Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tahel, Ronel"'
Autor:
Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106937- (2023)
Summary: T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of indiv
Externí odkaz:
https://doaj.org/article/a3d7eacf94e249aeb9cbbd5c5378f753
Autor:
Tahel Ronel, Matthew Harries, Kate Wicks, Theres Oakes, Helen Singleton, Rebecca Dearman, Gavin Maxwell, Benny Chain
Publikováno v:
eLife, Vol 10 (2021)
Diphenylcyclopropenone (DPC) is an organic chemical hapten which induces allergic contact dermatitis and is used in the treatment of warts, melanoma, and alopecia areata. This therapeutic setting therefore provided an opportunity to study T cell rece
Externí odkaz:
https://doaj.org/article/34a29ae1bbed42fa8f0805557632c0c1
Autor:
Ann-Marie Baker, Gayathri Nageswaran, Pablo Nenclares, Tahel Ronel, Kane Smith, Christopher Kimberley, Miangela M Lacle, Shree Bhide, Kevin J Harrington, Alan Melcher, Manuel Rodriguez-Justo, Benny Chain, Trevor A Graham
Genomic analysis of the T-cell receptor (TCR) reveals the strength, breadth and clonal dynamics of the adaptive immune response to pathogens or cancer. The diversity of the TCR repertoire, however, means that sequencing is technically challenging, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2249478ddad1820a2ad622b86deb541a
https://doi.org/10.1101/2023.04.24.538037
https://doi.org/10.1101/2023.04.24.538037
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Katja Steiger, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland Schmid, Jens Siveke, Michael Quante, Trevor Graham
Locally advanced oesophageal adenocarcinoma (EAC) remains difficult to treat because of common resistance to neoadjuvant therapy and high recurrence rates. The ecological and evolutionary dynamics responsible for treatment failure are incompletely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23626ec121eaf552ab7c2479aaea43d5
https://doi.org/10.21203/rs.3.rs-2738048/v1
https://doi.org/10.21203/rs.3.rs-2738048/v1
We analyzed the dynamics of the earliest T cell response to SARS-COV-2. A wave of TCRs strongly but transiently expand during infection, frequently peaking the same week as the first positive PCR test. These expanding TCR CDR3s were enriched for sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1576a02987fde72262d7ce8c385b675
https://doi.org/10.1101/2022.11.08.515436
https://doi.org/10.1101/2022.11.08.515436
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland M. Schmid, Jens T. Siveke, Michael Quante, Trevor A. Graham
Publikováno v:
Cancer Research. 83:4539-4539
Introduction: Locally advanced esophageal adenocarcinoma (EAC) remains difficult to treat, and resistance is common. The ecological and evolutionary dynamics responsible for treatment failure are incompletely understood. Aim & Methods: We performed a
Abstract 5934: Tracking T cell clonal dynamics across time and space in metastatic colorectal cancer
Autor:
Ann-Marie Baker, Alison Berner, Tahel Ronel, Nick Trahearn, Barbara Bravi, John Bridgewater, Benny Chain, Trevor A. Graham
Publikováno v:
Cancer Research. 83:5934-5934
Here we tracked T cell dynamics in 15 metastatic colorectal cancer (mCRC) patients who had multiple resections (median: 3, range: 2-7) over a period of >7 years (median: 10 years, range: 7-16 years), using a novel T cell receptor sequencing (TCRseq)
Autor:
Aneesh Chandran, Joshua Rosenheim, Gayathri Nageswaran, Leo Swadling, Gabriele Pollara, Rishi K. Gupta, Alice R. Burton, José Afonso Guerra-Assunção, Annemarie Woolston, Tahel Ronel, Corinna Pade, Joseph M. Gibbons, Blanca Sanz-Magallon Duque De Estrada, Marc Robert de Massy, Matthew Whelan, Amanda Semper, Tim Brooks, Daniel M. Altmann, Rosemary J. Boyton, Áine McKnight, Gabriella Captur, Charlotte Manisty, Thomas Alexander Treibel, James C. Moon, Gillian S. Tomlinson, Mala K. Maini, Benjamin M. Chain, Mahdad Noursadeghi
Effective control of SARS-CoV-2 infection on primary exposure may reveal correlates of protective immunity to future variants, but we lack insights into immune responses before or at the time virus is first detected. We use blood transcriptomics, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ed668bb93cbe83a772638e36ecadcc
http://hdl.handle.net/10044/1/96150
http://hdl.handle.net/10044/1/96150