Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Tak S Cheng"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125696 (2015)
Disulfiram (DSF), a cysteine modifying compound, has long been clinically employed for the treatment of alcohol addiction. Mechanistically, DSF acts as a modulator of MAPK and NF-κB pathways signaling pathways. While these pathways are crucial for o
Externí odkaz:
https://doaj.org/article/0020eaf6b8df4e2c835b95b423e3c710
Autor:
An Qin, Tak S Cheng, Zhen Lin, Lei Cao, Shek M Chim, Nathan J Pavlos, Jiake Xu, Ming Hao Zheng, Ke Rong Dai
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34132 (2012)
Wear particle-induced peri-implant loosening (Aseptic prosthetic loosening) is one of the most common causes of total joint arthroplasty. It is well established that extensive bone destruction (osteolysis) by osteoclasts is responsible for wear parti
Externí odkaz:
https://doaj.org/article/0a06ac5486d24b359f5181218ac024c6
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27155 (2011)
Vacuolar-type H(+)-ATPases (V-ATPases) are macromolecular proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of a variety of specialized cells, including bone-resorbing osteoclasts. Extracellular acidificati
Externí odkaz:
https://doaj.org/article/4fc5ed48e81d4d05a1e72eb3d2e29293
Autor:
Xiang, Zhu, Junjie, Gao, Pei Y, Ng, An, Qin, James H, Steer, Nathan J, Pavlos, Ming H, Zheng, Yang, Dong, Tak S, Cheng
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31(3)
Aseptic loosening and periprosthetic infection leading to inflammatory osteolysis is a major complication associated with total joint arthroplasty (TJA). The liberation of bacterial products and/or implant-derived wear particles activates immune cell