Protein Biomarkers of Adverse Clinical Features and Events in Sarcomeric Hypertrophic Cardiomyopathy.

Autor: Tahir UA; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., S.D., E.A., G.T., R.E.G.)., Kolm P; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (P.K., S.K.P., H.W., S.N.)., Kwong RY; Departments of Medicine, Radiology, and Pathology, Brigham and Women's Hospital, Boston, MA (R.Y.K., M.J.-H., P.J., C.Y.H.)., Desai MY; Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (M.Y.D)., Dolman SF; MedStar Heart and Vascular Institute, Washington, DC (S.F.D., J.H.Z.-P., W.S.W.)., Deng S; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., S.D., E.A., G.T., R.E.G.)., Appelbaum E; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., S.D., E.A., G.T., R.E.G.)., Desvigne-Nickens P; National Heart, Lung, and Blood Institute, Bethesda, MD (P.D.-N., D.-Y.K.)., DiMarco JP; Cardiovascular Division, University of Virginia Health System, Charlottesville (J.P.D., C.M.K.)., Tiwari G; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., S.D., E.A., G.T., R.E.G.)., Friedrich MG; McGill University, Montreal, QC, Canada (M.G.F.)., Zelaya-Portillo JH; MedStar Heart and Vascular Institute, Washington, DC (S.F.D., J.H.Z.-P., W.S.W.)., Jerosch-Herold M; Departments of Medicine, Radiology, and Pathology, Brigham and Women's Hospital, Boston, MA (R.Y.K., M.J.-H., P.J., C.Y.H.)., Kim DY; National Heart, Lung, and Blood Institute, Bethesda, MD (P.D.-N., D.-Y.K.)., Maron MS; Lahey Hospital and Medical Center, Burlington, MA (M.S.M.)., Piechnik SK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (P.K., S.K.P., H.W., S.N.)., Schulz-Menger J; Charité Experimental Clinical Research Center and Helios Clinics Berlin-Buch, Germany (J.S.-M.)., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (P.K., S.K.P., H.W., S.N.)., Weintraub WS; MedStar Heart and Vascular Institute, Washington, DC (S.F.D., J.H.Z.-P., W.S.W.)., Neubauer S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom (P.K., S.K.P., H.W., S.N.)., Kramer CM; Cardiovascular Division, University of Virginia Health System, Charlottesville (J.P.D., C.M.K.)., Jarolim P; Departments of Medicine, Radiology, and Pathology, Brigham and Women's Hospital, Boston, MA (R.Y.K., M.J.-H., P.J., C.Y.H.)., Gerszten RE; Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (U.A.T., S.D., E.A., G.T., R.E.G.)., Ho CY; Departments of Medicine, Radiology, and Pathology, Brigham and Women's Hospital, Boston, MA (R.Y.K., M.J.-H., P.J., C.Y.H.).

Publikováno v: Circulation. Heart failure [Circ Heart Fail] 2024 Nov 05, pp. e011707. Date of Electronic Publication: 2024 Nov 05.

Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans.

Autor: Tahir UA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Barber JL; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Cruz DE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Kars ME; Mount Sinai School of Medicine, New York, New York, USA., Deng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Tuftin B; Mount Sinai School of Medicine, New York, New York, USA., Gillman MG; University of North Carolina School of Medicine, Raleigh, North Carolina, USA., Benson MD; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Robbins JM; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Chen ZZ; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Rao P; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Katz DH; Stanford School of Medicine, Palo Alto, California, USA., Farrell L; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Sofer T; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Hall ME; University of Mississippi Medical Center, Jackson, Mississippi, USA., Ekunwe L; University of Mississippi Medical Center, Jackson, Mississippi, USA., Tracy RP; Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Durda P; Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, California, USA., Liu Y; Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA., Johnson WC; Department of Biostatistics, University of Washington, Seattle, Washington, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, California, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, California, USA., Manichaikul AW; Center for Public Health Genomics and.; Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA., Jain D; University of Washington, Seattle, Washington., Wang TJ; Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, USA., Reiner AP; University of Washington, Seattle, Washington., Natarajan P; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Itan Y; University of North Carolina School of Medicine, Raleigh, North Carolina, USA., Rich SS; Center for Public Health Genomics and., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Torrance, California, USA., Wilson JG; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Raffield LM; University of North Carolina School of Medicine, Raleigh, North Carolina, USA., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Sep 24; Vol. 134 (21). Date of Electronic Publication: 2024 Sep 24.

Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension.

Autor: Rao P; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Keyes MJ; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Mi MY; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Barber JL; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia., Tahir UA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Deng S; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Clish CB; Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge., Shen D; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Farrell LA; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Wilson JG; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Gao Y; Department of Data Sciences, University of Mississippi Medical Center, Jackson., Yimer WK; Department of Data Sciences, University of Mississippi Medical Center, Jackson., Ekunwe L; Jackson Heart Study Field Center, University of Mississippi Medical Center, Jackson., Hall ME; Department of Medicine, Division of Cardiology, University of Mississippi Medical Center, Jackson., Muntner PM; Department of Epidemiology, University of Alabama at Birmingham, Birmingham., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance., Tracy RP; Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles Medical Center, Torrance., Xanthakis V; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts., Vasan RS; Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts.; Department of Medicine, Boston University School of Medicine, Boston, Massachusetts., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana., Sarzynski MA; Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge., Robbins JM; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.; CardioVascular Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Publikováno v: JAMA cardiology [JAMA Cardiol] 2024 Aug 01; Vol. 9 (8), pp. 713-722.

Lac-Phe mediates the effects of metformin on food intake and body weight.

Autor: Xiao S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Li VL; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA., Lyu X; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA., Chen X; Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Wei W; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Abbasi F; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Knowles JW; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA., Tung AS; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Deng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Tiwari G; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Shi X; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Zheng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Farrell L; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Chen ZZ; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Wood AC; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Clish CB; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tahir UA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Benson MD; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Long JZ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. jzlong@stanford.edu.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA. jzlong@stanford.edu.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. jzlong@stanford.edu.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA. jzlong@stanford.edu.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. jzlong@stanford.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Apr; Vol. 6 (4), pp. 659-669. Date of Electronic Publication: 2024 Mar 18.

Lac-Phe mediates the anti-obesity effect of metformin.

Autor: Xiao S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Li VL; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Chemistry, Stanford University, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA., Lyu X; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA., Chen X; Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Wei W; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA., Abbasi F; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Knowles JW; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA., Deng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Tiwari G; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Shi X; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Zheng S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Farrell L; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Chen ZZ; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Goodarzi MO; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA., Wood AC; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX USA., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Clish CB; Broad Institute of Harvard and MIT, Cambridge, MA., Tahir UA; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA.; Broad Institute of Harvard and MIT, Cambridge, MA., Benson MD; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA., Long JZ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.; Sarafan ChEM-H, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Human Performance Alliance, Stanford University, Stanford, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 04. Date of Electronic Publication: 2023 Nov 04.