Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Taha F S, Ali"'
Autor:
Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, Stefan Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi
Publikováno v:
ACS Omega, Vol 9, Iss 32, Pp 34358-34369 (2024)
Externí odkaz:
https://doaj.org/article/0622e5e444ce4009a24da2b2b6498639
Autor:
Lamya H. Al-Wahaibi, Ali M. Elshamsy, Taha F. S. Ali, Bahaa G. M. Youssif, S. Bräse, Mohamed Abdel-Aziz, Nawal A. El-Koussi
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
A novel series of dihydropyrimidine/sulphonamide hybrids 3a–j with anti-inflammatory properties have been developed and tested as dual mPGES-1/5-LOX inhibitors. In vitro assay, results showed that compounds 3c, 3e, 3h, and 3j were the most effectiv
Externí odkaz:
https://doaj.org/article/0ac04f65ef574dc18e937444ce77c50f
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-31 (2023)
Abstract Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML) patients. These mutations are accompanied by poor clinical response, although all the
Externí odkaz:
https://doaj.org/article/2b723de9318e4bd5922bddc9cc3dd5f8
Autor:
Aya Soudi, Onur Bender, Ismail Celik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B. Elkaeed, Aisha A. Alsfouk, Elshimaa M. N. Abdelhafez, Omar M. Aly, Wolfgang Sippl, Taha F. S. Ali
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 659 (2024)
Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase family which is abundantly expressed in individuals with acute leuke
Externí odkaz:
https://doaj.org/article/56f37112a74842d3a69e8d674c6d9fe3
Autor:
Mahmoud A. A. Ibrahim, Khlood A. A. Abdeljawaad, Eslam Roshdy, Dina E. M. Mohamed, Taha F. S. Ali, Gamal A. Gabr, Laila A. Jaragh-Alhadad, Gamal A. H. Mekhemer, Ahmed M. Shawky, Peter A. Sidhom, Alaa H. M. Abdelrahman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD+-dependent and organize several biological processes. Different forms of cancer have been associated with dysregulation of SIRT2 activ
Externí odkaz:
https://doaj.org/article/acf4d8428b04434989e4c8b794a5edda
Autor:
Jowaher Alanazi, Onur Bender, Rumeysa Dogan, Jonaid Ahmad Malik, Arzu Atalay, Taha F. S. Ali, Eman A. M. Beshr, Ahmed M. Shawky, Omar M. Aly, Yasir Nasser H. Alqahtani, Sirajudheen Anwar
Publikováno v:
Molecules, Vol 28, Iss 13, p 5253 (2023)
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies less respons
Externí odkaz:
https://doaj.org/article/5303d8e4c3e044708c3105bf43011a3b
Autor:
Taha F. S. Ali, Halil I. Ciftci, Mohamed O. Radwan, Eslam Roshdy, Ahmed M. Shawky, Mohammed A. S. Abourehab, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Publikováno v:
Pharmaceuticals, Vol 15, Iss 4, p 426 (2022)
The inhibition of glycogen synthase kinase 3β (GSK3β) activity through pharmacological intervention represents a promising approach for treating challenging neurodegenerative disorders like Alzheimer’s disease. Similarly, abnormal tau aggregate a
Externí odkaz:
https://doaj.org/article/511fafb30bc245388d6afa3169bad638
Autor:
Onur Bender, Ismail Celik, Rumeysa Dogan, Arzu Atalay, Mai E. Shoman, Taha F. S. Ali, Eman A. M. Beshr, Mahmoud Mohamed, Eman Alaaeldin, Ahmed M. Shawky, Eman M. Awad, Al-Shaimaa F. Ahmed, Kareem M. Younes, Mukhtar Ansari, Sirajudheen Anwar
Publikováno v:
ACS Omega. 8:6968-6981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c1642e1022d37b0a51ce749076e16c6
https://doi.org/10.1021/acsomega.2c07793
https://doi.org/10.1021/acsomega.2c07793
Autor:
Momen R. Fareed, Mai E. Shoman, Mohammed I. A. Hamed, Mohamed Badr, Hanin A. Bogari, Sameh S. Elhady, Tarek S. Ibrahim, Gamal El-Din A. Abuo-Rahma, Taha F. S. Ali
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1114 (2021)
A series of 3-benzylideneindolin-2-one compounds was designed and synthesized based on combretastatin A-4 and compound IC261, a dual casein kinase (CK1)/tubulin polymerization inhibitor, taking into consideration the pharmacophore required for EGFR-t
Externí odkaz:
https://doaj.org/article/1fa090297e6e4a839f74fdf924fcba24
Autor:
Anwar, Jowaher Alanazi, Onur Bender, Rumeysa Dogan, Jonaid Ahmad Malik, Arzu Atalay, Taha F. S. Ali, Eman A. M. Beshr, Ahmed M. Shawky, Omar M. Aly, Yasir Nasser H. Alqahtani, Sirajudheen
Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 5253
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies less respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0183c3b35d48c4ca7b0e97dafe82626f