Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Taira Kiyota"'
Autor:
Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Externí odkaz:
https://doaj.org/article/d082e4930596459b8898e21f8ca1f16d
Autor:
Ahmed Mamai, Anh M. Chau, Brian J. Wilson, Iain D. Watson, Babu B. Joseph, Pandiaraju R. Subramanian, Monzur M. Morshed, Justin A. Morin, Michael A. Prakesch, Tianbao Lu, Pete Connolly, Douglas A. Kuntz, Neil C. Pomroy, Gennady Poda, Kong Nguyen, Richard Marcellus, Graig Strathdee, Brigitte Theriault, Ratheesh Subramaniam, Mohammed Mohammed, Ayome Abibi, Manuel Chan, Jeffrey Winston, Taira Kiyota, Elijus Undzys, Ahmed Aman, Nigel Austin, Marc Du Jardin, Kathryn Packman, Ulrike Phillippar, Riccardo Attar, James Edwards, Jeff O’Meara, David E. Uehling, Rima Al-awar, Gilbert G. Privé, Methvin B. Isaac
Publikováno v:
ACS Medicinal Chemistry Letters. 14:199-210
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7baafefe694004e06c601f99ee7e496
https://doi.org/10.1021/acsmedchemlett.2c00502
https://doi.org/10.1021/acsmedchemlett.2c00502
Autor:
Lauren Katz, Michael Woolman, Taira Kiyota, Layla Pires, Mark Zaidi, Stefan O.P. Hofer, Wey Leong, Brad G. Wouters, Danny Ghazarian, An-Wen Chan, Howard J. Ginsberg, Ahmed Aman, Brian C. Wilson, Hal K. Berman, Arash Zarrine-Afsar
Publikováno v:
Analytical Chemistry. 94:16821-16830
Currently, a large number of skin biopsies are taken for each true skin cancer case detected, creating a need for a rapid, high sensitivity, and specificity skin cancer detection tool to reduce the number of unnecessary biopsies taken from benign tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed3833037ccd437e6e0f25b83486922
https://doi.org/10.1021/acs.analchem.2c03918
https://doi.org/10.1021/acs.analchem.2c03918
Autor:
Arash Zarrine-Afsar, Howard J. Ginsberg, James T. Rutka, Michael D. Taylor, Ahmed Aman, Sunit Das, David G. Munoz, Megan Wu, Betty Luu, Taira Kiyota, Isabelle Ferry, Claudia M. Kuzan-Fischer, Michael Woolman
Table S1. Sampling events, signal strength and signal persistence of data points used to build the MB subgroup model; Table S2. MB subgroup classifying peak list from PCA-LDA modeling;Table S3. PCA-LDA prediction results of the blind MB subgrouping t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04841eb043ace7a7e030b66cb84c0ec4
https://doi.org/10.1158/0008-5472.22423920
https://doi.org/10.1158/0008-5472.22423920
Autor:
Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong
Publikováno v:
Journal of Medicinal Chemistry. 64:15017-15036
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f2b58e16e289efc68af8b3a1671546
https://doi.org/10.1021/acs.jmedchem.1c00889
https://doi.org/10.1021/acs.jmedchem.1c00889
Autor:
Junchao Tong, Iain D. G. Watson, Methvin Isaac, Emily Murrell, Ahmed Aman, Neil Vasdev, Taira Kiyota, David Smil
Publikováno v:
ACS Medicinal Chemistry Letters. 12:846-850
Mutations in the gene encoding activin receptor-like kinase 2 (ALK2) are implicated in the pathophysiology of a pediatric brainstem cancer, diffuse intrinsic pontine glioma (DIPG). Inhibitors of ALK2 that cross the blood-brain barrier have been propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c8099703a0402af62cb019ae550fc9a
https://doi.org/10.1021/acsmedchemlett.1c00127
https://doi.org/10.1021/acsmedchemlett.1c00127
Autor:
Taira Kiyota, Isabelle Ferry, Mark Zaidi, Howard J. Ginsberg, James T. Rutka, Lauren Katz, Georgia Gopinath, Chris McIntosh, Siham Amara-Belgadi, Craig Daniels, Fred Fu, Claudia M. Kuzan-Fischer, Arash Zarrine-Afsar, Ahmed Aman, Brad Wouters, Kaitlyn Peters, Trevor D. McKee, Michael Woolman
Publikováno v:
Analytical Chemistry. 93:4408-4416
Spatially resolved ambient mass spectrometry imaging methods have gained popularity to characterize cancer sites and their borders using molecular changes in the lipidome. This utility, however, is predicated on metabolic homogeneity at the border, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4297d5fba5870de6bc430e3e0d2b0099
https://doi.org/10.1021/acs.analchem.0c04129
https://doi.org/10.1021/acs.analchem.0c04129
Autor:
Methvin Isaac, Rima Al-awar, Deeba Ensan, Dimitrios Panagopoulos, Jeff A O'Meara, Eleanor Williams, Roslin Adamson, Carlos Zepeda-Velázquez, David Smil, Alex N. Bullock, Ahmed Aman, Taira Kiyota, Jong Fu Wong, Owen G Roberts, Aled M. Edwards
Publikováno v:
Journal of Medicinal Chemistry
Diffuse intrinsic pontine glioma is an aggressive pediatric cancer for which no effective chemotherapeutic drugs exist. Analysis of the genomic landscape of this disease has led to the identification of the serine/threonine kinase ALK2 as a potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f2976a14056fd6ade9b90ba5c1f9b9
http://europepmc.org/articles/PMC8213057
http://europepmc.org/articles/PMC8213057
Autor:
Sumera Perveen, Carlos A. Zepeda-Velázquez, David McLeod, Richard Marcellus, Mohammed Mohammed, Megha Abbey, Deeba Ensan, Dimitrios Panagopoulos, Viacheslav Trush, Elisa Gibson, Aiping Dong, Levon Halabelian, Gennady Poda, Julie Owen, Ahmed Aman, Taira Kiyota, Ahmed Mamai, Cheryl H. Arrowsmith, Peter J. Brown, Matthieu Schapira, Rima Al-awar, Masoud Vedadi
RBBP4 is a nuclear WD40 motif-containing protein widely implicated in various cancers and a putative drug target. It interacts with multiple proteins within diverse complexes such as nucleosome remodeling and deacetylase (NuRD) complex and polycomb r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44cf4448a4ef25f58c7154a98ab95c5c
https://doi.org/10.1101/2022.01.05.475077
https://doi.org/10.1101/2022.01.05.475077
Autor:
John David Konda, Craig Strathdee, Taira Kiyota, David Uehling, Kim Chan Chung, Richard Marcellus, Rima Al-awar, Methvin Isaac, Rodger E. Tiedemann, Chungyee Leung-Hagesteijn, Spencer Ler, Ahmed Aman, Michael Prakesch, Carly Griffin, Andrew X Zhang, Ayome Abibi, Gennady Poda, Babu Joseph, Julie Grouleff, Ratheesh Subramaniam
Publikováno v:
Journal of medicinal chemistry. 64(15)
Both previous and additional genetic knockdown studies reported herein implicate G protein-coupled receptor kinase 6 (GRK6) as a critical kinase required for the survival of multiple myeloma (MM) cells. Therefore, we sought to develop a small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf89532768b7792c70f9b83b4ace17c
https://pubmed.ncbi.nlm.nih.gov/34963044
https://pubmed.ncbi.nlm.nih.gov/34963044