (2012)
We describe in this study the asymmetric synthesis of radioisotope (RI)-labeled selective glucocorticoid receptor modulator. This synthesis is based on optimization of the cinchona alkaloid catalyzed addition of 6-bromoindole to ethyl trifluoropyruva
Externí odkaz:
https://doaj.org/article/79f7caab5cf24be3b16326e0a5063007
Publikováno v:
The Journal of General and Applied Microbiology. 66:265-272
The degradation pathways in microorganisms for piperidine, a secondary amine with various applications, are not yet fully understood, especially in non-Mycobacterium species. In this study, we have identified a piperidine-degrading isolate (KU43P) fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced962e1c273340921818d15518b15f0
https://doi.org/10.2323/jgam.2019.11.006
https://doi.org/10.2323/jgam.2019.11.006
Autor:
Takaaki Sumiyoshi, Nozomi Kazama, Takeshi Ito, Naoto Asai, Tomohiro Shimizu, Yasuo Nagaoka, Shoso Shingubara, Naohiro Matsumoto
Publikováno v:
IEEE Sensors Journal. 19:4025-4030
An anodic aluminon oxide-based nano-honeycomb electrode was fabricated on a quartz crystal to increase the surface area binding with an analyte for using as a sensing device in a quartz crystal microbalance to monitor the protein–protein interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::055bb74c5b735eb3653ada3262d7a4e8
https://doi.org/10.1109/jsen.2019.2898408
https://doi.org/10.1109/jsen.2019.2898408
Publikováno v:
Chemical Biology & Drug Design. 93:657-665
Drug design using boron-containing heterocycles has attracted a great deal of attention because these compounds are believed to possess high biological activity. However, information on the synthetic methodology and pharmacokinetic profiling of boron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bfce37432d0dd5f11b0ae026b4c3f9
https://doi.org/10.1111/cbdd.13496
https://doi.org/10.1111/cbdd.13496
Publikováno v:
Biochemical and biophysical research communications. 530(2)
Activated hepatic stellate cells (HSCs) play a central role in fibrillary collagen production, the primary cause of liver fibrosis. Although it is known that primary cultured HSCs are activated by plastic culture dish stiffness, HSC activation and qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6291d8bc2dc95e7e76d837b968c2f15f
https://pubmed.ncbi.nlm.nih.gov/32798017
https://pubmed.ncbi.nlm.nih.gov/32798017
Publikováno v:
The Journal of general and applied microbiology. 66(5)
The degradation pathways in microorganisms for piperidine, a secondary amine with various applications, are not yet fully understood, especially in non-Mycobacterium species. In this study, we have identified a piperidine-degrading isolate (KU43P) fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::325bd8f07cd7bb87290109e72fb0a172
https://pubmed.ncbi.nlm.nih.gov/32641635
https://pubmed.ncbi.nlm.nih.gov/32641635