Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Tae-Wook Chun"'
Autor:
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown. We observe that approximately 1–5% of CD4+ T cells from the bloo
Externí odkaz:
https://doaj.org/article/a62a5df966d346acae50282c12b35957
Autor:
M. Ali Rai, Jana Blazkova, Jesse S. Justement, Victoria Shi, Brooke D. Kennedy, Maegan R. Manning, Mary McLaughlin, Michael C. Sneller, Alice K. Pau, Susan Moir, Tae-Wook Chun
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105151- (2024)
Summary: Background: People living with HIV (PLWH) with multidrug-resistant (MDR) viruses have limited therapeutic options and present challenges regarding clinical management. Recent studies have shown that passive transfer of combination broadly ne
Externí odkaz:
https://doaj.org/article/cf0e1cf67e494855a8394bb7836c7ac3
Autor:
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the
Externí odkaz:
https://doaj.org/article/d1345b938a9e4d4b9d8558446242fdc7
Autor:
Vitaliy A. Matveev, Erik Z. Mihelic, Erika Benko, Patrick Budylowski, Sebastian Grocott, Terry Lee, Chapin S. Korosec, Karen Colwill, Henry Stephenson, Ryan Law, Lesley A. Ward, Salma Sheikh-Mohamed, Geneviève Mailhot, Melanie Delgado-Brand, Adrian Pasculescu, Jenny H. Wang, Freda Qi, Tulunay Tursun, Lela Kardava, Serena Chau, Philip Samaan, Annam Imran, Dennis C. Copertino, Jr., Gary Chao, Yoojin Choi, Robert J. Reinhard, Rupert Kaul, Jane M. Heffernan, R. Brad Jones, Tae-Wook Chun, Susan Moir, Joel Singer, Jennifer Gommerman, Anne-Claude Gingras, Colin Kovacs, Mario Ostrowski
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107915- (2023)
Summary: Older individuals and people with HIV (PWH) were prioritized for COVID-19 vaccination, yet comprehensive studies of the immunogenicity of these vaccines and their effects on HIV reservoirs are not available. Our study on 68 PWH and 23 HIV-ne
Externí odkaz:
https://doaj.org/article/c0a02cfb1ee4418788ae8efa6e553405
Autor:
Eva M. Stevenson, Sandra Terry, Dennis Copertino, Louise Leyre, Ali Danesh, Jared Weiler, Adam R. Ward, Pragya Khadka, Evan McNeil, Kevin Bernard, Itzayana G. Miller, Grant B. Ellsworth, Carrie D. Johnston, Eli J. Finkelsztein, Paul Zumbo, Doron Betel, Friederike Dündar, Maggie C. Duncan, Hope R. Lapointe, Sarah Speckmaier, Nadia Moran-Garcia, Michelle Premazzi Papa, Samuel Nicholes, Carissa J. Stover, Rebecca M. Lynch, Marina Caskey, Christian Gaebler, Tae-Wook Chun, Alberto Bosque, Timothy J. Wilkin, Guinevere Q. Lee, Zabrina L. Brumme, R. Brad Jones
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, the authors show in a cohort of people with HIV, COVID mRNA vaccination is followed by a transient boost in a particular profile of HIV-specific T-cell responses and a corresponding decrease in residual HIV RNA – suggesting productive immune
Externí odkaz:
https://doaj.org/article/d9cd2a88e3f64b5bb298b5bf37dbca63
Autor:
Felipe Lopes de Assis, Kenneth B. Hoehn, Xiaozhen Zhang, Lela Kardava, Connor D. Smith, Omar El Merhebi, Clarisa M. Buckner, Krittin Trihemasava, Wei Wang, Catherine A. Seamon, Vicky Chen, Paul Schaughency, Foo Cheung, Andrew J. Martins, Chi-I Chiang, Yuxing Li, John S. Tsang, Tae-Wook Chun, Steven H. Kleinstein, Susan Moir
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112780- (2023)
Summary: Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell an
Externí odkaz:
https://doaj.org/article/0741d21fc63c4181b8b82bf41955424e
Autor:
Brooke D. Kennedy, Jana Blazkova, Jesse S. Justement, Victoria Shi, M. Ali Rai, Maegan R. Manning, Lauren Praiss, Kathleen Gittens, Paul A. Wender, Sean Patro, Xiaolin Wu, Susan Moir, Tae-Wook Chun
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/e547c1c06cc24ff0a2b852c649742a7e
Autor:
Jason Segura, Joanna Ireland, Zhongcheng Zou, Gwynne Roth, Julianna Buchwald, Thomas J Shen, Elizabeth Fischer, Susan Moir, Tae-Wook Chun, Peter D Sun
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281087 (2023)
HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking the caspas
Externí odkaz:
https://doaj.org/article/db16d094b4b9452b932e1d4929bc1688
Autor:
M. Ali Rai, Tae‐Wook Chun
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/fd8005a415d044ceb6a762c43f58730f
Autor:
Haishan Li, Tyler Lahusen, Lingzhi Xiao, Nidal Muvarak, Jana Blazkova, Tae-Wook Chun, C. David Pauza
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1048-1060 (2020)
Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene the
Externí odkaz:
https://doaj.org/article/537a7b1f723a4249a33ac8a83b49f5da