Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Tai-Guang Jin"'
2
Discovery of potent and selective CDK8 inhibitors through FBDD approach
Autor: Rui Niu, Chengang Zhou, Zheng Zhou, Lisha Wang, Alexander V. Mayweg, Zhiheng Xu, Tai-Guang Jin, Min Jiang, Song Yang, Xingchun Han
Publikováno v: Bioorganicmedicinal chemistry letters. 27(18)
A fragment library screen was carried out to identify starting points for novel CDK8 inhibitors. Optimization of a fragment hit guided by co-crystal structures led to identification of a novel series of potent CDK8 inhibitors which are highly ligand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc588cdd5a329d650785bf7b96e3b81
https://pubmed.ncbi.nlm.nih.gov/28802632
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5
A Double Hit to Kill Tumor and Endothelial Cells by TRAIL and Antiangiogenic 3TSR
Autor: Jack Lawler, Xuefeng Zhang, Nordine Benhaga, Sareh Parangi, Min Ye, Robin Humphreys, Roya Khosravi-Far, Keli Song, Tai-Guang Jin, Mark Duquette, Bin Ren
Publikováno v: Cancer Research. 69:3856-3865
As tumor development relies on a coordination of angiogenesis and tumor growth, an efficient antitumor strategy should target both the tumor and its associated vessels. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8713260109b830d17f1d450a21b9540f
https://doi.org/10.1158/0008-5472.can-08-2940
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6
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3
Autor: Philimon Gona, Tai-Guang Jin, Kenneth Ndebele, Roya Khosravi-Far, Nordine Benhaga, Mauro Degli-Esposti, Anas Chalah
Publikováno v: Apoptosis. 13:845-856
Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) initiate pathways of cell death in which caspase activation is mediated either directly (without mitochondrial amplification), or indirectly via the release of apoptogenic factors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d25338c5f1b890820b28e1c2769f3dc
https://doi.org/10.1007/s10495-008-0219-4
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7
Fas-associated Protein with Death Domain (FADD)-independent Recruitment of c-FLIPL to Death Receptor 5
Autor: Brian K. Kay, Mehrdad Mohseni, Karon Abe, Keli Song, Nordine Benhaga, Ferry Sandra, Alexei Kurakin, Roya Khosravi-Far, Tai-Guang Jin
Publikováno v: Journal of Biological Chemistry. 279:55594-55601
Here we show a novel mechanism by which FLICE-like inhibitory protein (c-FLIP) regulates apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and one of its receptors, DR5. c-FLIP is a critical regulator of the T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72107853fe4ac311ee71f46a787e3d9
https://doi.org/10.1074/jbc.m401056200
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8
Persistent c-FLIP(L) Expression Is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand–Mediated Apoptosis in Prostate Cancer
Autor: Roya Khosravi-Far, Xiaoping Zhang, Tai-Guang Jin, Hongmei Yang, William C. DeWolf, Aria F. Olumi
Publikováno v: Cancer Research. 64:7086-7091
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in a variety of tumorigenic and transformed cell lines but not in many normal cells. Hence, TRAIL has the potential to be an ideal cancer therapeutic a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cff5db77774ea098e16004bd154cde
https://doi.org/10.1158/0008-5472.can-04-1498
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9
RA-GEF-1, a Guanine Nucleotide Exchange Factor for Rap1, Is Activated by Translocation Induced by Association with Rap1·GTP and Enhances Rap1-dependent B-Raf Activation
Autor: Tohru Kataoka, Xianlong Gao, Takaya Satoh, Chang-Deng Hu, Yanhong Liao, Tai-Guang Jin
Publikováno v: Journal of Biological Chemistry. 276:28478-28483
We previously identified RA-GEF-1, a novel guanine nucleotide exchange factor (GEF) for Rap1 with the ability to associate with Rap1.GTP at its Ras/Rap1-associating (RA) domain. Because it possesses a PSD-95/DlgA/ZO-1 (PDZ) domain, it was also named
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b0d91cdffed2288ce37375bb4618c0
https://doi.org/10.1074/jbc.m101737200
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10
RA-GEF, a Novel Rap1A Guanine Nucleotide Exchange Factor Containing a Ras/Rap1A-associating Domain, Is Conserved between Nematode and Humans
Autor: Masahiro Goshima, Yanhong Liao, Tomoyo Okada, Yasuhiro Watari, Tohru Kataoka, Yuriko Yamawaki-Kataoka, Xianlong Gao, Mitsushige Shibatohge, Chang-Deng Hu, Ken-ichi Kariya, Tai-Guang Jin
Publikováno v: Journal of Biological Chemistry. 274:37815-37820
A yeast two-hybrid screening for Ras-binding proteins in nematode Caenorhabditis elegans has identified a guanine nucleotide exchange factor (GEF) containing a Ras/Rap1A-associating (RA) domain, termed Ce-RA-GEF. Both Ce-RA-GEF and its human counterp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7c7633ecd60cf48a7297ca439eaa22
https://doi.org/10.1074/jbc.274.53.37815
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