Fibrin drives thromboinflammation and neuropathology in COVID-19.

Autor: Ryu JK; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Yan Z; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Montano M; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Sozmen EG; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Dixit K; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Suryawanshi RK; Gladstone Institute of Virology, San Francisco, CA, USA., Matsui Y; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Helmy E; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Kaushal P; Department of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences (QCBio), University of California Los Angeles, Los Angeles, CA, USA., Makanani SK; Department of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences (QCBio), University of California Los Angeles, Los Angeles, CA, USA., Deerinck TJ; National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California San Diego, La Jolla, CA, USA., Meyer-Franke A; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Rios Coronado PE; Department of Biology, Stanford University, Stanford, CA, USA., Trevino TN; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Shin MG; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Tognatta R; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Liu Y; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Schuck R; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Le L; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Miyajima H; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Mendiola AS; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Arun N; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Guo B; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Taha TY; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Agrawal A; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., MacDonald E; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Aries O; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Yan A; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Weaver O; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Petersen MA; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA., Meza Acevedo R; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Alzamora MDPS; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA., Thomas R; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Traglia M; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Kouznetsova VL; San Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.; CureScience Institute, San Diego, CA, USA., Tsigelny IF; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA.; San Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.; CureScience Institute, San Diego, CA, USA.; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Pico AR; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Red-Horse K; Department of Biology, Stanford University, Stanford, CA, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Ellisman MH; National Center for Microscopy and Imaging Research, Center for Research on Biological Systems, University of California San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Krogan NJ; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; COVID-19 Research Group (QCRG), University of California San Francisco, San Francisco, CA, USA., Bouhaddou M; Department of Microbiology, Immunology and Molecular Genetics (MIMG), University of California Los Angeles, Los Angeles, CA, USA.; Institute for Quantitative and Computational Biosciences (QCBio), University of California Los Angeles, Los Angeles, CA, USA., Ott M; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA.; COVID-19 Research Group (QCRG), University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Greene WC; Gladstone Institute of Virology, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu., Akassoglou K; Center for Neurovascular Brain Immunology at Gladstone and UCSF, San Francisco, CA, USA. katerina.akassoglou@gladstone.ucsf.edu.; Gladstone Institute of Neurological Disease, San Francisco, CA, USA. katerina.akassoglou@gladstone.ucsf.edu.; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. katerina.akassoglou@gladstone.ucsf.edu.

Publikováno v: Nature [Nature] 2024 Sep; Vol. 633 (8031), pp. 905-913. Date of Electronic Publication: 2024 Aug 28.

Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.

Autor: Li L; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Matsui Y; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Prahl MK; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.; Division of Pediatric Infectious Diseases and Global Health, University of California San Francisco, San Francisco, CA, USA., Cassidy AG; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Golan Y; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Jigmeddagva U; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Ozarslan N; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Lin CY; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Buarpung S; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Gonzalez VJ; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Chidboy MA; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Basilio E; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA., Lynch KL; Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA., Song D; Division of Neonatology, Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, CA, USA., Jegatheesan P; Division of Neonatology, Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, CA, USA., Rai DS; Stanford-O'Connor Family Medicine Residency Program, Division of Family Medicine, Stanford University, Palo Alto, CA, USA., Govindaswami B; Division of Neonatology, Department of Pediatrics, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA., Needens J; Department of Obstetrics and Gynecology, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA., Rincon M; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA., Myatt L; Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA., Taha TY; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Montano M; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA., Ott M; Gladstone Institute of Virology, San Francisco, CA, USA.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Greene WC; Gladstone Institute of Virology, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Michael Hulton Center for HIV Cure Research at Gladstone, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.; Departments of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu., Gaw SL; Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA. stephanie.gaw@ucsf.edu.; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA. stephanie.gaw@ucsf.edu.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Aug 27; Vol. 9 (1), pp. 156. Date of Electronic Publication: 2024 Aug 27.

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids.

Autor: Simoneau CR; Gladstone Institute of Virology, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Chen PY; Gladstone Institute of Virology, San Francisco, CA, USA., Xing GK; Chan-Zuckerberg Biohub, San Francisco, CA, USA.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Hayashi JM; Gladstone Institute of Virology, San Francisco, CA, USA., Chen IP; Gladstone Institute of Virology, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA., Khalid MM; Gladstone Institute of Virology, San Francisco, CA, USA., Meyers NL; Gladstone Institute of Virology, San Francisco, CA, USA., Taha TY; Gladstone Institute of Virology, San Francisco, CA, USA., Leon KE; Gladstone Institute of Virology, San Francisco, CA, USA.; Medical Scientist Training Program, University of California San Francisco, San Francisco, CA, USA., Suryawanshi RK; Gladstone Institute of Virology, San Francisco, CA, USA., McCavitt-Malvido M; Gladstone Institute of Virology, San Francisco, CA, USA., Ashuach T; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Fontaine KA; Gladstone Institute of Virology, San Francisco, CA, USA., Rodriguez L; ImmunoX CoLabs, University of California San Francisco, San Francisco, CA, USA., Joehnk B; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Walcott K; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Vasudevan S; Medical Service, San Francisco VA Healthcare System, San Francisco, CA, USA., Fang X; Department of Medicine and Department of Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Maishan M; Department of Medicine and Department of Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Schultz S; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Roose JP; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA., Matthay MA; Department of Medicine and Department of Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Sil A; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Arjomandi M; Medical Service, San Francisco VA Healthcare System, San Francisco, CA, USA.; Division of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Yosef N; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. nir.yosef@weizmann.ac.il.; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel. nir.yosef@weizmann.ac.il., Ott M; Gladstone Institute of Virology, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.; Chan-Zuckerberg Biohub, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. melanie.ott@gladstone.ucsf.edu.

Publikováno v: Scientific reports [Sci Rep] 2024 Jul 04; Vol. 14 (1), pp. 15351. Date of Electronic Publication: 2024 Jul 04.

Previous exposure to Spike-providing parental strains confers neutralizing immunity to XBB lineage and other SARS-CoV-2 recombinants in the context of vaccination.

Autor: Suryawanshi RK; Gladstone Institutes, San Francisco, CA, USA., Taha TY; Gladstone Institutes, San Francisco, CA, USA., McCavitt-Malvido M; Gladstone Institutes, San Francisco, CA, USA., Silva I; Curative Inc., Monrovia, CA, USA., Khalid MM; Gladstone Institutes, San Francisco, CA, USA., Syed AM; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA., Chen IP; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California San Francisco, San Francisco, CA, USA., Saldhi P; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Sreekumar B; Gladstone Institutes, San Francisco, CA, USA., Montano M; Gladstone Institutes, San Francisco, CA, USA., Foresythe K; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Tabata T; Gladstone Institutes, San Francisco, CA, USA., Kumar GR; Gladstone Institutes, San Francisco, CA, USA., Sotomayor-Gonzalez A; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Servellita V; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Gliwa A; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Nguyen J; Department of Laboratory Medicine, University of California, San Francisco, CA, USA., Kojima N; Curative Inc., Monrovia, CA, USA., Arellanor T; Curative Inc., Monrovia, CA, USA., Bussanich A; Curative Inc., Monrovia, CA, USA., Hess V; Curative Inc., Monrovia, CA, USA., Shacreaw M; Curative Inc., Monrovia, CA, USA., Lopez L; Curative Inc., Monrovia, CA, USA., Brobeck M; Curative Inc., Monrovia, CA, USA., Turner F; Curative Inc., Monrovia, CA, USA., Wang Y; Curative Inc., Monrovia, CA, USA., Ghazarian S; Curative Inc., Monrovia, CA, USA., Davis G; Curative Inc., Monrovia, CA, USA., Rodriguez D; Curative Inc., Monrovia, CA, USA., Doudna J; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA.; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA, USA., Spraggon L; Curative Inc., Monrovia, CA, USA., Chiu CY; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA., Ott M; Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute COVID-19 Research Group (QCRG), University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2023 Dec; Vol. 12 (2), pp. 2270071. Date of Electronic Publication: 2023 Oct 31.

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo .

Autor: Taha TY; Gladstone Institutes, San Francisco, CA 94158., Suryawanshi RK; Gladstone Institutes, San Francisco, CA 94158., Chen IP; Gladstone Institutes, San Francisco, CA 94158.; University of California San Francisco, San Francisco, CA 94158., Correy GJ; University of California San Francisco, San Francisco, CA 94158.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158., O'Leary PC; University of California San Francisco, San Francisco, CA 94158., Jogalekar MP; University of California San Francisco, San Francisco, CA 94158., McCavitt-Malvido M; Gladstone Institutes, San Francisco, CA 94158., Diolaiti ME; University of California San Francisco, San Francisco, CA 94158., Kimmerly GR; Gladstone Institutes, San Francisco, CA 94158., Tsou CL; Gladstone Institutes, San Francisco, CA 94158., Martinez-Sobrido L; Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Krogan NJ; University of California San Francisco, San Francisco, CA 94158., Ashworth A; University of California San Francisco, San Francisco, CA 94158., Fraser JS; University of California San Francisco, San Francisco, CA 94158.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94158., Ott M; Gladstone Institutes, San Francisco, CA 94158.; University of California San Francisco, San Francisco, CA 94158.; Chan Zuckerberg Biohub - San Francisco, San Francisco, CA 94158.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 10. Date of Electronic Publication: 2023 May 10.