Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Tahar Lakhlifi"'
Autor:
Khadija Zaki, Fatimazahra Fakir, Abdelouahid Sbai, Hamid Maghat, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Current Chemistry Letters, Vol 13, Iss 3, Pp 451-466 (2024)
Protein IDO1 (indoleamine 2,3-dioxygenase) occupies a critical position in the regulation of the immune system and is involved in cancer progression and the development of immune diseases. Being a therapeutic target for such critical diseases, we aim
Externí odkaz:
https://doaj.org/article/76c6be4381ef4d0d9bf7273bcb778c57
Autor:
Soukaina Bouamrane, Ayoub Khaldan, Marwa Alaqarbeh, Abdelouahid Sbai, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine, Hamid Maghat
Publikováno v:
Chemical Physics Impact, Vol 8, Iss , Pp 100502- (2024)
Fungal infections are a growing public health problem worldwide. Despite the availability of several medicines, their efficacy is still constrained by fungal resistance. This research conducted the 2D/3D-QSAR analysis on twenty-nine triazole molecule
Externí odkaz:
https://doaj.org/article/ed52f1aba3dd48468596591a87199319
Autor:
Ayoub Khaldan, Soukaina Bouamrane, Reda El-mernissi, Mohamed Ouabane, Marwa Alaqarbeh, Hamid Maghat, Mohammed Aziz Ajana, Chakib Sekkat, Mohammed Bouachrine, Tahar Lakhlifi, Abdelouahid Sbai
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105656- (2024)
Diabetes mellitus is a chronic and non-infectious metabolic disorder caused by insufficient insulin secretion. This study investigated a set of thirty-one 4-amino-1,2,4-triazole derivatives, experimentally evaluated for their α-glucosidase activity
Externí odkaz:
https://doaj.org/article/bb0a9df2199f4b89a6c426610662e072
Autor:
Soukaina Bouamrane, Ayoub Khaldan, Marwa Alaqarbeh, Abdelouahid Sbai, Mohammed Aziz Ajana, Mohammed Bouachrine, Tahar Lakhlifi, Hamid Maghat
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 3, Pp 105642- (2024)
Fungal infections profoundly affect human health, causing a substantial number of infections and millions of fatalities annually on a global scale. The identification of new drugs targeting this infection is a challenge that is not yet complete. Natu
Externí odkaz:
https://doaj.org/article/e1a1625d98d74b1fa1f7ae5bc2bd83f7
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105376- (2024)
The worldwide prevalence of cancer and its increasing frequency make it a key research area in drug discovery programs. The current research paper describes the development of QSAR models based on the in vitro against topoisomerase II, which identifi
Externí odkaz:
https://doaj.org/article/fefdeb9740c346f9a2e3e5c8b24924ce
Autor:
Fatima EN-NAHLI, Halima HAJJI, Mohamed OUABANE, Mohammed Aziz AJANA, Chakib SEKATTE, Tahar LAKHLIFI, Mohammed BOUACHRINE
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 11, Pp 105262- (2023)
In the present study, a Molecular Docking and in silico ADMET analysis were performed to identify the possible inhibitory effect of 23 molecules, pyrazole and pyrazolines derivatives, on Escherichia coli and to predict the absorption, distribution, m
Externí odkaz:
https://doaj.org/article/0b11fa6a9f0d4071ac3d825007229f4c
Autor:
Mohamed OUABANE, Kamal TABTI, Halima HAJJI, Mhamed ELBOUHI, Ayoub KHALDAN, Khalid ELKAMEL, Abdelouahid SBAI, Mohammed Aziz AJANA, Chakib SEKKATE, Mohammed BOUACHRINE, Tahar LAKHLIFI
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 11, Pp 105207- (2023)
In this study, using both 2D-QSPR and 3D-QSPR approaches, to understand the structure-odor relationship of 78 1–4-pyrazine odorant molecules and to use this knowledge for the design of new food and flavor products. According to our results, the dev
Externí odkaz:
https://doaj.org/article/a852833650f14d338691bee2df8ef16f
Autor:
Khalil EL Khatabi, Ilham Aanouz, Marwa Alaqarbeh, Mohammed Aziz Ajana, Tahar Lakhlifi, Mohammed Bouachrine
Publikováno v:
BioImpacts, Vol 12, Iss 2, Pp 107-113 (2022)
Introduction: The new species of coronaviruses (CoVs), SARS-CoV-2, was reported as responsible for an outbreak of respiratory disease. Scientists and researchers are endeavoring to develop new approaches for the effective treatment against of the COV
Externí odkaz:
https://doaj.org/article/4fe6d890ca174e1bab1fd131bb759f39
Autor:
Halima HAJJI, Fatima En-nahli, Ilham Aanouz, Hanane Zaki, Tahar Lakhlifi, Mohammed Aziz Ajana, Mohammed Bouachrine
Publikováno v:
Orbital: The Electronic Journal of Chemistry, Vol 13, Iss 4, Pp 316-327 (2021)
The purpose of the paper is to discuss the various methods and computational approaches, which are used in computer-aided drug design. For this reason, pyrimidine and azaindole derivatives have been used to study the inhibitory activity of CaMKKII. I
Externí odkaz:
https://doaj.org/article/2de8e061e7034d82ab7c54adcf94206a
Autor:
Samir Chtita, Salah Belaidi, Faizan Abul Qais, Mebarka Ouassaf, Muneerah Mogren AlMogren, Ateyah A. Al-Zahrani, Mohamed Bakhouch, Assia Belhassan, Hanane Zaki, Mohammed Bouachrine, Tahar Lakhlifi
Publikováno v:
Journal of King Saud University: Science, Vol 34, Iss 7, Pp 102226- (2022)
COVID-19 pandemic caused by very severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) agent is an ongoing major global health concern. The disease has caused more than 452 million affected cases and more than 6 million death worldwide. Hence,
Externí odkaz:
https://doaj.org/article/353cf912759042f597a8cde8f8cf9eef