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Design, synthesis and biological activities of 5Hdibenzo[ b,f]azepine-5-carboxamide derivatives; Targeted hippocampal trypsin inhibition as a novel approach to treat epileptogenesis

Autor: Taha Iqbal, Mohsin Abbas Khan, Irshad Ahmad, Fahad Mehmood Khan

Publikováno v: Tropical Journal of Pharmaceutical Research; Vol. 21 No. 2 (2022); 303-312

Purpose: To synthesize anticonvulsant drug derivatives that target protease-activated receptor generated epileptic seizures.Method: Varieties of carbamazepine-based Schiff bases were designed with different aldehydes and ketones, and evaluated for in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a9e545f8bb4d3a372514dc38249c41
https://www.ajol.info/index.php/tjpr/article/view/224485

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Macro and Micro-Vascular Complications and their Risk Factors in Diabetes Mellitus Patients of Southern Punjab, Pakistan

Autor: Muhammad Usman, Narjis Batool, Abu Bakar Ahmed, Ali Hassan Gillani, Taha Iqbal, Sadia Bashir, Asim Mustafa

Publikováno v: Journal of Pharmacy Practice and Community Medicine. 4:66-71

Background: Diabetes is defined as syndrome and is accompanied by number of micro and macro-vascular complications. The burden is quite high in developing countries so the main aim of this study is to evaluate complications in diabetes patients of Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b34a7559b637a2ffa350d3ffac508a97
https://doi.org/10.5530/jppcm.2018.2.17

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Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma

Autor: Jong-Wook Park, Kyoung-jin Min, Taeg Kyu Kwon, Ji Hoon Jang, Shin Kim, Tae-Jin Lee, Taha Iqbal, Eun-Ik Son

Publikováno v: Toxicology in Vitro. 27:588-596

Helenalin, a sesquiterpene lactone, exhibits anti-inflammatory and anti-tumor activities. Here, we investigated whether helenalin could induce apoptosis in human renal carcinoma Caki cells. Helenalin increased apoptosis in dose dependent manner in Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622d5191f959bf8df69189345fd7e858
https://doi.org/10.1016/j.tiv.2012.10.014

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Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism

Autor: Taeg Kyu Kwon, Yung Hyun Choi, Eun-Jung Park, Ji Hoon Jang, Bo Ram Seo, Seon Min Woo, Kyoung-jin Min, Sang-Hyun Kim, Tae-Jin Lee, Taha Iqbal, Jun Hee Lim

Publikováno v: Chemico-biological interactions. 197(1)

Rottlerin, a selective inhibitor of novel isoforms of protein kinase C δ (PKC δ), has been shown to exert multiple effects on cancer cells, including inhibition of cell proliferation and migration. However, the molecular mechanisms responsible for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e34d8e9964e63037f26b0385090a24
https://pubmed.ncbi.nlm.nih.gov/22410117

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