Výsledky vyhledávání - "Tak Yung, Man"

Akademický článek

Combining human liver ECM with topographically featured electrospun scaffolds for engineering hepatic microenvironment

Autor: Yunxi Gao, Victoria L. Gadd, Maria Heim, Rhiannon Grant, Thomas S. R. Bate, Hannah Esser, Sofia Ferreira Gonzalez, Tak Yung Man, Stuart J. Forbes, Anthony Callanan

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)

Abstract Liver disease cases are rapidly expanding worldwide, and transplantation remains the only effective cure for end-stage disease. There is an increasing demand for developing potential drug treatments, and regenerative therapies using in-vitro

Externí odkaz: https://doaj.org/article/296f78107bb74eb78576ef134603feee

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Akademický článek

Utilising an in silico model to predict outcomes in senescence-driven acute liver injury

Autor: Candice Ashmore-Harris, Evangelia Antonopoulou, Rhona E. Aird, Tak Yung Man, Simon M. Finney, Annelijn M. Speel, Wei-Yu Lu, Stuart J. Forbes, Victoria L. Gadd, Sarah L. Waters

Publikováno v: npj Regenerative Medicine, Vol 9, Iss 1, Pp 1-17 (2024)

Abstract Currently liver transplantation is the only treatment option for liver disease, but organ availability cannot meet patient demand. Alternative regenerative therapies, including cell transplantation, aim to modulate the injured microenvironme

Externí odkaz: https://doaj.org/article/ae12cbb445934c8a8595557d05d68977

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Akademický článek

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Autor: Sofia Ferreira-Gonzalez, Wei-Yu Lu, Alexander Raven, Benjamin Dwyer, Tak Yung Man, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Tim J. Kendall, Thomas G. Bird, Nuria Tarrats, Juan-Carlos Acosta, Luke Boulter, Stuart J. Forbes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dep

Externí odkaz: https://doaj.org/article/fec37437098140028922b5a6d61c5040

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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

Publikováno v: Ferreira-Gonzalez, S, Man, T Y, Esser, H, Aird, R, Kilpatrick, A, Rodrigo Torres, D, Younger, N, Campana, L, Gadd, V, Dwyer, B, Aleksieva, N, Boulter, L, Macmillan, M, Wang, Y, Mylonas, K J, Ferenbach, D A, Kendall, T J, Lu, W-Y, Acosta, J C, Kurian, D, O'Neill, S, Oniscu, G, Banales, J M, Krimpenfort, P & Forbes, S J 2022, ' Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage ', Science Translational Medicine, vol. 14, no. 674, eabj4375 . https://doi.org/10.1126/scitranslmed.abj4375

Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue to occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d4735d36e8e39daf53ab681bc8df9
https://doi.org/10.1126/scitranslmed.abj4375

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Alternatively activated macrophages promote resolution of necrosis following acute liver injury

Autor: Alison C. MacKinnon, Lara Campana, Jennifer A Cartwright, Timothy J. Kendall, Rhona Aird, Lesley M. Forrester, Victoria L. Gadd, Adrian Thomson, Tak-Yung Man, Niya Aleksieva, Philip J. Starkey Lewis, Stuart J. Forbes, Eoghan O'Duibhir, Matthieu Vermeren, Adriano G. Rossi, Benjamin J. Dwyer, B. Kevin Park

Publikováno v: Journal of Hepatology

Background & Aim Following acetaminophen (APAP) overdose, acute liver injury (ALI) can occur in patients that present too late for N-acetylcysteine treatment, potentially leading to acute liver failure, systemic inflammation, and death. Macrophages i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a144fbb8faa74acc190f54184e3d618
https://doi.org/10.1016/j.jhep.2020.02.031

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Primary cilia in biliary regeneration-a potential approach to improve outcomes in liver transplantation

Autor: Hannah Esser, Sofia Ferreira-Gonzalez, Tak Yung Man, Alastair Kilpatrick, Daniel Rodrigo Torres, Rhona E. Aird, Candice Ashmore-Harris, Kayleigh Thirlwell, Benjamin J. Dwyer, Gabriel Oniscu, Stefan Schneeberger, Luke Boulter, Stuart Forbes

Publikováno v: Journal of Hepatology. 77:S85

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c1e5a48951fea8cde7863352fb24763
https://doi.org/10.1016/s0168-8278(22)00563-3

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Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

Publikováno v: Hallett, J, Ferreira-Gonzalez, S, Man, J, Kilpatrick, A, Esser, H, Thirwell, K, Macmillan, M, Rodrigo Torres, D, Dwyer, B, Gadd, V, Ashmore-Harris, C, Lu, W-Y, Thomson, J, Jansen, M, O'Duibhir, E, Starkey Lewis, P, Campana, L, Aird, R, Bate, T, Fraser, A R, Campbell, J D M, Oniscu, G C, Hay, D C, Callanan, A & Forbes, S J 2022, ' Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease ', Cell Stem Cell . https://doi.org/10.1016/j.stem.2022.02.006

Biliary diseases can cause inflammation, fibrosis, bile duct destruction, and eventually liver failure. There are no curative treatments for biliary disease except for liver transplantation. New therapies are urgently required. We have therefore puri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ac8dd45230457bbbf0f9ff444a375c
https://pubmed.ncbi.nlm.nih.gov/35245462

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TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression

Autor: Sofia Ferreira-Gonzalez, Eoghan O'Duibhir, Benjamin J. Dwyer, Timothy J. Kendall, Grant A. Ramm, Jully Gogoi-Tiwari, Stephen J. Wigmore, Lara Campana, Rachel V. Guest, Luke Boulter, Philip J. Starkey Lewis, Andrew Robson, Alastair M. Kilpatrick, Edward J. Jarman, Dominic Kurian, John K. Olynyk, Stuart J. Forbes, Tak Yung Man, Janina E.E. Tirnitz-Parker

Publikováno v: Dwyer, B J, Jarman, E J, Gogoi-Tiwari, J, Ferreira-Gonzalez, S, Boulter, L, Guest, R V, Kendall, T J, Thekkedath Kurian, D, Kilpatrick, A M, Robson, A J, O'Duibhir, E, Man, T Y, Campana, L, Starkey Lewis, P J, Wigmore, S J, Olynyk, J K, Ramm, G A, Tirnitz-Parker, J E E & Forbes, S J 2020, ' TWEAK/Fn14 signalling promotes cholangiocarcinoma niche formation and progression. ', Journal of Hepatology, vol. n/a, pp. 1-72 . https://doi.org/10.1016/j.jhep.2020.11.018

Background & Aims Cholangiocarcinoma (CCA) is a cancer of the hepatic bile ducts that is rarely resectable and is associated with poor prognosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) is known to signal via its receptor fibrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265247eb4c389f30f0be90e8acb35912
https://pubmed.ncbi.nlm.nih.gov/33583626

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11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation

Autor: Thorsten Forster, Manu Verma, Tak Yung Man, Megan C. Holmes, Zhenguang Zhang, Natalie Z.M. Homer, Tiina Kipari, Karen E. Chapman, Jonathan R. Seckl

Publikováno v: Verma, M, Kipari, T, Zhang, Z, Man, T Y, Forster, T, Homer, N Z M, Seckl, J R, Holmes, M C & Chapman, K E 2017, ' 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation ', Brain, Behavior, and Immunity . https://doi.org/10.1016/j.bbi.2017.11.015
Brain, Behavior, and Immunity

Highlights • 11β-HSD1-deficiency reduces the hippocampal inflammatory response to LPS. • This happens despite similar peripheral inflammation. • 11β-HSD1-deficiency favours a “Warburg” like response to LPS in the hippocampus. • LPS incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcbfbdd2ee3a67bd429f3d5fdeb6e02
https://hdl.handle.net/20.500.11820/87e3bca5-01b4-4b24-9959-af9148236678

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