Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Taichiro Nishikawa"'
Autor:
Tomohiro Soda, Yasuyuki Gen, Kei Terasaki, Naoto Iwai, Tomoko Kitaichi, Osamu Dohi, Hiroyoshi Taketani, Yuya Seko, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh, Kohichiroh Yasui
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Signet-ring cell carcinoma (SRCC) is a unique subtype of gastric cancer that is impaired for cell–cell adhesion. The pathogenesis of SRCC remains unclear. Here, we show that expression of kinesin-associated protein 3 (KAP3), a cargo adapto
Externí odkaz:
https://doaj.org/article/bec98801d67c4a62b99b65ef2b2789ea
Autor:
Keiichiro Okuda, Atsushi Umemura, Seita Kataoka, Kota Yano, Aya Takahashi, Shinya Okishio, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hayato Nakagawa, Yu Liu, Yasuhide Mitsumoto, Yoshihiro Kanbara, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine. L-asparaginase (ASNase) converts
Externí odkaz:
https://doaj.org/article/51f700cc3d644c598a99a775e3d1e527
Autor:
Seita Kataoka, Atsushi Umemura, Keiichiro Okuda, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshihiro Kanbara, Jack L. Arbiser, Toshihide Shima, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13354 (2021)
Chronic liver injury may result in hepatic fibrosis, which can progress to cirrhosis and eventually liver failure. There are no drugs that are specifically approved for treating hepatic fibrosis. The natural product honokiol (HNK), a bioactive compou
Externí odkaz:
https://doaj.org/article/6d1de62a58cf4b15a1d6e4a2f0dbe52e
Autor:
Keiichiro Okuda, Atsushi Umemura, Shiori Umemura, Seita Kataoka, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshihiro Kanbara, Jack L. Arbiser, Toshihide Shima, Takeshi Okanoue, Michael Karin, Yoshito Itoh
Publikováno v:
Cancers, Vol 13, Iss 7, p 1515 (2021)
Non-alcoholic steatohepatitis (NASH) has become a serious public health problem associated with metabolic syndrome. The mechanisms by which NASH induces hepatocellular carcinoma (HCC) remain unknown. There are no approved drugs for treating NASH or p
Externí odkaz:
https://doaj.org/article/874412f360624bfabc9ce804bbddba94
Autor:
Aya Takahashi, Michihisa Moriguchi, Yuya Seko, Toshihide Shima, Yasuhide Mitsumoto, Hidetaka Takashima, Hiroyuki Kimura, Hideki Fujii, Hiroki Ishikawa, Takaharu Yo, Hiroshi Ishiba, Atsuhiro Morita, Masayasu Jo, Yasuyuki Nagao, Masahiro Arai, Tasuku Hara, Akira Okajima, Akira Muramatsu, Naomi Yoshinami, Tomoki Nakajima, Hironori Mitsuyoshi, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Cancers, Vol 12, Iss 3, p 754 (2020)
We investigated the association between early tumor shrinkage (ETS) and treatment outcome in patients with hepatocellular carcinoma treated with lenvatinib (LEN). A retrospective analysis was performed in 104 patients. ETS was defined as tumor shrink
Externí odkaz:
https://doaj.org/article/ea6fa20494194994b08b058f8d1c5545
Autor:
Kota Yano, Yuya Seko, Aya Takahashi, Shinya Okishio, Seita Kataoka, Masashi Takemura, Keiichiroh Okuda, Naoki Mizuno, Hiroyoshi Taketani, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Diagnostics, Vol 10, Iss 2, p 86 (2020)
Sodium-glucose cotransporter-2 inhibitors (SGLT2I) have been reported to have renal-protective effects in patients with type 2 diabetes (T2DM). This a retrospective study aimed to evaluate the effect of SGLT2I on renal function in patients with nonal
Externí odkaz:
https://doaj.org/article/8ccd804d94b740b8aa4414baa3c68d51
Autor:
Kazuki Kodo, Satoru Sugimoto, Hisakazu Nakajima, Jun Mori, Ikuyo Itoh, Shota Fukuhara, Keiichi Shigehara, Taichiro Nishikawa, Kitaro Kosaka, Hajime Hosoi
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173661 (2017)
Erythropoietin (EPO), clinically used as a hematopoietic drug, has received much attention due to its nonhematopoietic effects. EPO reportedly has beneficial effects on obesity and diabetes mellitus. We investigated whether interscapular brown adipos
Externí odkaz:
https://doaj.org/article/e0684de7e0fe47e9807a3ba831586cf7
Autor:
Masashi Takemura, Hiroyoshi Taketani, Aya Takahashi, Taichiro Nishikawa, Keiichiroh Okuda, Yoshito Itoh, Yuya Seko, Shinya Okishio, Atsushi Umemura, Seita Kataoka, Kanji Yamaguchi, Michihisa Moriguchi, Naoki Mizuno
Publikováno v:
Internal Medicine
Objective Although most patients who obtain a sustained virological response (SVR) show an improved liver function, some show decreased platelet counts after the eradication of hepatitis C virus (HCV). The aim of this retrospective study was to clari
Autor:
Yu Liu, Kota Yano, Taichiro Nishikawa, Yasuhide Mitsumoto, Yoshihiro Kanbara, Hayato Nakagawa, Atsushi Umemura, Seita Kataoka, Shinya Okishio, Toshihide Shima, Michihisa Moriguchi, Kanji Yamaguchi, Yoshito Itoh, Yuya Seko, Keiichiro Okuda, Takeshi Okanoue, Aya Takahashi, Hiroyoshi Taketani
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine. L-asparaginase (ASNase) converts
Autor:
Hisakazu Nakajima, Shin-ichi Horike, Kanji Yamaguchi, Yoshito Itoh, Kohichiroh Yasui, Michihisa Moriguchi, Wataru Aoi, Kazuki Kodo, Atsushi Umemura, Makiko Meguro-Horike, Satoru Sugimoto, Hiroyoshi Taketani, Taichiro Nishikawa, Yuya Seko, Hiroshi Ishiba
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12:1473-1492
Background and aims Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome, and its progression is associated with aging-associated impairment in metabolic homeostasis. Recently, energy metabolism in adipose tissue