Zobrazeno 1 - 10
of 1 626
pro vyhledávání: '"Tak W. Mak"'
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Carcinogen exposure has been associated with enhanced cancer immunogenicity that is often attributed to neoantigen generation. However, the broader, neoantigen-independent impact of carcinogens on immune responses to cancer cells remains underexplore
Externí odkaz:
https://doaj.org/article/fdbfee81881e4774ad1a532c92d24563
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/28235f9d15cb48229d586a6af57f11de
Autor:
Takahiko Akagi, Sumie Hiramatsu-Asano, Kenta Ikeda, Hiroyasu Hirano, Shoko Tsuji, Ayano Yahagi, Masanori Iseki, Makoto Matsuyama, Tak W. Mak, Kazuhisa Nakano, Katsuhiko Ishihara, Yoshitaka Morita, Tomoyuki Mukai
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory periodic fever syndrome associated with heterozygous mutations in TNFRSF1A, which encodes TNF receptor type I (TNFR1). Although possible proinflammatory
Externí odkaz:
https://doaj.org/article/3a1779affaa84f05b7ea4fdafba51136
Autor:
Tharini Sivasubramaniyam, Jiaqi Yang, Henry S. Cheng, Alexandra Zyla, Angela Li, Rickvinder Besla, Idit Dotan, Xavier S. Revelo, Sally Yu Shi, Helen Le, Stephanie A. Schroer, David W. Dodington, Yoo Jin Park, Min Jeong Kim, Daniella Febbraro, Isabelle Ruel, Jacques Genest, Raymond H. Kim, Tak W. Mak, Daniel A. Winer, Clinton S. Robbins, Minna Woo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect against
Externí odkaz:
https://doaj.org/article/dd1b0c94e3934c83829b8e94c00d30fc
Autor:
Yogesh Singh, Christoph Trautwein, Achal Dhariwal, Madhuri S. Salker, Md Alauddin, Laimdota Zizmare, Lisann Pelzl, Martina Feger, Jakob Admard, Nicolas Casadei, Michael Föller, Vivek Pachauri, David S. Park, Tak W. Mak, Julia-Stefanie Frick, Diethelm Wallwiener, Sara Y. Brucker, Florian Lang, Olaf Riess
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract The proper communication between gut and brain is pivotal for the maintenance of health and, dysregulation of the gut-brain axis can lead to several clinical disorders. In Parkinson’s disease (PD) 85% of all patients experienced constipati
Externí odkaz:
https://doaj.org/article/297b1457494e463d9c3a718090284705
Autor:
Min Jeong Kim, Daniella Febbraro, Sofia Farkona, Taylor Gillmore, Joe Eun Son, Romario Regeenes, Huntley H. Chang, Evan Pollock-Tahiri, Jiaqi Yang, Yoo Jin Park, Tharini Sivasubramaniyam, Soo Jung Oh, Punit Saraon, Igor Stagljar, Jonathan V. Rocheleau, Chi-Chung Hui, Isabella Caniggia, Zhenyu Hao, Tak W. Mak, Ana Konvalinka, Minna Woo
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101185- (2021)
Objective: Autophagy is a physiological self-eating process that can promote cell survival or activate cell death in eukaryotic cells. In skeletal muscle, it is important for maintaining muscle mass and function that is critical to sustain mobility a
Externí odkaz:
https://doaj.org/article/3ad65f38e4f146d3afd318e6c0762d84
Autor:
Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti
Externí odkaz:
https://doaj.org/article/249fbfe56ab6438d997eb47907be7294
Publikováno v:
Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-14 (2019)
Abstract Background Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory responses. To study the me
Externí odkaz:
https://doaj.org/article/b27b150d37914016bd91b1135fcb3ebf
Autor:
Nikita Patel, Juehong Wang, Kumiko Shiozawa, Kevin B. Jones, Yanfeng Zhang, Jeremy W. Prokop, George G. Davenport, Naoe T. Nihira, Zhenyue Hao, Derek Wong, Laurel Brandsmeier, Sarah K. Meadows, Arthur V. Sampaio, Ryan Vander Werff, Makoto Endo, Mario R. Capecchi, Kelly M. McNagny, Tak W. Mak, Torsten O. Nielsen, T. Michael Underhill, Richard M. Myers, Tadashi Kondo, Le Su
Publikováno v:
iScience, Vol 13, Iss , Pp 43-54 (2019)
Summary: Histone deacetylases (HDACs) are promising targets for cancer therapy, although their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in the regulation of MDM2 acetylation at previously uncharacterized l
Externí odkaz:
https://doaj.org/article/86168b789a6f460780d4cbfa71bccd3c
Autor:
Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang, Peng Jiang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed ste
Externí odkaz:
https://doaj.org/article/40ebfb1c694843deb3649bc0de6df26d