Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Taisuke Kanaji"'
Autor:
Taisuke Kanaji, Xiang-Lei Yang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102297- (2024)
Externí odkaz:
https://doaj.org/article/0abf47a10c4f42e9b8c5dcd24377aff8
Autor:
Julia A. Jones, Na Wei, Haissi Cui, Yi Shi, Guangsen Fu, Navin Rauniyar, Ryan Shapiro, Yosuke Morodomi, Nadine Berenst, Calin Dan Dumitru, Sachiko Kanaji, John R. Yates, III, Taisuke Kanaji, Xiang-Lei Yang
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112632- (2023)
Summary: Various stress conditions are signaled through phosphorylation of translation initiation factor eukaryotic initiation factor 2α (eIF2α) to inhibit global translation while selectively activating transcription factor ATF4 to aid cell surviv
Externí odkaz:
https://doaj.org/article/a0eab927d61c4462b44a1c35a518cd79
Autor:
Eric Won, Yosuke Morodomi, Sachiko Kanaji, Ryan Shapiro, My‐Nuong Vo, Jennifer N. Orje, Courtney D. Thornburg, Xiang‐Lei Yang, Zaverio M. Ruggeri, Paul Schimmel, Taisuke Kanaji
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1167-1177 (2020)
Abstract Background Tyrosyl‐tRNA synthetase (YRS) belongs to the family of enzymes that catalyzes the tRNA aminoacylation reaction for protein synthesis, and it has been recently shown to exert noncanonical functions. Although database results indi
Externí odkaz:
https://doaj.org/article/e4c71f223dd0404b8b8a219a41077875
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 1, Pp 86-91 (2020)
Abstract Background Super‐resolution microscopy has enabled high‐resolution imaging of the actin cytoskeleton in megakaryocytes and platelets. These technologies have extended our knowledge of thrombopoiesis and platelet spreading using megakaryo
Externí odkaz:
https://doaj.org/article/b5f2a403af0e4fb584989a4e94159f95
Autor:
Sachiko Kanaji, Yosuke Morodomi, Hartmut Weiler, Alessandro Zarpellon, Robert R. Montgomery, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Type 2B von Willebrand disease (VWD) is caused by gain-of-function mutations in von Willebrand factor (VWF). Increased VWF affinity for GPIba results in loss of high molecular weight multimers and enhanced platelet clearance, both contributing to the
Externí odkaz:
https://doaj.org/article/5292c9accfd547d095570b33387baee9
Publikováno v:
Thrombosis Research. 220:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0d4232a1a1aae9c25c587c5b70f6c7
https://doi.org/10.1016/j.thromres.2022.10.003
https://doi.org/10.1016/j.thromres.2022.10.003
Autor:
Yosuke Morodomi, Sachiko Kanaji, Brian M. Sullivan, Alessandro Zarpellon, Jennifer N. Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
Platelets play a role not only in hemostasis and thrombosis, but also in inflammation and innate immunity. We previously reported that an activated form of tyrosyl-tRNA synthetase (YRS ACT ) has an extratranslational activity that enhances megakaryop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c5d3c3d4822deaeac39b6b7e1f0b6a
https://pubmed.ncbi.nlm.nih.gov/36409883
https://pubmed.ncbi.nlm.nih.gov/36409883
Publikováno v:
Trends in biochemical sciences.
Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by circulating autoantibodies against one of eight aminoacyl-tRNA synthetases (aaRSs). Although these autoantibodies are believed to play critical roles in ASSD pathogenesis, the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffbe179f143b48a8b2788332d329177
https://pubmed.ncbi.nlm.nih.gov/36280495
https://pubmed.ncbi.nlm.nih.gov/36280495
Publikováno v:
Blood
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by antibody-mediated platelet destruction. Different mechanisms have been suggested to explain accelerated platelet clearance and impaired thrombopoiesis, but the pathophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372b88948b7340e15c349ed2d16e55a4
https://doi.org/10.1182/blood.2019003770
https://doi.org/10.1182/blood.2019003770
Autor:
Taisuke Kanaji
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 31:485-490
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a1ac601a626041cf00d5988aa8492e
https://doi.org/10.2491/jjsth.31.485
https://doi.org/10.2491/jjsth.31.485