Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Taixiang Saur"'
Autor:
XIN WANG, Limin Hao, Taixiang Saur, Katelyn JOYAL, Ying Zhao, Desheng Zhai, Jie Li, Mochtar Pribadi, Giovanni Coppola, Bruce M Cohen, Edgar(Ned) A Buttner
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD). Both gain-of-function (gf) and loss-of-function (lf) mechanisms have be
Externí odkaz:
https://doaj.org/article/3e8f410271b548a090223a6ddf7f7562
Autor:
Taixiang Saur, Sarah E DeMarco, Angelica Ortiz, Gregory R Sliwoski, Limin Hao, Xin Wang, Bruce M Cohen, Edgar A Buttner
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003313 (2013)
We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen identi
Externí odkaz:
https://doaj.org/article/50de190b421c4e0fbd75db1a96880fda
Publikováno v:
Journal of Neurogenetics. 30:259-275
Intrinsic electric activities of neurons play important roles in establishing and refining neural circuits during development. However, how the underlying ionic currents undergo postembryonic reorganizations remains largely unknown. Using acutely dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb321a408ecb77d210dbed50c792b1c3
https://doi.org/10.1080/01677063.2016.1255212
https://doi.org/10.1080/01677063.2016.1255212
Publikováno v:
Journal of Neurogenetics. 30:297-305
Cholinergic dysfunction contributes to cognitive deficits associated with various neuropsychiatric disorders, including schizophrenia. The atypical antipsychotic clozapine improves cognitive function in patients with schizophrenia, possibly through m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8002fd8f295009037682a35303a6c6
https://doi.org/10.1080/01677063.2016.1229779
https://doi.org/10.1080/01677063.2016.1229779
Publikováno v:
Frontiers in Neural Circuits
Frontiers in Neural Circuits, Vol 8 (2014)
Frontiers in Neural Circuits, Vol 8 (2014)
Spike timing-dependent plasticity (STDP) of glutamatergic synapses is a Hebbian associative plasticity that may underlie certain forms of learning. A cardinal feature of STDP is its dependence on the temporal order of presynaptic and postsynaptic spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d6aa60b7cd2f756df57d94bd0684ab
https://doi.org/10.3389/fncir.2014.00038
https://doi.org/10.3389/fncir.2014.00038
Autor:
James K. Rowlett, Angela N. Duke, Seth G. N. Grant, Wei-Dong Yao, Ole Isacson, Jingping Zhang, Taixiang Saur, Donna M. Platt
Publikováno v:
Journal of neurogenetics. 28(1-2)
Excessive activation of the N-methyl-d-aspartate (NMDA) receptor and the neurotransmitter dopamine (DA) mediate neurotoxicity and neurodegeneration under many neurological conditions, including Huntington's disease (HD), an autosomal dominant neurode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29da282e6e7001ed15615c72335dae
https://pubmed.ncbi.nlm.nih.gov/24702501
https://pubmed.ncbi.nlm.nih.gov/24702501
Autor:
Angelica Ortiz, Sarah E. DeMarco, Xin Wang, Gregory Sliwoski, Bruce M. Cohen, Taixiang Saur, Edgar A. Buttner, Limin Hao
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 9, Iss 2, p e1003313 (2013)
PLoS Genetics, Vol 9, Iss 2, p e1003313 (2013)
We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543b67f9170d44af164ed34fc246d2ab
https://pubmed.ncbi.nlm.nih.gov/23468647
https://pubmed.ncbi.nlm.nih.gov/23468647
Publikováno v:
Frontiers in Neural Circuits; Apr2014, Vol. 8, preceding p1-30, 38p