Vagus nerve stimulation in patients with rheumatoid arthritis: 48 month safety and efficacy

Autor: Koopman, F, Musters, A, Backer, M, Gerlag, D, Miljko, S, Grazio, Simeon, Sokolović, Š, Levine, Y, Glass, E Chernoff D, De Vries N, Tak PP

Background: Rheumatoid arthritis (RA) is a disease with significant remaining unmet medical needs for better treatments. Vagus nerve stimulation (VNS) to activate the inflammatory reflex (cholinergic anti-inflammatory pathway) repre sents a novel exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::048bf084fbc5154330370b829c195cc1
https://doi.org/0.1136/annrheumdis-2020-eular.2914

Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients

Autor: Taylor, JC, Bongartz, T, Massey, J, Mifsud, B, Spiliopoulou, A, Scott, IC, Wang, J, Morgan, M, Plant, D, Colombo, M, Orchard, P, Twigg, S, McInnes, IB, Porter, D, Freeston, JE, Nam, JL, Cordell, HJ, Isaacs, JD, Strathdee, JL, Arnett, D, de Hair, MJH, Tak, PP, Aslibekyan, S, van Vollenhoven, RS, Padyukov, L, Bridges, SL, Pitzalis, C, Cope, AP, Verstappen, SMM, Emery, P, Barnes, MR, Agakov, F, McKeigue, P, Mushiroda, T, Kubo, M, Weinshilboum, R, Barton, A, Morgan, AW, Barrett, JH, on behalf of the MATURA and PAMERA consortia

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::60e9c2fb6ff8fbbbe6d6a2ccc1ff8622

Vagus nerve stimulation in patients with rheumatoid arthritis: 24 month safety an efficacy

Autor: Koopman FA, Musters A, Backer MMJ, Gerlag D, Miljko S, Grazio S, Sokolović Š, Levine Y, Chernoff D, de Vries N, Tak PP.

Background/Purpose: RA is a debilitating chronic disease with an unmet need for additional therapeutic approaches. Modulating innate neuro-immune re ex pathways by stimulation of the vagus nerve (VNS) could represent a novel means of treating RA (van

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::ddcb0abc27ec0386a45a6e6cf62d2415
https://www.bib.irb.hr/985821

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial

Autor: Tak, Pp, Rigby, Wf, Rubbert Roth, A, Peterfy, Cg, van Vollenhoven RF, Stohl, W, Hessey, E, Chen, A, Tyrrell, H, Shaw, Tm, Aelion J, IMAGE I. n. v. e. s. t. i. g. a. t. o. r. s., Afif, N, Ahmadi, F, Aires, F, Alanis, E, Alonso, Cs, Alten, Rh, Alvaro Gracia JM, Ashrafzadeh, A, Ballina, J, Bambara, Lm, Bao, C, Bell, M, Berney, S, Bessette, L, Birbara, C, Boling, E, Bourgeois, P, Braun, J, Briones, H, Brzezicki, J, Burgos Vargos, R, Burmester, G, Burnett, M, Busch, H, Cabello, E, Calvo, A, Cantagrel, A, Cantini, F, Zea, Ac, Carreño Perez, L, Chavez, J, Shim, Sc, Chindalore, V, Chiriac, R, Codding, C, Danda, D, Del Guidice, J, De Vita, S, Digiovanni, R, Dikranian, A, Eider, W, Fantini, F, Ferraccioli, G, Fietchner, J, Filipowicz Sosnowska, A, Finnanger, B, Fiocco, G, Fleck, M, Fleischmann, R, Fraser, A, Gaudin, P, Gauler, G, Gaylis, N, Gerlag, Dm, Godde, J, Gomez Reino JJ, Gornisiewicz, M, Gough, W, Greenwald, M, Guerra, G, Hackshaw, K, Haentzschel, Hm, Hammond, T, Hazleman, Bl, Heilig, B, Herenius, Mm, Hilliquin, P, Holt, D, Huang, F, Huff, J, Huizinga, T, Isaacs, J, Jaffer, A, Amante, Ej, Jeka, S, Jimenez, R, Jones, G, Jones, R, Kaine, J, Kashif, A, Kaufmann, C, Kay, J, Khraishi, M, Kivitz, A, Klinkhoff, A, Kraag, G, Krystufkova, O, Kucharz, E, Lawson, J, Leirisalo Repo, M, Levin, R, Liang, G, Liang, P, Limonta, M, Lowenstein, M, Rodriguez Lozano, C, Lue, C, Mahowald, M, Maradiaga, M, Maricic, M, Mariette, X, Martin, L, Massarotti, E, Matucci Cerinic, M, Montecucco, Cm, Mazurov, V, Mcnally, J, Mehta, D, Meyer, O, Misra, R, Moreland, Lw, Mueller Ladner, U, Myerson, G, Nasonov, E, Navarra, S, Navarro, F, Neal, N, Olech, E, Olsen, N, Pablos, Jl, Pacheco, C, Pal, S, Palomo, Er, Pandith, V, Penserga, Eg, Prupas, H, Radominski, S, Ramos Remus, C, Reid, D, Riordan, K, Rosenberg, D, Ruiz, A, Saadeh, C, Salvarani, Carlo, Samuels, A, Sanmarti, R, Sarzi Puttini, P, Saxe, P, Schechtman, J, Scoville, C, Sedlackova, M, Sedrish, M, Sejer Hansen, M, Sibilia, J, Siebert, S, Specker, C, Stern, S, Szechinski, J, Tahir, H, Taylor, A, Thompson, Pw, Tony, Hp, Tornero, J, Trapp, R, Tremblay, Jl, Valesini, G, Van Den Bosch, F, Wanchu, A, Wassenberg, S, Ximenes, Ac, Kim, Hy, Zanetakis, E, Zazueta, B, Zerbini, C.

Publikováno v: Annals of the Rheumatic Diseases, 70(1), 39-46. BMJ Publishing Group
Annals of the rheumatic diseases, 70(1), 39-46. BMJ Publishing Group

Objectives: Rituximab is an effective treatment in patients with established rheumatoid arthritis (RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the prevention of joint damage and its safety in combination with m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80a94d92fa815c8602c1c10bf00fd4d
https://doi.org/10.1136/ard.2010.137703

Efficacy and safety of various repeat treatment dosing regimens of rituximab in patients with active rheumatoid arthritis: results of a Phase III randomized study (MIRROR)

Autor: RUBBERT ROTH, A, Tak, Pp, Zerbini, C, Tremblay, Jl, Carreño, L, Armstrong, G, Collinson, N, Shaw, Tm, Bombardieri, Stefano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3728::f419f1f5fc05c679dfda5bf70aef9a60
http://hdl.handle.net/11568/142550