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Akademický článek

Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.

Autor: Kenzie D M Birse, Amy L Cole, Taha Hirbod, Lyle McKinnon, Terry B Ball, Garrett R Westmacott, Joshua Kimani, Frank Plummer, Alexander M Cole, Adam Burgener, Kristina Broliden

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130404 (2015)

Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors that are over-expressed in CVS from female

Externí odkaz: https://doaj.org/article/646de3a010c44103ace0a72eb4b4c6ee

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Akademický článek

Correction: Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.

Autor: Kenzie D M Birse, Amy L Cole, Taha Hirbod, Lyle McKinnon, Terry B Ball, Garrett R Westmacott, Joshua Kimani, Frank Plummer, Alexander M Cole, Adam Burgener, Kristina Broliden

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134196 (2015)

Externí odkaz: https://doaj.org/article/fd62a8c401a543559340a372e023d41e

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Akademický článek

HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.

Autor: Taha Hirbod, Xiangrong Kong, Godgrey Kigozi, Anthony Ndyanabo, David Serwadda, Jessica L Prodger, Aaron A Tobian, Fred Nalugoda, Maria J Wawer, Kamnoosh Shahabi, Olga L Rojas, Jennifer L Gommerman, Kristina Broliden, Rupert Kaul, Ronald H Gray

Publikováno v: PLoS Pathogens, Vol 10, Iss 10, p e1004416 (2014)

BackgroundThe foreskin is the site of most HIV acquisition in uncircumcised heterosexual men. Although HIV-exposed, seronegative (HESN) uncircumcised men demonstrate HIV-neutralizing IgA and increased antimicrobial peptides (AMPs) in the foreskin pre

Externí odkaz: https://doaj.org/article/fb6f8a3c7bfe484f8348c03156744fad

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Akademický článek

HIV-neutralizing activity of cationic polypeptides in cervicovaginal secretions of women in HIV-serodiscordant relationships.

Autor: Pauline Levinson, Robert Y Choi, Amy L Cole, Taha Hirbod, Samuel Rhedin, Barbara Payne, Brandon L Guthrie, Rose Bosire, Alexander M Cole, Carey Farquhar, Kristina Broliden

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e31996 (2012)

HIV exposed seronegative (HESN) women represent the population most in need of a prophylactic antiviral strategy. Mucosal cationic polypeptides can potentially be regulated for this purpose and we here aimed to determine their endogenous expression a

Externí odkaz: https://doaj.org/article/4d433ece1b14493bba698b3380da8243

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Akademický článek

No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda.

Autor: Minh H Dinh, Taha Hirbod, Godfrey Kigozi, Eneniziaogochukwu A Okocha, Gianguido C Cianci, Xiangrong Kong, Jessica L Prodger, Kristina Broliden, Rupert Kaul, David Serwadda, Maria J Wawer, Ronald H Gray, Thomas J Hope

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41271 (2012)

It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications for circumcision. We test

Externí odkaz: https://doaj.org/article/63ffbd3615a040d79c1651df591891e7

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Akademický článek

Feasibility and safety of cervical biopsy sampling for mucosal immune studies in female sex workers from Nairobi, Kenya.

Autor: Klara Hasselrot, Juliana Cheruiyot, Joshua Kimani, Terry B Ball, Rupert Kaul, Taha Hirbod

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47570 (2012)

There is an urgent need to improve our understanding of the mucosal immuno-pathogenesis of HIV acquisition in the female genital tract, particularly in high-risk women such as female sex workers (FSWs). Cervical biopsy samples offer technical advanta

Externí odkaz: https://doaj.org/article/c75abbb4bac04fd781f78ae36757e5fc

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Akademický článek

Detection of intraepithelial and stromal Langerin and CCR5 positive cells in the human endometrium: potential targets for HIV infection.

Autor: Tove Kaldensjö, Pernilla Petersson, Anna Tolf, Gareth Morgan, Kristina Broliden, Taha Hirbod

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21344 (2011)

Both the upper (endocervix and uterus) and lower (ectocervix and vagina) female genital tract mucosa are considered to be target sites for sexual transmission of HIV. There are a few reports on the T cell and antigen-presenting cell distribution in h

Externí odkaz: https://doaj.org/article/4cee93a1b9204084b408a030c22dabd4

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Akademický článek

In situ distribution of HIV-binding CCR5 and C-type lectin receptors in the human endocervical mucosa.

Autor: Taha Hirbod, Tove Kaldensjö, Kristina Broliden

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25551 (2011)

The endocervical mucosa is believed to be a primary site of HIV transmission. However, to date there is little known about the distribution of the HIV co-receptor CCR5 and the HIV-binding C-type lectin receptors, including Langerin, dendritic cell (D

Externí odkaz: https://doaj.org/article/4c3c33ba9dbc46b6be6af96818e3fb3c

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