Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Taina, Pihlajaniemi"'
Autor:
Riitta Kaarteenaho, Oula Norman, Jarkko Koivunen, Antti M Salo, Joni M Mäki, Johanna Myllyharju, Taina Pihlajaniemi, Anne Heikkinen
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usu
Externí odkaz:
https://doaj.org/article/ac36a204554a4f418330e724704750ba
Autor:
Raman Devarajan, Valerio Izzi, Hellevi Peltoketo, Gunilla Rask, Saila Kauppila, Marja-Riitta Väisänen, Heli Ruotsalainen, Guillermo Martínez-Nieto, Sanna-Maria Karppinen, Timo Väisänen, Inderjeet Kaur, Jussi Koivunen, Takako Sasaki, Robert Winqvist, Aki Manninen, Fredrik Wärnberg, Malin Sund, Taina Pihlajaniemi, Ritva Heljasvaara
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
The tumor extracellular matrix (ECM) critically regulates cancer progression and treatment response. Expression of the basement membrane component collagen XVIII (ColXVIII) is induced in solid tumors, but its involvement in tumorigenesis has remained
Externí odkaz:
https://doaj.org/article/e957e170320b4816a30b9afccd36d3ca
Autor:
Guillermo A. Martínez-Nieto, Hanna-Riikka Teppo, Noora Petrelius, Valerio Izzi, Raman Devarajan, Tiina Petäistö, Hengshuo Liu, Kris S. Kim, Sanna-Maria Karppinen, Heli Ruotsalainen, Jarkko Koivunen, Joni M. Mäki, Gilbert C. Walker, Taina Pihlajaniemi, Donald Gullberg, Ritva Heljasvaara
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing. The expression of the α11 is upregulated in cancer-associated fibroblasts (CAFs) in vario
Externí odkaz:
https://doaj.org/article/a42f98c2b506481b89f70daf56c95400
Autor:
Iida Jääskeläinen, Tiina Petäistö, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1412 (2023)
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose tissue (AT) often leads to its malfunction and to a systemic metabolic dysfu
Externí odkaz:
https://doaj.org/article/8def20d19ee748549177ab050ddad63a
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0276215 (2022)
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with a poor prognosis and few treatment options. In the most widely used experimental model for this disease, bleomycin is administered into the lungs of mice, causing a reaction of inflamm
Externí odkaz:
https://doaj.org/article/53ad385b25ea4a57afa6042d55f2ba6a
Autor:
Sandrine Bretaud, Emilie Guillon, Sanna-Maria Karppinen, Taina Pihlajaniemi, Florence Ruggiero
Publikováno v:
Matrix Biology Plus, Vol 6, Iss , Pp 100023- (2020)
Type XV collagen is a non-fibrillar collagen that is associated with basement membranes and belongs to the multiplexin subset of the collagen superfamily. Collagen XV was initially studied because of its sequence homology with collagen XVIII/endostat
Externí odkaz:
https://doaj.org/article/accb4768a4bc4fba8df5b094408259e1
Autor:
Hui Zhang, Tricia Fredericks, Gaofeng Xiong, Yifei Qi, Piotr G. Rychahou, Jia-Da Li, Taina Pihlajaniemi, Wei Xu, Ren Xu
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-14 (2018)
Abstract Background Increased collagen expression and deposition are associated with cancer progression and poor prognosis in breast cancer patients. However, function and regulation of membrane-associated collagen in breast cancer have not been dete
Externí odkaz:
https://doaj.org/article/9b49601e19bb40298c4985ebcc9edb10
Autor:
Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina Pihlajaniemi
Publikováno v:
Leukemia Research Reports, Vol 9, Iss , Pp 9-13 (2018)
Relapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet b
Externí odkaz:
https://doaj.org/article/9859af782f3b48f3aa892fb6e672708a
Autor:
Guillermo Martínez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9978 (2021)
Basement membrane (BM) zone-associated collagen XV (ColXV) has been shown to suppress the malignancy of tumour cells, and its restin domain can inhibit angiogenesis. In human breast cancer, as well as in many other human carcinomas, ColXV is lost fro
Externí odkaz:
https://doaj.org/article/ed07102488da46b6bfacad73bf12acf6
Autor:
Juho Kontio, Valeria Rolle Soñora, Vilma Pesola, Rijuta Lamba, Annalena Dittmann, Ander Diaz Navarro, Jarkko Koivunen, Taina Pihlajaniemi, Valerio Izzi
Publikováno v:
Scopus
The extracellular matrix (ECM) is a three-dimensional network of proteins of diverse nature, whose interactions are essential to provide tissues with the correct mechanical and biochemical cues they need for proper development and homeostasis. Change