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Strand 1A variant in neuroserpin shows increased aggregation and no loss of inhibition: Implication in ameliorating polymerization to retain activity

Autor: Shoyab Ansari, Shahzaib Ahamad, Abdul Burhan Khan, Sana Fatima, Tahif Ahmad, Yasmeen Khan, Dinesh Gupta, Mohamad Aman Jairajpuri

Publikováno v: Bioscience reports.

Neuroserpin (NS) is predominantly expressed in the brain and is the primary inhibitor of tissue plasminogen activator (tPA). NS variants are associated with the neurogenerative disease termed familial encephalopathy with neuroserpin inclusion bodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbc8d6088a565e92f82671e443bb5a5
https://pubmed.ncbi.nlm.nih.gov/36408789

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