Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Taiga Uekusa"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2560 (2022)
The purpose of the present study was to experimentally confirm the thermodynamic correlation between the intrinsic liquid–liquid phase separation (LLPS) concentration (S0LLPS) and crystalline solubility (S0c) of drug-like molecules. Based on the th
Externí odkaz:
https://doaj.org/article/434264bca2f04ce1b34bdab0cc7f2131
Autor:
Taiga Uekusa, Kiyohiko Sugano
Publikováno v:
Molecular Pharmaceutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e0f7cfaf184026f43c6fa34ae6a26f
https://doi.org/10.1021/acs.molpharmaceut.3c00157
https://doi.org/10.1021/acs.molpharmaceut.3c00157
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 168
The purpose of the present study was to investigate the suitability of equilibrium slurry pH (pHeq) as a surrogate of solid surface pH during drug dissolution (pH0). A comprehensive calculation scheme for pHeq and pH0 was formalized based on the prin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883e9680e8a91a458e2a94009fecbb93
https://pubmed.ncbi.nlm.nih.gov/34637897
https://pubmed.ncbi.nlm.nih.gov/34637897
Publikováno v:
Molecular Pharmaceutics. 16:1669-1677
Supersaturable active pharmaceutical ingredients (sAPI), such as salts, cocrystals, and amorphous solids, can form supersaturated solutions after dissolving in the gastrointestinal fluids. However, there are cases in which supersaturation is not obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0082b62bf916fed64a7b0c239249f6e
https://doi.org/10.1021/acs.molpharmaceut.9b00006
https://doi.org/10.1021/acs.molpharmaceut.9b00006
Publikováno v:
Molecular pharmaceutics. 17(10)
The purpose of the present study was to investigate the effect of the coformer difference on particle surface solution-mediated phase transformation (PS-SMPT) during cocrystal particle dissolution in aqueous media in the absence and presence of polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f0571a50383dfbe739793c927cecca
https://pubmed.ncbi.nlm.nih.gov/32870691
https://pubmed.ncbi.nlm.nih.gov/32870691
Autor:
Kiyohiko Sugano, Taiga Uekusa
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 161:45-50
The purpose of the present study was to investigate the precipitation of a drug on the particle surface of its salt in biorelevant media. Pioglitazone (PIO, weak base, pKa = 5.8) was used as a model drug. The crystal particles of PIO hydrochloride (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de1c70c43aed48377c51225a4bcc0e0
https://doi.org/10.1016/j.jpba.2018.08.028
https://doi.org/10.1016/j.jpba.2018.08.028
Publikováno v:
Journal of Drug Delivery Science and Technology. 56:101566
In this study, we investigated solution-mediated phase transformation (SMPT) during cocrystal particle dissolution. When the solubility of a cocrystal is higher than that of the free form, the concentration of the free form can be supersaturated at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9cf75f3fd0f4a2bd0a5cda6b86f1c71
https://doi.org/10.1016/j.jddst.2020.101566
https://doi.org/10.1016/j.jddst.2020.101566
Publikováno v:
Journal of Drug Delivery Science and Technology. 55:101492
The purpose of the present study was to investigate the effect of buffer capacity (β) on the dissolution, supersaturation, and precipitation (DSP) profiles of a salt form drug. The DSP of pioglitazone HCl (PIO–HCl, pKa = 5.8, intrinsic solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2bbc1c2c72c6e1a22442aaa5994fd8
https://doi.org/10.1016/j.jddst.2019.101492
https://doi.org/10.1016/j.jddst.2019.101492