Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tae-Joon Hong"'
Autor:
Hae-Mi Kim, Kyoung-Jin Kim, Kwanghyun Lee, Myeong Jin Yoon, Jenny Choih, Tae-Joon Hong, Eun Ji Cho, Hak-Jun Jung, Jayoung Kim, Ji Soo Park, Hye Young Na, Yong-Seok Heo, Chae Gyu Park, Heungrok Park, Sungho Han, Donggoo Bae
Publikováno v:
BMC Immunology, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Several PD-1 antibodies approved as anti-cancer therapies work by blocking the interaction of PD-1 with its ligand PD-L1, thus restoring anti-cancer T cell activities. These PD-1 antibodies lack inter-species cross-reactivity, nec
Externí odkaz:
https://doaj.org/article/606d5df8b1b947599105dd20763d2262
Autor:
Yoon Sun Chun, Mi-Yeon Kim, Sun-Young Lee, Mi Jeong Kim, Tae-Joon Hong, Jae Kyong Jeon, Dulguun Ganbat, Hyoung Tae Kim, Sang Seong Kim, Tae-In Kam, Sungho Han
Publikováno v:
Molecular Psychiatry. 27:4770-4780
Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks of AD. The autophagic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3d57bd198571b3757be078e9e3ccc4
https://doi.org/10.1038/s41380-022-01713-5
https://doi.org/10.1038/s41380-022-01713-5
Publikováno v:
Biochemical and Biophysical Research Communications. 482:215-220
Protein phosphatase 5 (PP5) is a serine/threonine phosphatase that belongs to the PPP family phosphatases. PP5 and the other phosphatases of the PPP family share significantly similar catalytic domain structure. Due to this structural similarity, nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260aa5f0d1c982025e767bf1ea1a331d
https://doi.org/10.1016/j.bbrc.2016.11.043
https://doi.org/10.1016/j.bbrc.2016.11.043
Publikováno v:
Journal of Biological Chemistry. 288:215-222
Mammals have two cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones, Chp-1 and melusin, which are homologs of plant Rar1. It has been shown previously that Rar1 CHORD directly interacts with ADP bound to the nucleotide pocket o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c467f622c9658758693d267e5f164b
https://doi.org/10.1074/jbc.m112.398636
https://doi.org/10.1074/jbc.m112.398636
Autor:
Ji-Sook Hahn, Tae-Joon Hong
Publikováno v:
Biochemical and biophysical research communications. 478(4)
NOD1 is an intracellular sensor of innate immunity which is related to a number of inflammatory diseases. NOD1 is known to be difficult to express and purify for structural and biochemical studies. Based on the fact that Hsp90 and its cochaperone SGT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e783bb3ff332de64c4b53e0cb2dfa3bb
https://pubmed.ncbi.nlm.nih.gov/27591899
https://pubmed.ncbi.nlm.nih.gov/27591899
Autor:
Dhanaji Achyutrao Thorat, Tae-Joon Hong, Ji-Sook Hahn, Yong Seo Cho, Munikumar Reddy Doddareddy, Ae Nim Pae, Seon Hee Seo
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:1714-1720
Structure based drug design (SBDD) was used to discover heat shock protein 90 (HSP90) inhibitors useful in the treatment of cancer. By using the crystal structure of HSP90-ligand complex (1uyi), a docking model was prepared and was validated by exter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c18ae312831ab2ce3075f7fe7be8f
https://doi.org/10.1016/j.bmc.2011.01.023
https://doi.org/10.1016/j.bmc.2011.01.023
Publikováno v:
Biosensors and Bioelectronics. 25:1307-1312
A rapid and efficient strategy to detect novel heat shock protein 90 (Hsp90) inhibitors as anti-cancer agents was developed with field-effect transistor (FET) sensor based on carboxylated polypyrrole nanotubes (CPNTs). First of all, the CPNTs were su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd095cc5bb7b29875819e987416084f
https://doi.org/10.1016/j.bios.2009.10.019
https://doi.org/10.1016/j.bios.2009.10.019
Publikováno v:
FEBS letters. 586(16)
Pendrin is a transmembrane chloride/anion exchanger highly expressed in thyroid, kidney, and inner ear. Endoplasmic reticulum (ER)-retention of improperly folded Pendrin mutants is considered as the major cause for Pendred syndrome. However, the fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361d43c23a2b9ee1d8188c6a05660b27
https://pubmed.ncbi.nlm.nih.gov/22750442
https://pubmed.ncbi.nlm.nih.gov/22750442
Autor:
Dhanaji Achyutrao Thorat, Seon Hee Seo, Tae-Joon Hong, Yong Seo Cho, Ji-Sook Hahn, Ae Nim Pae, Munikumar Reddy Doddareddy
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
Novel 2,4-diaminoquinazoline derivatives originating from a virtual screening approach were designed, synthesized and their biological activities as heat shock protein 90 (Hsp90) inhibitors were evaluated. The prepared compounds exhibited significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef05af1c5be770d0e95380a21e6a929
https://pubmed.ncbi.nlm.nih.gov/21353544
https://pubmed.ncbi.nlm.nih.gov/21353544
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Structure-based virtual screening identified pyrimidine-2,4,6-trione and 4H-1,2,4-triazole-3-thiol as novel scaffolds of Hsp90 ATPase inhibitors. Their binding modes in the ATP-binding pocket of Hsp90 were analyzed using AutoDoc program combined with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237a69d8f8deddade92b6cdd74c7b1fc
https://pubmed.ncbi.nlm.nih.gov/19560353
https://pubmed.ncbi.nlm.nih.gov/19560353