Multi-omics and clustering analyses reveal the mechanisms underlying unmet needs for patients with lung adenocarcinoma and identify potential therapeutic targets

Autor: Ken Asada, Syuzo Kaneko, Ken Takasawa, Kouya Shiraishi, Norio Shinkai, Yoko Shimada, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Amina Bolatkan, Masaaki Komatsu, Masayoshi Yamada, Mototaka Miyake, Hirokazu Watanabe, Akiko Tateishi, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto

Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-9 (2024)

Abstract Background The cancer genome contains several driver mutations. However, in some cases, no known drivers have been identified; these remaining areas of unmet needs, leading to limited progress in cancer therapy. Whole-genome sequencing (WGS)

Externí odkaz: https://doaj.org/article/5ca317bc30aa4ff796701baac2c9a5a6

Advances in cancer DNA methylation analysis with methPLIER: use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability

Autor: Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 3, Pp 646-655 (2024)

Abstract DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. DNA methylation patterns regulate gene expression and have been widely researched. While tools for DNA methylation ana

Externí odkaz: https://doaj.org/article/0a8c89ddfeac4cf8b4c8994da7107c71

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses

Autor: Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, Syuzo Kaneko, Takahisa Kawaguchi, Hideo Kunitoh, Shingo Matsumoto, Hidehito Horinouchi, Akiteru Goto, Takayuki Honda, Kimihiro Shimizu, Masahiro Torasawa, Daisuke Takayanagi, Motonobu Saito, Akira Saito, Yuichiro Ohe, Shun‐ichi Watanabe, Koichi Goto, Masahiro Tsuboi, Katsuya Tsuchihara, Sadaaki Takata, Tomomi Aoi, Atsushi Takano, Masashi Kobayashi, Yohei Miyagi, Kazumi Tanaka, Hiroyuki Suzuki, Daichi Maeda, Takumi Yamaura, Maiko Matsuda, Yoko Shimada, Takaaki Mizuno, Hiromi Sakamoto, Teruhiko Yoshida, Yasushi Goto, Tatsuya Yoshida, Taiki Yamaji, Makoto Sonobe, Shinichi Toyooka, Kazue Yoneda, Katsuhiro Masago, Fumihiro Tanaka, Megumi Hara, Nobuo Fuse, Satoshi S. Nishizuka, Noriko Motoi, Norie Sawada, Yuichiro Nishida, Kazuki Kumada, Kenji Takeuchi, Kozo Tanno, Yasushi Yatabe, Kuniko Sunami, Tomoyuki Hishida, Yasunari Miyazaki, Hidemi Ito, Mitsuhiro Amemiya, Hirohiko Totsuka, Haruhiko Nakayama, Tomoyuki Yokose, Kazuyoshi Ishigaki, Toshiteru Nagashima, Yoichi Ohtaki, Kazuhiro Imai, Ken Takasawa, Yoshihiro Minamiya, Kazuma Kobayashi, Kenichi Okubo, Kenji Wakai, Atsushi Shimizu, Masayuki Yamamoto, Motoki Iwasaki, Koichi Matsuda, Johji Inazawa, Yuichi Shiraishi, Hiroyoshi Nishikawa, Yoshinori Murakami, Michiaki Kubo, Fumihiko Matsuda, Yoichiro Kamatani, Ryuji Hamamoto, Keitaro Matsuo, Takashi Kohno

Publikováno v: Cancer Communications, Vol 44, Iss 2, Pp 287-293 (2024)

Externí odkaz: https://doaj.org/article/a4b8ea6db19942899046a4b6375483b8

Emerging PD-1/PD-L1 targeting immunotherapy in non-small cell lung cancer: Current status and future perspective in Japan, US, EU, and China

Autor: Takaaki Mizuno, Yuki Katsuya, Jun Sato, Takafumi Koyama, Toshio Shimizu, Noboru Yamamoto

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Non-small cell lung cancer (NSCLC), one of the deadliest types of cancers worldwide, has been the target of immunotherapy due to its high immune antigenicity. With the addition of immune-checkpoint inhibitors (ICIs), including anti-PD-1/PD-L1 antibod

Externí odkaz: https://doaj.org/article/9e9aa9d479eb41f89c2842574a3d8d16

Ocular toxicity of investigational anti-cancer drugs in early phase clinical trials

Autor: Shigemasa Takamizawa, Yuki Katsuya, Yi-Ning Chen, Takaaki Mizuno, Takafumi Koyama, Kazuki Sudo, Tatsuya Yoshida, Shunsuke Kondo, Satoru Iwasa, Kan Yonemori, Toshio Shimizu, Noboru Yamamoto, Shigenobu Suzuki

Publikováno v: Investigational New Drugs. 41:173-181

SummaryOcular toxicities arising from anti-cancer drugs occur sporadically and are sometimes underestimated because they are not life-threatening. Reports focusing on ocular toxicities from cancer therapy are limited. We investigated the detailed pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4b8f43c8345a02a53ec46487b8c298
https://doi.org/10.1007/s10637-022-01321-8