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Akademický článek

Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication

Autor: Yasir Mohamud, Junyan Shi, Junyan Qu, Tak Poon, Yuan Chao Xue, Haoyu Deng, Jingchun Zhang, Honglin Luo

Publikováno v: Cell Reports, Vol 22, Iss 12, Pp 3292-3303 (2018)

Summary: Picornaviruses have evolved to hijack host cellular machinery, including the autophagic pathway. However, the mechanisms remain largely unclear. We use coxsackievirus B3 (CVB3) as a model organism to explore the possible role of picornavirus

Externí odkaz: https://doaj.org/article/651984ea4eed4d1f828ef92f2cc54733

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Akademický článek

Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets

Autor: John J. Shin, Qurratulain Aftab, Pamela Austin, Jennifer A. McQueen, Tak Poon, Shu Chen Li, Barry P. Young, Calvin D. Roskelley, Christopher J. R. Loewen

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1039-1049 (2016)

A hallmark of all primary and metastatic tumours is their high rate of glucose uptake and glycolysis. A consequence of the glycolytic phenotype is the accumulation of metabolic acid; hence, tumour cells experience considerable intracellular acid stre

Externí odkaz: https://doaj.org/article/e4ad6a9d9de942b1a8efd2584d4da9bd

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Akademický článek

Development of an individualized risk calculator of treatment resistance in patients with first-episode psychosis (TRipCal) using automated machine learning: a 12-year follow-up study with clozapine prescription as a proxy indicator

Autor: Ting Yat Wong, Hao Luo, Jennifer Tang, Tyler M. Moore, Ruben C. Gur, Yi Nam Suen, Christy Lai Ming Hui, Edwin Ho Ming Lee, Wing Chung Chang, Wai Ching Yan, Eileena Chui, Lap Tak Poon, Alison Lo, Koi-Man Cheung, Chui Kwan Kan, Eric Yu Hai Chen, Sherry Kit Wa Chan

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract About 15–40% of patients with schizophrenia are treatment resistance (TR) and require clozapine. Identifying individuals who have higher risk of development of TR early in the course of illness is important to provide personalized interven

Externí odkaz: https://doaj.org/article/d8a593c72d9747b6b690e44cb60e3f47

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Akademický článek

Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up studyResearch in context

Autor: Wing Tse, Golam M. Khandaker, Huiquan Zhou, Hao Luo, Wai Ching Yan, Man Wah Siu, Lap Tak Poon, Edwin Ho Ming Lee, Qingpeng Zhang, Rachel Upthegrove, Emanuele F. Osimo, Benjamin I. Perry, Sherry Kit Wa Chan

Publikováno v: The Lancet Regional Health. Western Pacific, Vol 47, Iss , Pp 101089- (2024)

Summary: Background: Metabolic syndrome (MetS) is common following first-episode psychosis (FEP), contributing to substantial morbidity and mortality. The Psychosis Metabolic Risk Calculator (PsyMetRiC), a risk prediction algorithm for MetS following

Externí odkaz: https://doaj.org/article/1eceb9313fdf453ab4018f6244637f98

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Akademický článek

Objectification decreases prosociality: the mediating role of relative deprivation

Autor: Zaixuan Zhang, Zhansheng Chen, Kai-Tak Poon, Tonglin Jiang

Publikováno v: Frontiers in Psychology, Vol 14 (2023)

Objectification denies individuals’ personhood and renders them as tools for facilitating others’ goal achievement. With two studies (N = 446), the present investigation aimed to contribute to the literature by testing whether and how objectifica

Externí odkaz: https://doaj.org/article/079b2763b4ff4e7bbf2e7011a19e6f69

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