Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Taeko Wada"'
Autor:
Kenji Tago, Satoshi Ohta, Chihiro Aoki-Ohmura, Megumi Funakoshi-Tago, Miho Sashikawa, Takeshi Matsui, Yuki Miyamoto, Taeko Wada, Tomoyuki Oshio, Mayumi Komine, Jitsuhiro Matsugi, Yusuke Furukawa, Mamitaro Ohtsuki, Junji Yamauchi, Ken Yanagisawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract NKIRAS1 and NKIRAS2 (also called as κB-Ras) were identified as members of the atypical RAS family that suppress the transcription factor NF-κB. However, their function in carcinogenesis is still controversial. To clarify how NKIRAS acts on
Externí odkaz:
https://doaj.org/article/ea99244ee1894dc1b85b8bd3c1a2455e
Autor:
Nobuya Hiraoka, Jiro Kikuchi, Takahiro Yamauchi, Daisuke Koyama, Taeko Wada, Mitsuyo Uesawa, Miyuki Akutsu, Shigehisa Mori, Yuichi Nakamura, Takanori Ueda, Yasuhiko Kano, Yusuke Furukawa
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90675 (2014)
Bendamustine has shown considerable clinical activity against indolent lymphoid malignancies as a single agent or in combination with rituximab, but combination with additional anti-cancer drugs may be required for refractory and/or relapsed cases as
Externí odkaz:
https://doaj.org/article/86532434e6ac4ca184c34d22daf3e22a
Autor:
Jiro Kikuchi, Naoya Shibayama, Satoshi Yamada, Taeko Wada, Masaharu Nobuyoshi, Tohru Izumi, Miyuki Akutsu, Yasuhiko Kano, Kanako Sugiyama, Mio Ohki, Sam-Yong Park, Yusuke Furukawa
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60649 (2013)
The proteasome is a proteolytic machinery that executes the degradation of polyubiquitinated proteins to maintain cellular homeostasis. Proteasome inhibition is a unique and effective way to kill cancer cells because they are sensitive to proteotoxic
Externí odkaz:
https://doaj.org/article/f4d1bbfc9fca4b3085df27986acf46d8
Autor:
Junya Tamaoki, Mitsuyoshi Nakao, Ryo Abe, Makoto Kobayashi, Shinjiro Hino, Yusuke Furukawa, Taeko Wada, Hiroshi Kaneko, Miki Takeuchi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
LSD1/KDM1A is a widely conserved lysine-specific demethylase that removes methyl groups from methylated proteins, mainly histone H3. We previously isolated the zebrafish LSD1 gene and demonstrated that it is required for primitive hematopoiesis. Rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954c69e5afc9520d17bbe3a9aea8f426
http://link.springer.com/article/10.1038/s41598-020-65428-9
http://link.springer.com/article/10.1038/s41598-020-65428-9
Autor:
Jitsuhiro Matsugi, Yuki Miyamoto, Mamitaro Ohtsuki, Chihiro Aoki-Ohmura, Tomoyuki Oshio, Taeko Wada, Miho Sashikawa, Yusuke Furukawa, Mayumi Komine, Satoshi Ohta, Takeshi Matsui, Junji Yamauchi, Kenji Tago, Megumi Funakoshi-Tago, Ken Yanagisawa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
NKIRAS1 and NKIRAS2 (also called as κB-Ras) were identified as members of the atypical RAS family that suppress the transcription factor NF-κB. However, their function in carcinogenesis is still controversial. To clarify how NKIRAS acts on cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace2ba9790fa5f949de79fe66bbf7318
http://europepmc.org/articles/PMC8526694
http://europepmc.org/articles/PMC8526694
Publikováno v:
Leukemia research. 82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e3244fbf301e630ecb67c0ceba1ed0
https://pubmed.ncbi.nlm.nih.gov/31152920
https://pubmed.ncbi.nlm.nih.gov/31152920
Autor:
Yusuke Furukawa, Taeko Wada, Jiro Kikuchi, Daisuke Koyama, Masaharu Nobuyoshi, Yasuhiko Kano, Tohru Izumi, Satoshi Yamada, Miyuki Akutsu
Publikováno v:
Journal of Biological Chemistry. 288:25593-25602
Bortezomib therapy is now indispensable for multiple myeloma, but is associated with patient inconvenience due to intravenous injection and emerging drug resistance. The development of orally active proteasome inhibitors with distinct mechanisms of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d060bb10b5e58c60104d482e0009a58
https://doi.org/10.1074/jbc.m113.480574
https://doi.org/10.1074/jbc.m113.480574
Publikováno v:
Journal of Cellular Physiology. 227:1138-1147
Latexin is the only known carboxypeptidase A inhibitor in mammals and shares structural similarity with cystatin C, suggesting that latexin regulates the abundance of as yet unidentified target proteins. A forward genetic approach revealed that latex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94afca429b90dc7d309405e82ee316c0
https://doi.org/10.1002/jcp.22834
https://doi.org/10.1002/jcp.22834
Publikováno v:
Folia Pharmacologica Japonica. 138:26-32
ベンダムスチン（トレアキシン®）はプリンアナログ様骨格にアルキル基が結合したハイブリッドな抗がん薬である．作用機序はDNAアルキル化が主体と考えられ，代謝拮抗作用について
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e25535aecf8f541a867b5921ea6310
https://doi.org/10.1254/fpj.138.26
https://doi.org/10.1254/fpj.138.26
Autor:
Yusuke Furukawa, Tohru Izumi, Jiro Kikuchi, Taeko Wada, R Shimizu, Miyuki Akutsu, Yasuhiko Kano, Masaharu Nobuyoshi, Keiya Ozawa, Kaoru Noborio-Hatano, Kanae Mitsunaga
Publikováno v:
Blood. 116:406-417
Bortezomib is now widely used for the treatment of multiple myeloma (MM); however, its action mechanisms are not fully understood. Despite the initial results, recent investigations have indicated that bortezomib does not inactivate nuclear factor-κ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ca05018de28bef79b70e4aa83f1ae8
https://doi.org/10.1182/blood-2009-07-235663
https://doi.org/10.1182/blood-2009-07-235663