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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

Autor: WILSON, David, Deacon, AM, Duncton, MAJ, Pellicena, P, Georgiadis, MM, Yeh, AP, Arvai, AS, Moiani, D, Tainer, JA, Das , D

Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and ultimately cell fate determination, playing a central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______105::7068aabd1648daba90c75c8e39e205e6
http://hdl.handle.net/1942/35805

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Phosphate steering by Flap Endonuclease 1 promotes 5 '-flap specificity and incision to prevent genome instability (vol 8, 15855, 2017)

Autor: Tsutakawa, SE, Thompson, MJ, Arvai, AS, Neil, AJ, Shaw, SJ, Algasaier, SI, Kim, JC, Finger, D, Jardine, E, Gotham, VJB, Sarker, AH, Her, MZ, Rashid, F, Hamdan, SM, Mirkin, SM, Grasby, JA, Tainer, JA

Publikováno v: Tsutakawa, SE; Thompson, MJ; Arvai, AS; Neil, AJ; Shaw, SJ; Algasaier, SI; et al.(2017). Phosphate steering by Flap Endonuclease 1 promotes 5 '-flap specificity and incision to prevent genome instability (vol 8, 15855, 2017). NATURE COMMUNICATIONS, 8. doi: 10.1038/ncomms16145. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/447808sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::8e139ef5e2e6b52bb78d83a6a3d462bb
http://www.escholarship.org/uc/item/447808sk

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Charging of Proteins in Native Mass Spectrometry

Autor: Susa, AC, Xia, Z, Tang, HYH, Tainer, JA, Williams, ER

Publikováno v: Journal of the American Society for Mass Spectrometry, vol 28, iss 2
Susa, AC; Xia, Z; Tang, HYH; Tainer, JA; & Williams, ER. (2017). Charging of Proteins in Native Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 28(2), 332-340. doi: 10.1007/s13361-016-1517-7. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7r66h9m4

© 2016, American Society for Mass Spectrometry. Factors that influence the charging of protein ions formed by electrospray ionization from aqueous solutions in which proteins have native structures and function were investigated. Protein ions rangin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::047d686cec7e7cf1f9ea8330fd64a1b4
https://escholarship.org/uc/item/7r66h9m4

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Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex

Autor: Daniel Aceytuno, R, Piett, CG, Havali-Shahriari, Z, Edwards, RA, Rey, M, Ye, R, Javed, F, Fang, S, Mani, R, Weinfeld, M, Hammel, M, Tainer, JA, Schriemer, DC, Lees-Miller, SP, Mark Glover, JN

Publikováno v: Daniel Aceytuno, R; Piett, CG; Havali-Shahriari, Z; Edwards, RA; Rey, M; Ye, R; et al.(2017). Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex. Nucleic Acids Research, 45(10), 6238-6251. doi: 10.1093/nar/gkx275. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/8vv1h2hs

© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. Non-homologous end joining (NHEJ) repairs DNA double strand breaks in non-cycling eukaryotic cells. NHEJ relies on polynucleotide kinase/phosphatase (PNK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::11460a66b20de394958b302d981018ab
http://www.escholarship.org/uc/item/8vv1h2hs

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Exploring the repeat protein universe through computational protein design

Autor: Brunette, TJ, Parmeggiani, F, Huang, PS, Bhabha, G, Ekiert, DC, Tsutakawa, SE, Hura, GL, Tainer, JA, Baker, D

Publikováno v: Nature, vol 528, iss 7583
Brunette, TJ; Parmeggiani, F; Huang, PS; Bhabha, G; Ekiert, DC; Tsutakawa, SE; et al.(2015). Exploring the repeat protein universe through computational protein design. Nature, 528(7583), 580-584. doi: 10.1038/nature16162. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/1pb2b52f

© 2015 Macmillan Publishers Limited. All rights reserved. A central question in protein evolution is the extent to which naturally occurring proteins sample the space of folded structures accessible to the polypeptide chain. Repeat proteins composed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bae418dc5b9ea176a6fbfc91abe3347f
https://escholarship.org/uc/item/1pb2b52f

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ELUCIDATING THE STRUCTURAL CHEMISTRY OF GLYCOSAMINOGLYCAN RECOGNITION BY PROTEIN-C INHIBITOR

Autor: KUHN, LA, GRIFFIN, JH, FISHER, CL, GREENGARD, JS, BOUMA, BN, Espana, F., TAINER, JA

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::16bef6638211ac781d3cd239bbc30554
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4263

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