Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tai Qin Huang"'
Autor:
Francis J. Miller, Igor Nepliouev, Elizabeth R. Hauser, Tai-Qin Huang, Neil J. Freedman, Lisheng Zhang, Leigh Brian, Kamie P. Snow, Brandon M. Schickling, Jonathan A. Stiber, Jiao-Hui Wu
Publikováno v:
Cardiovasc Res
Aims The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation and pro-inflammatory signaling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis. Methods and results SM22-Cre+/Dbnflox/flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b1740f44c3569381dd8103782bb6b4
https://doi.org/10.1093/cvr/cvab156
https://doi.org/10.1093/cvr/cvab156
Autor:
Asima Chakraborty, Daniel A Pasek, Tai-Qin Huang, Angela C Gomez, Naohiro Yamaguchi, Mark E Anderson, Gerhard Meissner
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104338 (2014)
In cardiac muscle, the release of calcium ions from the sarcoplasmic reticulum through ryanodine receptor ion channels (RyR2s) leads to muscle contraction. RyR2 is negatively regulated by calmodulin (CaM) and by phosphorylation of Ca2+/CaM-dependent
Externí odkaz:
https://doaj.org/article/2c7ef560bb6e49e5aa3ee8fb6c33ffea
Publikováno v:
Journal of Receptor, Ligand & Channel Research. 2015, Vol. 8, p43-51. 9p.
Autor:
Tai Qin Huang, Clara Franzini-Armstrong, Gerhard Meissner, Manuela Lavorato, Stefano Perni, Venkat Ramesh Iyer
Publikováno v:
Journal of Muscle Research and Cell Motility. 36:205-214
In cardiac muscle, calmodulin (CaM) regulates the activity of several membrane proteins involved in Ca2+ homeostasis (CaV1.2; RyR2, SERCA2, PMCA). Three engineered amino acid substitutions in the CaM binding site of the cardiac ryanodine receptor (Ry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009a7f231c96670428e131a2ab1243c5
https://doi.org/10.1007/s10974-015-9405-5
https://doi.org/10.1007/s10974-015-9405-5
Autor:
Sudha K. Shenoy, Leigh Brian, Jonathan A. Stiber, Lisheng Zhang, Jiao-Hui Wu, Nathan P. Rudemiller, Virginia Wertman, Neil J. Freedman, Tai-Qin Huang, Francis J. Miller, Timothy J. McMahon, Zhu-Shan Zhang, Steven D. Crowley, Igor Nepliouev
Publikováno v:
Cardiovascular research. 114(13)
AIMS: The actin-binding protein Drebrin is up-regulated in response to arterial injury and reduces smooth muscle cell (SMC) migration and proliferation through its interaction with the actin cytoskeleton. We, therefore, tested the hypothesis that SMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c350a50aa026383b2d62495521c866ed
https://pubmed.ncbi.nlm.nih.gov/30107397
https://pubmed.ncbi.nlm.nih.gov/30107397
Autor:
Paul B. Rosenberg, Sai-Hong Ignatius Ou, Igor Nepliouev, Jonathan A. Stiber, Hengtao Zhang, Zhu-Shan Zhang, Adam S. Barnett, Tai-Qin Huang
Publikováno v:
Cardio-Oncology. 3
Sinus bradycardia is frequently observed in patients treated with crizotinib, a receptor tyrosine kinase inhibitor used for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We investigated whether crizo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98d3f6d44cab9f845fa70306ac0ce5c
https://doi.org/10.1186/s40959-017-0020-z
https://doi.org/10.1186/s40959-017-0020-z
Autor:
Angela C. Gomez, Daniel A. Pasek, Naohiro Yamaguchi, Gerhard Meissner, Asima Chakraborty, Le Xu, Tai Qin Huang
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 305:H86-H94
The cardiac ryanodine receptor (RyR2) is inhibited by calmodulin (CaM) and S100A1. Simultaneous substitution of three amino acid residues (W3587A, L3591D, F3603A; RyR2ADA) in the CaM binding domain of RyR2 results in loss of CaM inhibition at submicr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20240ecef269891eb26ecdf9481d0811
https://doi.org/10.1152/ajpheart.00144.2013
https://doi.org/10.1152/ajpheart.00144.2013
Publikováno v:
Journal of receptor, ligand and channel research
Tai-Qin Huang,* Min-Xu Zou,* Daniel A Pasek, Gerhard MeissnerDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA *These authors contributed equally to this work Abstract: Simultaneous substitution of three am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bbea2f09a5e909a3a0dc4ba3922885
https://www.dovepress.com/mtor-signaling-in-mice-with-dysfunctional-cardiac-ryanodine-receptor-i-peer-reviewed-article-JRLCR
https://www.dovepress.com/mtor-signaling-in-mice-with-dysfunctional-cardiac-ryanodine-receptor-i-peer-reviewed-article-JRLCR
Publikováno v:
International Journal of Radiation Biology. 81:781-792
Heat shock protein 70 (HSP70) is one of the most inducible proteins to play a cytoprotective role under stressful conditions. Previously we generated hsp70.1-deficient mice to elucidate the in vivo function of HSP70 in detail. The renal tissues and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e131fac2db1ea2035a8d7a9697d0af
https://doi.org/10.1080/09553000500500188
https://doi.org/10.1080/09553000500500188
Publikováno v:
International Journal of Radiation Biology. 81:861-867
Although radiofrequency (RF) radiation is not considered mutagenic, it has been suggested as a promoter of tumorigenesis. To study if RF radiation has a tumor promoting effect, we exposed mice with skin tumorigenesis initiated by 7,12-dimethybenz[a]a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac733ea131be52983c7d7cb5e6bd77da
https://doi.org/10.1080/09553000600568093
https://doi.org/10.1080/09553000600568093