Výsledky vyhledávání - "Tajib A Mirzabekov"

Akademický článek

Derivative of Extremophilic 50S Ribosomal Protein L35Ae as an Alternative Protein Scaffold.

Autor: Anna V Lomonosova, Andrei B Ulitin, Alexei S Kazakov, Tajib A Mirzabekov, Eugene A Permyakov, Sergei E Permyakov

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170349 (2017)

Small antibody mimetics, or alternative binding proteins (ABPs), extend and complement antibody functionality with numerous applications in research, diagnostics and therapeutics. Given the superiority of ABPs, the last two decades have witnessed dev

Externí odkaz: https://doaj.org/article/b2cb9c993d7741e0838077d0271c1463

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Akademický článek

Extremophilic 50S Ribosomal RNA-Binding Protein L35Ae as a Basis for Engineering of an Alternative Protein Scaffold.

Autor: Anna V Lomonosova, Elena V Ovchinnikova, Alexei S Kazakov, Alexander I Denesyuk, Alexander D Sofin, Roman V Mikhailov, Andrei B Ulitin, Tajib A Mirzabekov, Eugene A Permyakov, Sergei E Permyakov

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134906 (2015)

Due to their remarkably high structural stability, proteins from extremophiles are particularly useful in numerous biological applications. Their utility as alternative protein scaffolds could be especially valuable in small antibody mimetic engineer

Externí odkaz: https://doaj.org/article/69dc8a9ab4a84808b4790602bfa4e9e2

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A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Publikováno v: Clinical Cancer Research. :OF1-OF16

Purpose: Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments produce impressive initial responses, eventual resistance onset is practically unavoida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9093b523847f1e2653795293982fb01d
https://doi.org/10.1158/1078-0432.ccr-22-2535

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Figure S1 from A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Fig. S1. The amino acid sequence of EPHA2 extracellular portion composed of ligand bindingdomain followed by sushi-like domain and two sequential fibronectin-like domains is highlyconserved among mammals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a59b764f3c21b1ae1bdb483d0ebc7db
https://doi.org/10.1158/1078-0432.22348792

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Supplementary Table S6 from A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Table S6: Hits from the EPHA2 BioID assay.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9afd54ebc1b43dea456245b4b9842f
https://doi.org/10.1158/1078-0432.22348756

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Supplementary Materials and Methods1 from A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Supplementary Materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a055f77c4a541102cd185baab2d0e2e
https://doi.org/10.1158/1078-0432.22348774.v1

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Data from A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Purpose:Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments produce impressive initial responses, eventual resistance onset is practically unavoidab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77399568089020e054e24e0831df64c9
https://doi.org/10.1158/1078-0432.c.6489326.v1

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Redistribution of the electric field within the pore contributes to the voltage-dependence of mitochondrial porin channel

Autor: Tajib A. Mirzabekov, L.N. Ermishkin

Publikováno v: Biochimica et biophysica acta. 1021(2)

The effects of pH on the integral conductance and on the properties of single channels induced by porin from rat liver mitochondria in a lipid bilayer have been studied. When the membrane potential increases, the conductance of the multi-channel memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d42bedfe5b21b41366a34c767c3f551f
https://pubmed.ncbi.nlm.nih.gov/1689178

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The gate of mitochondrial porin channel is controlled by a number of negative and positive charges

Autor: L.N. Ermishkin, Tajib A. Mirzabekov

Publikováno v: FEBS letters. 249(2)

Negatively charged carboxyl groups of mitochondrial porin have been converted into positively charged ones by means of reaction with water-soluble carbodiimide in the presence of ethylenediamine. Properties of channels formed in a planar lipid bilaye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac3f91af1b8615bf612a5b7901b7ef6
https://pubmed.ncbi.nlm.nih.gov/2472293

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