Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Tai Shun Lin"'
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background and aims The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) in hepatocellular carcinoma (HCC) patients is increasing, yet its association with postoperative complications of HCC remains unclear. The aim
Externí odkaz:
https://doaj.org/article/acbcc576fcb345bb839d3fae632367b6
Publikováno v:
Medicine. 102:e33062
Autor:
Ke-Gong, Xiong, Kun-Yu, Ke, Li-Fang, Chen, Jin-Feng, Kong, Tai-Shun, Lin, Qing-Biao, Lin, Su, Lin, Yue-Yong, Zhu
Publikováno v:
Hepatobiliary & Pancreatic Diseases International.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is recently proposed an entity by a group of international experts. However, the impact of MAFLD on the prognosis of patients with hepatocellular carcinoma (HCC) is not clear. The aim of th
Autor:
Yung-Chi Cheng, Alan C. Sartorelli, Diane E. Mozdziesz, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Elizabeth A. Gullen, Mei-Zhen Luo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2145-2148
Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucleosides have been synthesized and evaluated for biological activity. (-)-(2S,4S)-1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed significant activity against H
Autor:
Mao-Chin Liu, Mei-Zhen Luo, Diane E. Mozdziesz, Tai-Shun Lin, Ginger E., null Dutschman, Yung-Chi Cheng, Alan C. Sartorelli
Publikováno v:
Nucleosides and Nucleotides. 18:55-72
2'-Deoxy-2'-methylene-6-azauridine (5) and 2'-deoxy-2'-methylene-6-azacytidine (8) have been synthesized via a multi-step procedure from 6-azauridine. 2'-Deoxy-2'-methylene-5-azacytidine (14a) and 2'-deoxy-2'-methylene-3-deazaguanosine (19a) and thei
Publikováno v:
Journal of Medicinal Chemistry. 39:2586-2593
A series of 3- and 5-alkylamino derivatives, as well as other structurally modified analogues of pyridine-2-carboxaldehyde thiosemicarbazone, have been synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vi
Autor:
Ju-Liang Zhu, Tai-Shun Lin, Mao-Chin Liu, Ginger E. Dutschman, Yung-Chi Cheng, Yimei Zhu, Mei-Zhen Luo
Publikováno v:
Nucleosides and Nucleotides. 14:1759-1783
Various 2′,3′-dideoxy-L-nucleoside analogues, 6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl) purine (19), 2-chloro-6-amino-9-(2,3-dideoxy-β-L-ribofuranosyl)-purine (20), 2-chloro-6-amino-9-(2,3-dideoxy-4-thio-β-L-ribofuranosyl) purine (21), 2,6-dia
Publikováno v:
Journal of Medicinal Chemistry. 38:4234-4243
Various substituted isoquinoline-1-carboxaldehyde thiosemicarbazones (12 compounds) have been synthesized and evaluated for antineoplastic activity in mice bearing the L1210 leukemia. Condensation of 4-bromo-1-methylisoquinoline (4) with ammonium hyd
Autor:
Chung K. Chu, Marina K. Kukhanova, Tai-Shun Lin, Shwu-Huey Liu, Dmitry Ju. Mozzherin, Yung-Chi Cheng
Publikováno v:
Journal of Biological Chemistry. 270:23055-23059
5′-Triphosphates of β-D and β-L-enantiomers of 2′,3′-dideoxycytidine (ddC), 2′,3′-dideoxy-5-fluorocytidine (FddC), 1,3-dioxolane-cytidine (OddC), and 1,3-dioxolane-5-fluorocytidine (FOddC) were evaluated as inhibitors and substrates for h
Autor:
Mao-Chin Liu, Yong-Lian Zhu, Ginger E. Dutschman, S. Balakrishna Pai, Tai-Shun Lin, Mei-Zhen Luo, Yung-Chi Cheng, Mao-Mi Li, Xin Guo
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:619-625
The pharmacokinetics and toxicology of 2′,3′-dideoxy-β-L-5-fluorocytidine (β-L-FddC) and 2′,3′-dideoxy-β-L-cytidine (β-L-ddC) in mice was investigated. In addition, 2′,3′-dideoxy-β-L-5-azacytidine (β-L-5-aza-ddC) and its α-L-anomer