Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Taek-Chin Cheong"'
Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
Autor:
Taek-Chin Cheong, Ahram Jang, Qi Wang, Giulia C. Leonardi, Biagio Ricciuti, Joao V. Alessi, Alessandro Di Federico, Mark M. Awad, Maria K. Lehtinen, Marian H. Harris, Roberto Chiarle
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions are followed typical recurrent patterns, but the underl
Externí odkaz:
https://doaj.org/article/f91a851ffb1747f5bdae9ea30cb198bb
Autor:
Bo Gi Park, Yu Jin Kim, Ji Hyun Min, Taek-Chin Cheong, Sang Hwan Nam, Nam-Hyuk Cho, Young Keun Kim, Kyu Back Lee
Publikováno v:
Nanoscale Research Letters, Vol 15, Iss 1, Pp 1-10 (2020)
Abstract Magnetite (Fe3O4)-gold (Au) core-shell nanoparticles (NPs) have unique magnetic and optical properties. When combined with biological moieties, these NPs can offer new strategies for biomedical applications, such as drug delivery and cancer
Externí odkaz:
https://doaj.org/article/865eb5260d7d4b44bcdc20c2cbeebbf3
Autor:
Chang Jiang, Stephen J. Trudeau, Taek-Chin Cheong, Rui Guo, Mingxiang Teng, Liang Wei Wang, Zhonghao Wang, Chiara Pighi, Carole Gautier-Courteille, Yijie Ma, Sizun Jiang, Chong Wang, Bo Zhao, Luc Paillard, John G. Doench, Roberto Chiarle, Benjamin E. Gewurz
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1307-1322.e8 (2019)
Summary: CD40 has major roles in B cell development, activation, and germinal center responses. CD40 hypoactivity causes immunodeficiency whereas its overexpression causes autoimmunity and lymphomagenesis. To systematically identify B cell autonomous
Externí odkaz:
https://doaj.org/article/b74d5505048f47989a48f9086351ba64
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the induction of class switch recombination, opening up p
Externí odkaz:
https://doaj.org/article/6bcc873a3691474593b9a5309921326e
Autor:
Sooghee Chang, Youn-Hee Kim, Young-Joo Kim, Young-Woo Kim, Sungyoon Moon, Yong Yook Lee, Jin Sun Jung, Youngsoo Kim, Hi-Eun Jung, Tae-Joo Kim, Taek-Chin Cheong, Hye-Jung Moon, Jung-Ah Cho, Hang-Rae Kim, Dohyun Han, Yirang Na, Seung-Hyeok Seok, Nam-Hyuk Cho, Hai-Chon Lee, Eun-Hee Nam, Hyosuk Cho, Murim Choi, Nagahiro Minato, Seung-Yong Seong
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against ren
Externí odkaz:
https://doaj.org/article/58787300b827444c9af4af7cbc772af3
Autor:
Rafael B. Blasco, Elif Karaca, Chiara Ambrogio, Taek-Chin Cheong, Emre Karayol, Valerio G. Minero, Claudia Voena, Roberto Chiarle
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1219-1227 (2014)
Generation of genetically engineered mouse models (GEMMs) for chromosomal translocations in the endogenous loci by a knockin strategy is lengthy and costly. The CRISPR/Cas9 system provides an innovative and flexible approach for genome engineering of
Externí odkaz:
https://doaj.org/article/27425d0273844ee9a4e980ce7d8f1210
Autor:
Ji-Hye Choi, Taek-Chin Cheong, Na-Young Ha, Youngho Ko, Chung-Hyun Cho, Ju-Hong Jeon, Insuk So, In-Kyu Kim, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 1, p e1981 (2013)
BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cells that link innate and adaptive immune responses, playing a pivotal role in triggering antigen-specific immunity. Antigen uptake by DCs induces maturational changes that inc
Externí odkaz:
https://doaj.org/article/79824e88e8ee486d873483a49e4972ae
Autor:
Jake June-Koo Lee, Youngsook Lucy Jung, Taek-Chin Cheong, Jose Espejo Valle-Inclan, Chong Chu, Doga C. Gulhan, Viktor Ljungström, Hu Jin, Vinayak V. Viswanadham, Emma V. Watson, Isidro Cortés-Ciriano, Stephen J. Elledge, Roberto Chiarle, David Pellman, Peter J. Park
Publikováno v:
Nature.
Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1–3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2408b0b5f71019055948e923bf7aca7
https://doi.org/10.1038/s41586-023-06057-w
https://doi.org/10.1038/s41586-023-06057-w
Autor:
Taek-Chin Cheong, Ahram Jang, Qi Wang, Giulia C. Leonardi, Maria K. Lehtinen, Marian H. Harris, Roberto Chiarle
Publikováno v:
Cancer Research. 83:313-313
Introduction: Tyrosine kinase (TK) fusions are common events in the development of resistance to targeted therapy for non-small cell lung cancer (NSCLC) and others. The mechanisms by which recurrent breakpoints are generated in solid tumors and by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77ba1852670273718f48965ba671191e
https://doi.org/10.1158/1538-7445.am2023-313
https://doi.org/10.1158/1538-7445.am2023-313
Autor:
Jessica Hossa, Giulia Costanza Leonardi, Chiara Ambrogio, Taek-Chin Cheong, Ines Mota, Qi Wang, Cinzia Martinengo, Roberto Chiarle, Birgit Geoerger, Luca Mologni, Carlo Gambacorti-Passerini, Laurence Brugières, Elif Karaca-Atabay, Achille Pich, Nina Prokoph, Carmen Mecca, Suzanne D. Turner, Claudia Voena, Enrico Patrucco, Giulia Mura
Publikováno v:
Blood
Anaplastic large cell lymphomas (ALCLs) frequently carry oncogenic fusions involving the anaplastic lymphoma kinase (ALK) gene. Targeting ALK using tyrosine kinase inhibitors (TKIs) is a therapeutic option in cases relapsed after chemotherapy, but TK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad5582f7b1969b4fe80d45b81002ac0
https://hdl.handle.net/2318/1833338
https://hdl.handle.net/2318/1833338
