Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Taka-Aki Ichu"'
Autor:
Alex Reed, Taka-Aki Ichu, Natalia Milosevich, Bruno Melillo, Michael A. Schafroth, Yuka Otsuka, Louis Scampavia, Timothy P. Spicer, Benjamin F. Cravatt
Publikováno v:
ACS chemical biology. 17(6)
LPCAT3 is an integral membrane acyltransferase in the Lands cycle responsible for generating C20:4 phospholipids and has been implicated in key biological processes such as intestinal lipid absorption, lipoprotein assembly, and ferroptosis. Small-mol
Autor:
Laura L. Kiessling, Radu M. Suciu, Madeline E. Kavanagh, Yongfeng Tao, Benjamin F. Cravatt, Michael R. Lazear, Taka-Aki Ichu, Matthew Merrill Hayward, Vincent M. Crowley, Mikail E. Abbasov, Melissa M. Dix, Jordan Ho, Stephan M. Hacker, Christopher W. am Ende
Publikováno v:
Nat Chem
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic electrophiles have been evaluated for interactions with the lysine proteome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f78bea59a5068219806c4dd51496f4d
https://europepmc.org/articles/PMC8952960/
https://europepmc.org/articles/PMC8952960/
Autor:
Benjamin F. Cravatt, Jonathan J. Hulce, Daisuke Ogasawara, Taka-Aki Ichu, Alex Reed, Olesya A. Ulanovskaya, Hui Jing
Publikováno v:
Journal of Medicinal Chemistry. 62:1643-1656
ABHD12 is a membrane-bound hydrolytic enzyme that acts on the lyso-phosphatidylserine (lyso-PS) and lyso-phosphatidylinositol (lyso-PI) classes of immunomodulatory lipids. Human and mouse genetic studies point to a key role for the ABHD12-(lyso)-PS/P
Autor:
Jacqueline R. Benthuysen, Vincent F. Vartabedian, Alex Reed, Hugh Rosen, Benjamin F. Cravatt, Amanda J. Roberts, Daisuke Ogasawara, Olesya A. Ulanovskaya, Hui Jing, Taka-Aki Ichu, Jonathan J. Hulce, John R. Teijaro, Steven D. Brown
Publikováno v:
Nature chemical biology
ABHD12 metabolizes bioactive lysophospholipids, including lysophosphatidylserine (lyso-PS). Deleterious mutations in human ABHD12 cause the neurological disease PHARC, and ABHD12(−/−) mice display PHARC-like phenotypes, including hearing loss, al
Autor:
Daisuke Ogasawara, Bruno Conti, Jason Germain, Kim Masuda, Liron Bar-Peled, Olesya A. Ulanovskaya, Amanda J. Roberts, Jie Gao, Taka-Aki Ichu, Sabrina Barbas, Benjamin F. Cravatt, Carlos A. Aguirre, Alex Reed, Peter Tontonoz
Publikováno v:
Biochemistry
PHARC (polyneuropathy, hearing loss, cerebellar ataxia, retinitis pigmentosa, and cataract) is a human neurological disorder caused by deleterious mutations in the ABHD12 gene, which encodes an integral membrane lyso-phosphatidylserine (lyso-PS) lipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c2d2fe86799d2b9d7c9bfcf98d189
https://europepmc.org/articles/PMC7394188/
https://europepmc.org/articles/PMC7394188/
Autor:
Mikail E. Abbasov, Radu M. Suciu, Yongfeng Tao, Stephan M. Hacker, Matthew Merrill Hayward, Laura L. Kiessling, Michael R. Lazear, Benjamin F. Cravatt, Taka-Aki Ichu, Christopher W. am Ende, Vincent M. Crowley, Madeline E. Kavanagh, Jordan Ho, Melissa M. Dix
Publikováno v:
Nature Chemistry. 13:1151-1151
Autor:
Kristen M. Turner, Jeremy N. Rich, Yuchao Gu, Ciro Zanca, Wenjing Zhang, Webster K. Cavenee, Taka-Aki Ichu, Oswald Quehenberger, Sudhir Chowdhry, Benjamin F. Cravatt, Frank B. Furnari, William H. Yong, Huijun Yang, Shiro Ikegami, Paul S. Mischel, Timothy F. Cloughesy, Genaro R. Villa, Sihan Wu, Wei Zhang, Alex Reed, Junfeng Bi, Harley I. Kornblum
Publikováno v:
Cell metabolism, vol 30, iss 3
Cell Metab
Cell Metab
Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors. Complementary biochemical and biophysical perspectives of cancer point towards profound shifts in nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b40afa8848326bcc0edde03e74952fb
https://escholarship.org/uc/item/6tv087c7
https://escholarship.org/uc/item/6tv087c7
Autor:
Gregg B. Morin, Sarah Vollett, Vicky C.-D. Chang, Marco A. Marra, S.-W. Grace Cheng, Annie Moradian, Malachi Griffith, Michael A. Kuzyk, Taka-Aki Ichu, Jerry F. Tien
Publikováno v:
Molecular and Cellular Biology. 32:4691-4704
CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing. While CDK12/CrkRS complexes were known to phosphorylate the C-terminal domain (CTD) of RN
Autor:
Catherine R. Propper, Pola Wojnarowicz, Linghong Lu, Caren C. Helbing, Mary Lesperance, Stacey K. Maher, Nik Veldhoen, Taka-Aki Ichu
Publikováno v:
Comparative biochemistry and physiology. Part D, Genomicsproteomics. 18
Thyroid hormones (THs), l-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), are essential for vertebrate growth and development. Classically, T4 is 5'-deiodinated to the active hormone, T3, in target tissues which then binds nuclear TH receptors (TRs)
Autor:
Hugh Rosen, Steven J. Brown, Bruno E. Correia, Kenneth M. Lum, Armand B. Cognetta, Taka-Aki Ichu, Fabiana Piscitelli, Jose Olucha, Soumajit Kundu, Benjamin F. Cravatt, Micah J. Niphakis
Publikováno v:
Cell (Cambridge) 161 (2015): 1668–1680. doi:10.1016/j.cell.2015.05.045
info:cnr-pdr/source/autori:Niphakis, Micah J.; Lum, Kenneth M.; Cognetta, Armand B., III; Correia, Bruno E.; Ichu, Taka-Aki; Olucha, Jose; Brown, Steven J.; Kundu, Soumajit; Piscitelli, Fabiana; Rosen, Hugh; Cravatt, Benjamin F./titolo:A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells/doi:10.1016%2Fj.cell.2015.05.045/rivista:Cell (Cambridge)/anno:2015/pagina_da:1668/pagina_a:1680/intervallo_pagine:1668–1680/volume:161
info:cnr-pdr/source/autori:Niphakis, Micah J.; Lum, Kenneth M.; Cognetta, Armand B., III; Correia, Bruno E.; Ichu, Taka-Aki; Olucha, Jose; Brown, Steven J.; Kundu, Soumajit; Piscitelli, Fabiana; Rosen, Hugh; Cravatt, Benjamin F./titolo:A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells/doi:10.1016%2Fj.cell.2015.05.045/rivista:Cell (Cambridge)/anno:2015/pagina_da:1668/pagina_a:1680/intervallo_pagine:1668–1680/volume:161
SummaryLipids play central roles in physiology and disease, where their structural, metabolic, and signaling functions often arise from interactions with proteins. Here, we describe a set of lipid-based chemical proteomic probes and their global inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7701d83be528fb04eb86cd74c103b066
https://europepmc.org/articles/PMC4615699/
https://europepmc.org/articles/PMC4615699/