Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tairan, Qin"'
Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis
Autor:
Fei Kang, Li Xie, Tairan Qin, Yifan Miao, Youhou Kang, Toshimasa Takahashi, Tao Liang, Huanli Xie, Herbert Y. Gaisano
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Kang and colleagues find that plasma membrane flipping of Syntaxin-2 from inside (inhibitory) to outside (relief of inhibition) of pancreatic β-cells helps fine-tune insulin secretion. Increasing this flipping efficiency can alleviate the impaired i
Externí odkaz:
https://doaj.org/article/448e49692c8f483fabaa7e2203e39286
Autor:
Tairan Qin, Tao Liang, Dan Zhu, Youhou Kang, Li Xie, Subhankar Dolai, Shuzo Sugita, Noriko Takahashi, Claes-Goran Ostenson, Kate Banks, Herbert Y. Gaisano
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 262-274 (2017)
Reduced pancreatic islet levels of Munc18a/SNARE complex proteins have been postulated to contribute to the deficient glucose-stimulated insulin secretion (GSIS) in type-2 diabetes (T2D). Whereas much previous work has purported Munc18a/SNARE complex
Externí odkaz:
https://doaj.org/article/145a7b2011d04b458ebc56f90b2ef7b3
Autor:
Jitender Yadav, Tao Liang, Tairan Qin, Nayanan Nathan, Katherine J.P. Schwenger, Lauren Pickel, Li Xie, Helena Lei, Daniel A. Winer, Heather Maughan, Susan J. Robertson, Minna Woo, Wendy Lou, Kate Banks, Timothy Jackson, Allan Okrainec, Susy S. Hota, Susan M. Poutanen, Hoon-Ki Sung, Johane P. Allard, Dana J. Philpott, Herbert Y. Gaisano
Publikováno v:
Cell Reports Medicine. 4:101051
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c214a7f3d0dcc5691c56cb2d9d24741
https://doi.org/10.1016/j.xcrm.2023.101051
https://doi.org/10.1016/j.xcrm.2023.101051
Autor:
Li Xie, Subhankar Dolai, Youhou Kang, Tao Liang, Huanli Xie, Tairan Qin, Lu Yang, Liangyi Chen, Herbert Y Gaisano
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147862 (2016)
Syntaxin (Syn)-1A mediates exocytosis of predocked insulin-containing secretory granules (SGs) during first-phase glucose-stimulated insulin secretion (GSIS) in part via its interaction with plasma membrane (PM)-bound L-type voltage-gated calcium cha
Externí odkaz:
https://doaj.org/article/63bfa688542b47c09d74086078d09441
Autor:
jitender Yadav, Tao Liang, Tairan Qin, Nayanan N. Nathan, Katherine J.P Schwenger, Lauren Pickel, Li Xie, Helena Lei, Daniel A. Winer, Heather Maughan, Susan J. Robertson, Minna Woo, Wendy Y. W. Lou, Kate Banks, Timothy Jackson, Allan Okrainec, Susy S. Hota, Susan M. Poutanen, Hoon-Ki Sung, Johane P. Allard, Dana J. Philpott, Herbert Y. Gaisano
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ebafbe0097b0f4872422418480b578
https://doi.org/10.2139/ssrn.4170190
https://doi.org/10.2139/ssrn.4170190
Autor:
Li Xie, Tao Liang, Yi-Fan Miao, Tairan Qin, Mark S. Cattral, Subhankar Dolai, Huanli Xie, Toshimasa Takahashi, Paul A Roche, Erin Winter, Justin Manuel, Fei Kang, Herbert Y. Gaisano, Youhou Kang
Publikováno v:
Autophagy
Intrapancreatic trypsin activation by dysregulated macroautophagy/autophagy and pathological exocytosis of zymogen granules (ZGs), along with activation of inhibitor of NFKB/NF-κB kinase (IKK) are necessary early cellular events in pancreatitis. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa951c98b56f75b70b3873d8fb6ee55
Autor:
Tao Liang, Dan Zhu, Herbert Y. Gaisano, Dafna Greitzer-Antes, Subhankar Dolai, Youhou Kang, Tairan Qin, Yan He, Li Xie, Alexandre B. Hardy, Fei Kang, Huanli Xie
Publikováno v:
Journal of Biological Chemistry. 293:6893-6904
The voltage-dependent K+ (Kv) channel Kv2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, Kv2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is independent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f474510ff42f77d5630196c0930867
https://doi.org/10.1074/jbc.ra118.002703
https://doi.org/10.1074/jbc.ra118.002703
Autor:
Kacey J. Prentice, Tao Liang, Youhou Kang, Michael B. Wheeler, Subhankar Dolai, Herbert Y. Gaisano, Lucy R. Osborne, Dan Zhu, Tairan Qin, Li Xie
Publikováno v:
Journal of Biological Chemistry. 292:2203-2216
In type-2 diabetes (T2D), severely reduced islet syntaxin-1A (Syn-1A) levels contribute to insulin secretory deficiency. We generated β-cell-specific Syn-1A-KO (Syn-1A-βKO) mice to mimic β-cell Syn-1A deficiency in T2D. Glucose tolerance tests sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9184e45a2540b81764af5a033556cd71
https://doi.org/10.1074/jbc.m116.769885
https://doi.org/10.1074/jbc.m116.769885
Autor:
Deborah C. Rubin, Jakob Bondo Hansen, Subhankar Dolai, Herbert Y. Gaisano, Tairan Qin, Huanli Xie, Youhou Kang, Tao Liang, Lucy R. Osborne, Li Xie, Dan Zhu
Publikováno v:
Diabetes
Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df4435bd3122515c0d2f45a8266cd78
https://doi.org/10.2337/db16-0636
https://doi.org/10.2337/db16-0636
Autor:
Robert K. Baker, Youhou Kang, Dan Zhu, Claes-Göran Östenson, Herbert Y. Gaisano, Fei Kang, Subhankar Dolai, Timothy J. Kieffer, Daorong Feng, Jeffrey E. Pessin, Li Xie, Tairan Qin, Kate Banks, Dafna Greitzer-Antes, Eva Tudurí, Tao Liang
Publikováno v:
JCI insight. 5(3)
SNAP23 is the ubiquitous SNAP25 isoform that mediates secretion in non-neuronal cells, similar to SNAP25 in neurons. However, some secretory cells like pancreatic islet β cells contain an abundance of both SNAP25 and SNAP23, where SNAP23 is believed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9847da5d9c0879494e267ba431aa3cd
https://pubmed.ncbi.nlm.nih.gov/32051343
https://pubmed.ncbi.nlm.nih.gov/32051343