Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Taikangxiang Yun"'
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibi
Externí odkaz:
https://doaj.org/article/b684729291084fc88b9bcb7115c6f1a3
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Vol 8 (2020)
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0290fa4ee264dd2d1c23450cc6026ff
http://europepmc.org/articles/PMC7309560
http://europepmc.org/articles/PMC7309560
Autor:
Tan Qin, Chuanmao Zhang, Fangjin Chen, Xiao Guo, Luhua Lai, Taikangxiang Yun, Xiaolong Zhuo, Ying Liu
Publikováno v:
Journal of Medicinal Chemistry. 59:7089-7096
Polo-like kinase 1(Plk1) is vital for cell mitosis and has been identified as anticancer target. Its polo-box domain (PBD) mediates substrate binding, blocking of which may offer selective Plk1 inhibition compared to kinase domain inhibitors. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191523ff760a4a6534e3ca86c3d7db10
https://doi.org/10.1021/acs.jmedchem.6b00261
https://doi.org/10.1021/acs.jmedchem.6b00261
Publikováno v:
ChemMedChem. 11:713-717
Polo-like kinase 1 (Plk1) is an evolutionarily conserved serine/threonine kinase, and its N-terminal kinase domain (KD) controls cell signaling through phosphorylation. Inhibitors of Plk1 are potential anticancer drugs. Most known Plk1 KD inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a08e91786ac06dd7672f7d4e67f584a
https://doi.org/10.1002/cmdc.201600051
https://doi.org/10.1002/cmdc.201600051
Publikováno v:
European journal of medicinal chemistry. 124
Thiourea derivatives have drawn much attention for their latent capacities of biological activities. In this study, we designed acylthiourea compounds as polo-like kinase 1 (Plk1) polo-box domain (PBD) inhibitors. A series of acylthiourea derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743f8e41cdb9628c8be566fe3e05f103
https://pubmed.ncbi.nlm.nih.gov/27592392
https://pubmed.ncbi.nlm.nih.gov/27592392