Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tajib Mirzabekov"'
Autor:
Sergei E. Permyakov, Tajib Mirzabekov, Andrei S. Sokolov, Roman Mikhailov, Andrey R. Yakovenko, Alexei S. Kazakov, Ramis G. Ismailov, Eugene A. Permyakov, Ulitin Andrei Borisovich, Solovyev Valery Vladimirovich, Victoria A. Rastrygina
Publikováno v:
Biochemical and Biophysical Research Communications. 468:733-738
Interleukin-11 (IL-11) and S100P are oncoproteins co-expressed in numerous cancers, which might favor their interaction during oncogenesis. We have explored the possibility of this interaction by surface plasmon resonance spectroscopy, intrinsic fluo
Autor:
Alexei S. Kazakov, Anna V. Lomonosova, Ulitin Andrei Borisovich, Tajib Mirzabekov, Sergei E. Permyakov, Eugene A. Permyakov
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170349 (2017)
PLoS ONE, Vol 12, Iss 1, p e0170349 (2017)
Small antibody mimetics, or alternative binding proteins (ABPs), extend and complement antibody functionality with numerous applications in research, diagnostics and therapeutics. Given the superiority of ABPs, the last two decades have witnessed dev
Autor:
Evgeni Yu. Zernii, Maria E. Permyakova, Victoria A. Rastrygina, Ramis G. Ismailov, Alisa A. Vologzhannikova, Vladimir N. Uversky, Konstantin Denessiouk, Viktoriia E. Baksheeva, Alexander I. Denesyuk, Alexei S. Kazakov, Andrei S. Sokolov, Tajib Mirzabekov, Vladimir V. Glazatov, Eugene A. Permyakov, Sergei E. Permyakov, Polina Khorn, Dmitry V. Zinchenko
Publikováno v:
Journal of biomolecular structuredynamics. 35(1)
Interleukin-11 (IL-11) is a hematopoietic cytokine engaged in numerous biological processes and validated as a target for treatment of various cancers. IL-11 contains intrinsically disordered regions that might recognize multiple targets. Recently we
Autor:
Anna V. Lomonosova, E. V. Ovchinnikova, Roman Mikhailov, Alexei S. Kazakov, Tajib Mirzabekov, Ulitin Andrei Borisovich, Eugene A. Permyakov, A. D. Sofin, Alexander I. Denesyuk, Sergei E. Permyakov
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0134906 (2015)
PLoS ONE, Vol 10, Iss 8, p e0134906 (2015)
Due to their remarkably high structural stability, proteins from extremophiles are particularly useful in numerous biological applications. Their utility as alternative protein scaffolds could be especially valuable in small antibody mimetic engineer
Autor:
Joseph Sodroski, Michael Farzan, Kara Carter, John L. Joyal, Tajib Mirzabekov, Woj M. Wojtowicz, David I. Israel, Gregory J. Babcock
Publikováno v:
Journal of Biological Chemistry. 277:35019-35024
Alzheimer's disease is characterized by deposition of beta-amyloid peptide (Abeta) into plaques in the brain, leading to neuronal toxicity and dementia. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system can also caus
Publikováno v:
Journal of Biological Chemistry. 276:38433-38440
The G protein-coupled receptor CXCR4 is a coreceptor, along with CD4, for the human immunodeficiency virus type 1 (HIV-1) and has been implicated in breast cancer metastasis. We studied the binding of the HIV-1 gp120 envelope glycoprotein (gp) to CXC
Enhanced Expression, Native Purification, and Characterization of CCR5, a Principal HIV-1 Coreceptor
Autor:
Tajib Mirzabekov, Peter Kolchinsky, Michael Farzan, Richard T. Wyatt, Wolfgang Hofmann, Norbert Bannert, Lijun Wu, Joseph Sodroski
Publikováno v:
Journal of Biological Chemistry. 274:28745-28750
Seven-transmembrane segment, G protein-coupled receptors (GPCRs) play important roles in many biological processes in which pharmaceutical intervention may be useful. High level expression and native purification of GPCRs are important steps in the b
Autor:
Hyeryun Choe, Joseph Sodroski, Tajib Mirzabekov, Mark Cayabyab, Michael Farzan, Peter Kolchinsky, Enko Kiprilov, Larissa J. Mooney
Publikováno v:
Scopus-Elsevier
The gp120 envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1) promotes virus entry by sequentially binding CD4 and chemokine receptors on the target cell. Primary, clinical HIV-1 isolates require interaction with CD4 to allow gp1
Publikováno v:
Seibutsu Butsuri. 38:217-222
Autor:
Ellen S. Shang, David R. Blanco, Jonathan T. Skare, Bruce E. Kagan, M A Lovett, James N. Miller, Sven Bergström, Paul Tempst, Tajib Mirzabekov, Hediye Erdjument-Bromage, Jonas Bunikis
Publikováno v:
Infection and Immunity. 65:3654-3661
In this study we report the purification and characterization of a 66-kDa protein, designated Oms66, for outer membrane-spanning 66-kDa protein, that functions as a porin in the outer membrane (OM) of Borrelia burgdorferi. Oms66 was purified by fast-