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Akademický článek

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

Publikováno v: eLife, Vol 12 (2024)

The chromatin-associated protein WD Repeat Domain 5 (WDR5) is a promising target for cancer drug discovery, with most efforts blocking an arginine-binding cavity on the protein called the ‘WIN’ site that tethers WDR5 to chromatin. WIN site inhibi

Externí odkaz: https://doaj.org/article/843d9e309e8c4e569cdd20374b77da61

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Akademický článek

418 The antiplatelet effects of EPA, an omega-3 fatty acid, are mediated by its 12-lipoxygenase metabolite, 12-HEPE

Autor: Krista Goerger, Taekyu Lee, Devin Gilmore, Michelle Tran, Theodore R. Holman, Michael Holinstat

Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 124-125 (2024)

OBJECTIVES/GOALS: To determine whether cardioprotective effects observed in individuals taking dietary supplementation with eicosapentaenoic acid (EPA), an ω-3 polyunsaturated fatty acid, are realized by altering platelet function, and if these effe

Externí odkaz: https://doaj.org/article/c467527b551f4b9691d722308df0cb8c

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Akademický článek

Music for Sleep and Wake-Up: An Empirical Study

Autor: Taekyu Lee, Seong-Eun Moon, Jongsoo Baek, Jong-Seok Lee, Songkuk Kim

Publikováno v: IEEE Access, Vol 7, Pp 145816-145828 (2019)

In this paper, we present our study on investigating the effect of music for sleep induction and wake-up. Unlike existing studies that mostly focused on understanding how specific types of music affect sleep for insomnia patients or older people in l

Externí odkaz: https://doaj.org/article/c4375f97b6b9469eb291aa2dedf8fc4b

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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

Publikováno v: Proceedings of the National Academy of Sciences. 120

WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of the mixed lineage leukemia MLL/SET complex and localizes MY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55525b23552d424473dfa053dbc6302
https://doi.org/10.1073/pnas.2211297120

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0854 Observation-based Diurnal Sleepiness Inventory (ODSI) is associated with Objective Sleepiness via Psychomotor Vigilance Task

Autor: Victoria Pak, Kate Russell, Nalaka Gooneratne, John Cox, Stijn Servaes, Taekyu Lee, Hakki Onen, Fannie Onen

Publikováno v: SLEEP. 46:A376-A377

Introduction The Epworth Sleepiness Scale (ESS) is commonly used to assess excessive daytime sleepiness, but its accuracy is limited. In this study, we aim to compare the ESS with the Observation-based Diurnal Sleepiness Inventory (ODSI), a subjectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a96a638f75b87950a62574426081c7af
https://doi.org/10.1093/sleep/zsad077.0854

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Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3)

Autor: W Rush Scaggs, Kevin B Teuscher, Kelvin Luong, Taekyu Lee, Tyson A. Rietz, Keisuke Yoshida, Jonathan J. Mills, Lance T Lepovitz, Rocco D. Gogliotti, Stephen W. Fesik

Publikováno v: Journal of Medicinal Chemistry. 64:14757-14772

T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3; HAVCR2) has emerged as an attractive immune checkpoint target for cancer immunotherapy. TIM-3 is a negative regulator of the systemic immune response to cancer and is expressed on s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e23c12375edde6af4f45b7ab5bec67e
https://doi.org/10.1021/acs.jmedchem.1c01336

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