The conformation of the nSrc specificity-determining loop in the Src SH3 domain is modulated by a WX conserved sequence motif found in SH3 domains.

Autor: Longshore-Neate, Frederick, Ceravolo, Caroline, Masuga, Cole, Tahti, Elise F., Blount, Jadon M., Smith, Sarah N., Amacher, Jeanine F.

Publikováno v: Frontiers in Molecular Biosciences; 2024, p1-13, 13p

Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.

Autor: Tahti EF; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Blount JM; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Jackson SN; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Gao M; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Gill NP; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Smith SN; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Pederson NJ; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Rumph SN; Department of Biochemistry, Bowdoin College, Brunswick, ME, USA., Struyvenberg SA; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Mackley IGP; Department of Chemistry, Western Washington University, Bellingham, WA, USA., Madden DR; Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Amacher JF; Department of Chemistry, Western Washington University, Bellingham, WA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 10. Date of Electronic Publication: 2023 Jan 10.