Zobrazeno 1 - 10
of 710
pro vyhledávání: '"Taiji Adachi"'
Autor:
Shinsei Yambe, Yuki Yoshimoto, Kazutaka Ikeda, Koichiro Maki, Aki Takimoto, Akihide Tokuyama, Shinnosuke Higuchi, Xinyi Yu, Kenta Uchibe, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Kotaro Tanimoto, Gen Kondoh, Masataka Kasahara, Toshihide Mizoguchi, Denitsa Docheva, Taiji Adachi, Chisa Shukunami
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Fibrocartilaginous entheses consist of tendons, unmineralized and mineralized fibrocartilage, and subchondral bone, each exhibiting varying stiffness. Here we examined the functional role of sclerostin, expressed in mature mineralized fibrochondrocyt
Externí odkaz:
https://doaj.org/article/427052bd41564fbcaaa067f05c89e21b
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract DNA underwinding (untwisting) is a crucial step in transcriptional activation. DNA underwinding occurs between the site where torque is generated by RNA polymerase (RNAP) and the site where the axial rotation of DNA is constrained. However,
Externí odkaz:
https://doaj.org/article/5e892ba08af742f4a7fdf20a7c5acf73
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract A new marker reflecting the pathophysiology of chronic kidney disease (CKD) has been desired for its therapy. In this study, we developed a virtual space where data in medical words and those of actual CKD patients were unified by natural la
Externí odkaz:
https://doaj.org/article/741e64214a9346a686127f9d5a2925b7
Autor:
Kazunori Sunadome, Alek G. Erickson, Delf Kah, Ben Fabry, Csaba Adori, Polina Kameneva, Louis Faure, Shigeaki Kanatani, Marketa Kaucka, Ivar Dehnisch Ellström, Marketa Tesarova, Tomas Zikmund, Jozef Kaiser, Steven Edwards, Koichiro Maki, Taiji Adachi, Takuya Yamamoto, Kaj Fried, Igor Adameyko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Formation of oriented myofibrils is a key event in musculoskeletal development. However, the mechanisms that drive myocyte orientation and fusion to control muscle directionality in adults remain enigmatic. Here, we demonstrate that the deve
Externí odkaz:
https://doaj.org/article/aca68f844c204077a1afc1227a7f600c
Autor:
Shunsuke Kawai, Junko Sunaga, Sanae Nagata, Megumi Nishio, Masayuki Fukuda, Takeshi Kamakura, Liping Sun, Yonghui Jin, Satoko Sakamoto, Akira Watanabe, Shuichi Matsuda, Taiji Adachi, Junya Toguchida
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological events during nodule formation are unknown. Here we perf
Externí odkaz:
https://doaj.org/article/dbb57962a6144ea8b83bc0dd40be197a
Publikováno v:
PLOS Digital Health, Vol 2, Iss 1, p e0000188 (2023)
Chronic kidney disease (CKD) patients have high risks of end-stage kidney disease (ESKD) and pre-ESKD death. Therefore, accurately predicting these outcomes is useful among CKD patients, especially in those who are at high risk. Thus, we evaluated wh
Externí odkaz:
https://doaj.org/article/84cb4ea61898460182a5fc645e28236b
Autor:
Nobuhiko NAKAO, Taiji ADACHI
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 17, Iss 4, Pp 22-00267-22-00267 (2022)
To understand adaptive bone remodeling in response to external mechanical stimuli, researchers have elucidated the mechanisms of mechanosensing and mechanoresponse through in vitro experiments targeting subcellular components from molecules to organe
Externí odkaz:
https://doaj.org/article/203ff41ec69340bea3b423a3074491a7
Publikováno v:
Journal of Biomechanical Science and Engineering, Vol 17, Iss 3, Pp 22preface1-22preface1 (2022)
Externí odkaz:
https://doaj.org/article/c702cc536b7a42bf9dbe264d76c800cb
Autor:
Jeonghyun Kim, Taiji Adachi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Osteocytes are mechanosensory commander cells to regulate bone remodeling throughout the lifespan. While the osteocytes are known as terminally differentiated cells derived from mesenchymal stem cells, the detailed mechanisms of osteocyte di
Externí odkaz:
https://doaj.org/article/2425ffd5bce84a2d9252cadcd93ffc76
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Osteocytes differentiated from osteoblasts play significant roles as mechanosensors in modulating the bone remodeling process. While the well-aligned osteocyte network along the trabeculae with slender cell processes perpendicular to the tra
Externí odkaz:
https://doaj.org/article/7d8c2b39cd454626b0f95c11b79de3de