Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Taishi Higashi"'
Autor:
Aiko Sakai, Yuki Yamashita, Shogo Misumi, Naoki Kishimoto, Risako Onodera, Taishi Higashi, Hidetoshi Arima, Keiichi Motoyama
Publikováno v:
FEBS Open Bio, Vol 13, Iss 2, Pp 233-245 (2023)
Supramolecular drug carriers are a promising approach for delivering anticancer drugs with high blood retention after administration. We previously synthesized folic acid‐modified methyl‐β‐cyclodextrin (FA‐MβCD) as an anticancer drug. FA‐
Externí odkaz:
https://doaj.org/article/8d71275a5ef54afb9f834ac620d8ab3a
Autor:
Yuika Goto, Airi Obata, Masamichi Inoue, Toru Taharabaru, Takuya Kihara, Risako Onodera, Daisuke Iohara, Makoto Takafuji, Keiichi Motoyama, Taishi Higashi
Publikováno v:
Results in Materials, Vol 19, Iss , Pp 100425- (2023)
Recently, tannic acid (TA) has been attracting attention as a component for supramolecular hydrogels. In fact, TA was reported to form viscous hydrogels with polyethylene oxide (PEO) (∼10 kDa), a typical macromolecule; however, little is known abou
Externí odkaz:
https://doaj.org/article/fe99bc60e3f844dc9361818203adc760
Autor:
Yusei Yamada, Madoka Fukaura‐Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 8, Pp n/a-n/a (2023)
Abstract Background Niemann–Pick disease type C (NPC) is a fatal neurodegenerative disorder caused by abnormal intracellular cholesterol trafficking. Cyclodextrins (CDs), the most promising therapeutic candidates for NPC, but with concerns about ot
Externí odkaz:
https://doaj.org/article/4e90738b28c44e4c9ddaf53a1c5805b3
Autor:
Toru Taharabaru, Takuya Kihara, Risako Onodera, Tetsuya Kogo, Yuting Wen, Jun Li, Keiichi Motoyama, Taishi Higashi
Publikováno v:
Materials Today Bio, Vol 20, Iss , Pp 100690- (2023)
Various biopharmaceuticals, such as nucleic acids, proteins, and genome-editing molecules, have been developed. Generally, carriers are prepared for each biopharmaceutical to deliver it intracellularly; thus, the applications of individual carriers a
Externí odkaz:
https://doaj.org/article/71935fed799b4a528e177a6af4e51dec
Autor:
Yasushi Kubota, Toshimi Hoshiko, Taishi Higashi, Keiichi Motoyama, Seiji Okada, Shinya Kimura
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16720 (2023)
Acute myeloid leukemia (AML) is a heterogenous myeloid neoplasm that remains challenging to treat. Because intensive conventional chemotherapy reduces survival rates in elderly patients, drugs with lower toxicity and fewer side effects are needed urg
Externí odkaz:
https://doaj.org/article/063c34b634ea46c9ae625827c2de501b
Autor:
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Akira Ishii, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113698- (2022)
Niemann–Pick disease type C (NPC) is a fatal disorder with abnormal intracellular cholesterol trafficking resulting in neurodegeneration and hepatosplenomegaly. A cyclic heptasaccharide with different degrees of substitution of 2-hydroxypropyl grou
Externí odkaz:
https://doaj.org/article/226ae786b7754b9d9a6eb4f06117e2c0
Autor:
Yusuke Suzuki, Tomoya Hayashi, Ryoma Yokoyama, Fumika Nakagawa, Joe Inoue, Taishi Higashi, Risako Onodera, Keiichi Motoyama
Publikováno v:
FEBS Open Bio, Vol 11, Iss 9, Pp 2619-2630 (2021)
Eosinophilic asthma is a form of bronchial asthma that is caused by the pulmonary infiltration of eosinophils and accounts for approximately half of the patients with severe asthma. Several cell types of the immune system in synergy with the epitheli
Externí odkaz:
https://doaj.org/article/40e79bc36bd1488a8fc3b0c09d2b6a05
Autor:
Kosei Utatsu, Tetsuya Kogo, Toru Taharabaru, Risako Onodera, Keiichi Motoyama, Taishi Higashi
Publikováno v:
Materials Today Bio, Vol 12, Iss , Pp 100160- (2021)
We herein developed a transformable mixing-type material for reversible PEGylation of protein drugs using a supramolecular backbone polymer, that is, polyrotaxane possessing both amino groups and PEG chains (PEG–NH2–PRX). We expected that PEG–N
Externí odkaz:
https://doaj.org/article/911dbd1679654855943e1bb04ad5934c
Autor:
Tomoya, Hayashi, Fumika, Nakagawa, Yoshitaka, Ohno, Yusuke, Suzuki, Honatsu, Ishiki, Risako, Onodera, Taishi, Higashi, Yoshihisa, Shimamura, Hiroshi, Itou, Yoichiro, Iwase, Hidetoshi, Arima, Keiichi, Motoyama
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 181:113-121
Recent viral pandemics have increased global demand for vaccines. However, the supply of effective and safe vaccine not only to developed countries but also developing countries with inadequate storage equipment is still challenging due to the lack o
Autor:
Masamichi Inoue, Kyosuke Muta, Ahmed Fouad Abdelwahab Mohammed, Risako Onodera, Taishi Higashi, Kenta Ouchi, Mitsuharu Ueda, Yukio Ando, Hidetoshi Arima, Hirofumi Jono, Keiichi Motoyama
Publikováno v:
Biological and Pharmaceutical Bulletin. 45:1660-1668