Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Taina T Immonen"'
Autor:
Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012135 (2024)
The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is stopped-is the primary barrier to eradicating HIV. We used time to initiation of ART during p
Externí odkaz:
https://doaj.org/article/65fa1fcf2796486fb2e2ddf45842dec6
Autor:
Taina T Immonen, Christine M Fennessey, Leslie Lipkey, Abigail Thorpe, Gregory Q Del Prete, Jeffrey D Lifson, Miles P Davenport, Brandon F Keele
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009686 (2021)
Analytical treatment interruptions (ATIs) of antiretroviral therapy (ART) play a central role in evaluating the efficacy of HIV-1 treatment strategies targeting virus that persists despite ART. However, it remains unclear if ATIs alter the rebound-co
Externí odkaz:
https://doaj.org/article/dd96b32ade714ff6afc0bdece6c9b2eb
Autor:
Sean P O'Brien, Adrienne E Swanstrom, Amarendra Pegu, Sung-Youl Ko, Taina T Immonen, Gregory Q Del Prete, Christine M Fennessey, Jason Gorman, Kathryn E Foulds, Stephen D Schmidt, Nicole Doria-Rose, Carolyn Williamson, Theodora Hatziioannou, Paul D Bieniasz, Hui Li, George M Shaw, John R Mascola, Richard A Koup, Peter D Kwong, Jeffrey D Lifson, Mario Roederer, Brandon F Keele
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007632 (2019)
Chimeric Simian-Human Immunodeficiency Viruses (SHIVs) are an important tool for evaluating anti-HIV Env interventions in nonhuman primate (NHP) models. However, most unadapted SHIVs do not replicate well in vivo limiting their utility. Furthermore,
Externí odkaz:
https://doaj.org/article/223d0101fda54e459f18cac090f5311b
Autor:
Christine M Fennessey, Mykola Pinkevych, Taina T Immonen, Arnold Reynaldi, Vanessa Venturi, Priyanka Nadella, Carolyn Reid, Laura Newman, Leslie Lipkey, Kelli Oswald, William J Bosche, Matthew T Trivett, Claes Ohlen, David E Ott, Jacob D Estes, Gregory Q Del Prete, Jeffrey D Lifson, Miles P Davenport, Brandon F Keele
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006359 (2017)
HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many individual infection events, which are difficult to independently track using conventional seque
Externí odkaz:
https://doaj.org/article/12624c7f2b5640c181fb68da867a31e1
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004625 (2015)
HIV-1 is subject to immune pressure exerted by the host, giving variants that escape the immune response an advantage. Virus released from activated latent cells competes against variants that have continually evolved and adapted to host immune press
Externí odkaz:
https://doaj.org/article/31467aeb30fc4c7e9dcf3c44c5143699
Autor:
Michael Hull, Jacob D. Estes, Randy Fast, Joshua A. Kramer, Laura Newman, Rodney Wiles, Rebecca Shoemaker, William J. Bosche, Claire Deleage, Christine M. Fennessey, Tyler Malys, James A. Thomas, Charles M. Trubey, Lorna Silipino, Vicky Coalter, Gregory Q. Del Prete, Jeffrey D. Lifson, Cathi Pyle, Duncan Donohue, Adam Wiles, Jacob Kiser, Brandon F. Keele, David R. Morcock, Adrienne E. Swanstrom, Taina T. Immonen, Kelli Oswald, Matthew W. Breed
Publikováno v:
J Clin Invest
The effectiveness of virus-specific strategies, including administered HIV-specific mAbs, to target cells that persistently harbor latent, rebound-competent HIV genomes during combination antiretroviral therapy (cART) has been limited by inefficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b7bbba818f529be5aff422e155c2c2
https://pubmed.ncbi.nlm.nih.gov/33465055
https://pubmed.ncbi.nlm.nih.gov/33465055
Autor:
Brandon F. Keele, Justin B. Lack, Vickie Marshall, Ramya Ramaswami, Nicholas C Fisher, Elena M. Cornejo Castro, Kathryn Lurain, Denise Whitby, Taina T. Immonen, Thomas S. Uldrick, Mark N. Polizzotto, Nazzarena Labo, Robert Yarchoan
Publikováno v:
Virus Evol
Kaposi sarcoma herpesvirus (KSHV) is the etiological agent of three malignancies, Kaposi sarcoma, primary effusion lymphoma and KSHV-associated multicentric Castelman disease. KSHV infected patients may also have an interleukin six-related KSHV-assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233377731e7748c453ea39bc4b9d361f
https://europepmc.org/articles/PMC7474928/
https://europepmc.org/articles/PMC7474928/
Autor:
Brandon F. Keele, Taina T. Immonen, Jeffrey D. Lifson, Gregory Q. Del Prete, Christine M. Fennessey, Celine Camus, Miles P. Davenport, Carolyn Reid
Publikováno v:
Proc Natl Acad Sci U S A
The rapidity of replication coupled with a high mutation rate enables HIV to evade selective pressures imposed by host immune responses. Investigating the ability of HIV to escape different selection forces has generally relied on population-level me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a407fc68f5154eae44a0f198acda38
https://pubmed.ncbi.nlm.nih.gov/31843933
https://pubmed.ncbi.nlm.nih.gov/31843933
Autor:
Sirish Khanal, Gregory Q. Del Prete, Brandon F. Keele, Abigail Thorpe, Louis J. Picker, Julian W. Bess, Taina T. Immonen, Sean P. O’Brien, Miles P. Davenport, Adrienne E. Swanstrom, Rodman Smith, Carolyn Reid, Christine M. Fennessey, Afam A. Okoye, Jeffrey D. Lifson
Publikováno v:
J Virol
Genetically barcoded viral populations are powerful tools for evaluating the overall viral population structure as well as assessing the dynamics and evolution of individual lineages in vivo over time. Barcoded viruses are generated by inserting a sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afdd7e486e1a08d165a892a1a9e3c3a
https://europepmc.org/articles/PMC6912102/
https://europepmc.org/articles/PMC6912102/
Autor:
Celine Camus, Jeremy Smedley, Arnold Reynaldi, Christine M. Fennessey, Sean P. O’Brien, Laura Newman, Taina T. Immonen, Gregory Q. Del Prete, Miles P. Davenport, Jessica M. Conway, Claire Deleage, Brandon F. Keele, Carolyn Reid, Jeffrey D. Lifson, Timothy E. Schlub, Jacob D. Estes, Leslie Lipkey
Publikováno v:
Science Advances
Viral dynamics and host responses to vaginal infection of SIV in nonhuman primates may identify viral vulnerabilities for HIV.
Understanding HIV transmission is critical to guide the development of prophylactic interventions to prevent infection
Understanding HIV transmission is critical to guide the development of prophylactic interventions to prevent infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c58abf37d749f8a4f8f155d02c8f24
http://europepmc.org/articles/PMC6541462
http://europepmc.org/articles/PMC6541462