Zobrazeno 1 - 10
of 614
pro vyhledávání: '"Takaaki, Akaike"'
Autor:
Qi Cui, Meg Shieh, Tony W. Pan, Akiyuki Nishimura, Tetsuro Matsunaga, Shane S. Kelly, Shi Xu, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Xiaoyan Chen, Jerome R. Robinson, Wei-Jun Qian, Motohiro Nishida, Takaaki Akaike, Ming Xian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Reactive sulfane sulfur species such as persulfides (RSSH) and H2S2 are important redox regulators and closely linked to H2S signaling. However, the study of these species is still challenging due to their instability, high reactivity, and t
Externí odkaz:
https://doaj.org/article/72d2a7c0fb5042b78fe9869e15429d64
Autor:
Jun Suzuki, Tomotaka Hemmi, Tomoaki Ida, Seiryo Ogata, Jun Yoshitake, Tetsuro Matsunaga, Tomoyasu Ishida, Yuki Numano, Yusuke Kusano, Ryoukichi Ikeda, Kazuhiro Nomura, Mitsuru Sugawara, Nobuo Ohta, Takaaki Akaike, Yukio Katori
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 9, Iss 4, Pp n/a-n/a (2024)
Abstract Objectives Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body. Recently, supersulfides, in
Externí odkaz:
https://doaj.org/article/849c822bad834a4197b374d8fe72c6ce
Autor:
Tomas Majtan, Thomas Olsen, Jitka Sokolova, Jakub Krijt, Michaela Křížková, Tomoaki Ida, Tamás Ditrói, Hana Hansikova, Ondrej Vit, Jiri Petrak, Ladislav Kuchař, Warren D. Kruger, Péter Nagy, Takaaki Akaike, Viktor Kožich
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103222- (2024)
Background: Cystathionine β-synthase (CBS)-deficient homocystinuria (HCU) is an inherited disorder of sulfur amino acid metabolism with varying severity and organ complications, and a limited knowledge about underlying pathophysiological processes.
Externí odkaz:
https://doaj.org/article/b8708cd31b8443ea933830c25a0f91db
Autor:
Sho Kakizawa, Tomoko Arasaki, Ayano Yoshida, Ayami Sato, Yuka Takino, Akihito Ishigami, Takaaki Akaike, Shuichi Yanai, Shogo Endo
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103053- (2024)
Although reactive oxygen species (ROS) are known to have harmful effects in organisms, recent studies have demonstrated expression of ROS synthases at various parts of the organisms and the controlled ROS generation, suggesting possible involvement o
Externí odkaz:
https://doaj.org/article/620c3f16027140868431f1e0887cd72a
Autor:
Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Victor Tuan Giam Chuang, Ming Xian, Tatsuhiro Ishida, Takaaki Akaike, Yu Ishima
Publikováno v:
Advances in Redox Research, Vol 10, Iss , Pp 100091- (2024)
Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfi
Externí odkaz:
https://doaj.org/article/2b6c2c937d8747189a72409f65985d03
Autor:
Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine per
Externí odkaz:
https://doaj.org/article/1a6db92f44634602affb96764e95005a
Autor:
Hiroshi Tawarayama, Kota Umeki, Maki Inoue-Yanagimachi, Naoki Takahashi, Hirokazu Hasegawa, Noriko Himori, Satoru Tsuda, Hiroshi Kunikata, Takaaki Akaike, Toru Nakazawa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract We aimed to investigate the impact of glutathione trisulfide (GSSSG) on lipopolysaccharide (LPS)-induced inflammation in retinal glia. Inflammatory responses in mouse-derived glial cells and Wistar rat retinas were stimulated with administra
Externí odkaz:
https://doaj.org/article/05aac5d878cf48669ca0536413815423
Autor:
Akira Nishimura, Sunghyeon Yoon, Tetsuro Matsunaga, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Masanobu Morita, Jun Yoshitake, Yuka Unno, Uladzimir Barayeu, Tsuyoshi Takata, Hiroshi Takagi, Hozumi Motohashi, Albert van der Vliet, Takaaki Akaike
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103018- (2024)
Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supers
Externí odkaz:
https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df
Autor:
Shingo Kasamatsu, Takuma Owaki, Somei Komae, Ayaka Kinno, Tomoaki Ida, Takaaki Akaike, Hideshi Ihara
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102875- (2023)
Higher consumption of broccoli (Brassica oleracea var. italica) is associated with a reduced risk of cardiometabolic diseases, neurological disorders, diabetes, and cancer. Broccoli is rich in various phytochemicals, including glucosinolates, and iso
Externí odkaz:
https://doaj.org/article/44174cd3e7a14db9bd5f9079f6689077
Autor:
Touya Toyomoto, Katsuhiko Ono, Tomoo Shiba, Kenta Momitani, Tianli Zhang, Hiroyasu Tsutsuki, Takeshi Ishikawa, Kanae Hoso, Koma Hamada, Azizur Rahman, Liping Wen, Yosuke Maeda, Keiichi Yamamoto, Masao Matsuoka, Kenjiro Hanaoka, Takuro Niidome, Takaaki Akaike, Tomohiro Sawa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
A principal concept in developing antibacterial agents with selective toxicity is blocking metabolic pathways that are critical for bacterial growth but that mammalian cells lack. Serine O-acetyltransferase (CysE) is an enzyme in many bacteria that c
Externí odkaz:
https://doaj.org/article/244b49b9ab684654afb3f2435e33f014