Chemogenetic silencing of the subiculum blocks acute chronic temporal lobe epilepsy

Autor: Jianbang Lin, Jing Liu, Qi Zhang, Taian Liu, Zexuan Hong, Yi Lu, Cheng Zhong, Zhonghua Lu, Yuantao Li, Yu Hu

Publikováno v: Molecular Brain, Vol 17, Iss 1, Pp 1-11 (2024)

Abstract Temporal lobe epilepsy (TLE) is the most common form of medically-intractable epilepsy. Subicular hyperexcitability is frequently observed with TLE, presumably caused by impaired inhibition of local excitatory neurons. Here, we evaluated the

Externí odkaz: https://doaj.org/article/0cad844d461341f0a6f45915b5d96f24

Protocol for chemogenetic activation of basal ganglia D1-MSNs and behavioral assessments in a primate Parkinson’s disease model

Autor: Yefei Chen, Zexuan Hong, Ting Yan, Yuyuan Zhu, Jianbang Lin, Taian Liu, Ming Guo, Mengqi Li, Shijing Feng, Ronghui Li, Jianqing Zhang, Siyang Chen, Yi Yang, Yuantao Li, Zhonghua Lu

Publikováno v: STAR Protocols, Vol 5, Iss 4, Pp 103470- (2024)

Summary: A circuit-based gene therapy strategy for Parkinson’s disease (PD) has been shown to significantly reverse core symptoms in both murine and primate PD models. Here, we present a comprehensive workflow to specifically manipulate dopamine re

Externí odkaz: https://doaj.org/article/1d22997db04f45b592380665f31feae6

Fragmentation of China’s landscape by roads and urban areas

Autor: Ryan M Boynton, Feng-Min Li, Heidi Schott, Fraser Shilling, James H. Thorne, Alison M. Berry, Taian Li

Publikováno v: Li, Taian; Shilling, Fraser; Thorne, James H.; Li, Fengmin; Schott, Heidi; Boynton, Ryan; et al.(2010). Fragmentation of China’s landscape by roads and urban areas. Institute of Transportation Studies. UC Davis: Institute of Transportation Studies (UCD). Retrieved from: http://www.escholarship.org/uc/item/3c2527hk

China’s major paved road-ways (national roads, provincial roads, and county roads), railways and urban development are rapidly expanding. A likely consequence of this fast-paced growth is landscape fragmentation and disruption of ecological flows.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d91c12e8f8eead2353e8acf7e7915fa
http://www.escholarship.org/uc/item/3c2527hk

Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development

Autor: Zeyao Zhu, Yun Liu, Wen Xu, Taian Liu, Yuxin Xie, Kathy W. Y. Sham, Ou Sha, Christopher H. K. Cheng

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Dgcr8 is involved in the biogenesis of canonical miRNAs to process pri-miRNA into pre-miRNA. Previous studies have provided evidence that Dgcr8 plays an essential role in different biological processes. However, the function of maternal and zygotic D

Externí odkaz: https://doaj.org/article/e999c69bbf14484295ff0fd3565370ed

An arbitrary shape clustering algorithm over variable density data streams

Autor: Na Su, Jimin Liu, Changqing Yan, Taian Liu, Xinjun An

Publikováno v: Journal of Algorithms & Computational Technology, Vol 11 (2017)

This paper proposes VDStream, a new effective method, to discover arbitrary shape clusters over variable density data streams. The algorithm can reduce the influence of history data and effectively eliminate the interference of noise data. When the d

Externí odkaz: https://doaj.org/article/a539390fae3846ed834fdf0535a7760b