Výsledky vyhledávání

Akademický článek

The emerging roles of Shank3 in cardiac function and dysfunction

Autor: Yoonhee Kim, Tae Hee Ko, Chunmei Jin, Yinhua Zhang, Hyae Rim Kang, Ruiying Ma, Huiling Li, Jong-Il Choi, Kihoon Han

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Shank3 is a member of the Shank family proteins (Shank1–3), which are abundantly present in the postsynaptic density (PSD) of neuronal excitatory synapses. As a core scaffold in the PSD, Shank3 plays a critical role in organizing the macromolecular

Externí odkaz: https://doaj.org/article/4809dd1322b645638fa70cb197674b80

Zobrazit plný text záznamu

Akademický článek

The Activation of the LIMK/Cofilin Signaling Pathway via Extracellular Matrix–Integrin Interactions Is Critical for the Generation of Mature and Vascularized Cardiac Organoids

Autor: Ji-Min Noh, Seung-Cheol Choi, Myeong-Hwa Song, Kyung Seob Kim, Seongmin Jun, Jae Hyoung Park, Ju Hyeon Kim, Kyoungmi Kim, Tae Hee Ko, Jong-Il Choi, Jeong-An Gim, Jong-Hoon Kim, Yongjun Jang, Yongdoo Park, Ji Eun Na, Im Joo Rhyu, Do-Sun Lim

Publikováno v: Cells, Vol 12, Iss 16, p 2029 (2023)

The generation of mature and vascularized human pluripotent stem cell-derived cardiac organoids (hPSC-COs) is necessary to ensure the validity of drug screening and disease modeling. This study investigates the effects of cellular aggregate (CA) stem

Externí odkaz: https://doaj.org/article/ef0364a8fad84c03a78242590f64ad95

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Modeling Hypoxic Stress In Vitro Using Human Embryonic Stem Cells Derived Cardiomyocytes Matured by FGF4 and Ascorbic Acid Treatment

Publikováno v: Cells, Vol 10, Iss 10, p 2741 (2021)

Mature cardiomyocytes (CMs) obtained from human pluripotent stem cells (hPSCs) have been required for more accurate in vitro modeling of adult-onset cardiac disease and drug discovery. Here, we found that FGF4 and ascorbic acid (AA) induce differenti

Externí odkaz: https://doaj.org/article/e33e1df90331415bbf35cb3b2f0666f9

Zobrazit plný text záznamu

Stretchable and Directly Patternable Double-Layer Structure Electrodes with Complete Coverage

Autor: Junsung Bang, Junhyuk Ahn, Jinyuan Zhang, Tae Hee Ko, Byeonghak Park, Yong Min Lee, Byung Ku Jung, Sang Yeop Lee, Jehyung Ok, Bong Hoon Kim, Tae-il Kim, Jong-Il Choi, Chi Hwan Lee, Soong Ju Oh

Publikováno v: ACS Nano. 16:12134-12144

Stretchable electrodes are widely used in next-generation wearable electronics. Recent studies incorporated designs that help rigid electrodes attain stretchability. However, these structures exhibited unsatisfactory charge/signal extraction efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d373291dfb58f9c88559aa335e7497ed
https://doi.org/10.1021/acsnano.2c02664

Zobrazit plný text záznamu

Cereblon contributes to cardiac dysfunction by degrading Cav1.2α

Autor: Nammi Park, Jubert Marquez, Trong Kha Pham, Tae Hee Ko, Jae Boum Youm, Min Kim, Seung Hak Choi, Jiyoung Moon, Jessa Flores, Kyung Soo Ko, Byoung Doo Rhee, Ippei Shimizu, Tohru Minamino, Jae Du Ha, Jong Yeon Hwang, Seung Joo Yang, Chul-Seung Park, Hyoung Kyu Kim, Jin Han

Publikováno v: European Heart Journal. 43:1973-1989

Aims Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that was reported to target ion channel proteins. L-type voltage-dependent Ca2+ channel (LTCC) density and dysfunction is a critical player in heart failure with reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c325a8da91ba2231912ccc74c06466
https://doi.org/10.1093/eurheartj/ehac072

Zobrazit plný text záznamu

Akademický článek

mRNA-Driven Generation of Transgene-Free Neural Stem Cells from Human Urine-Derived Cells

Autor: Phil Jun Kang, Daryeon Son, Tae Hee Ko, Wonjun Hong, Wonjin Yun, Jihoon Jang, Jong-Il Choi, Gwonhwa Song, Jangbo Lee, In Yong Kim, Seungkwon You

Publikováno v: Cells, Vol 8, Iss 9, p 1043 (2019)

Human neural stem cells (NSCs) hold enormous promise for neurological disorders, typically requiring their expandable and differentiable properties for regeneration of damaged neural tissues. Despite the therapeutic potential of induced NSCs (iNSCs),

Externí odkaz: https://doaj.org/article/025f57c6ebf542c18644c3605ac06188

Zobrazit plný text záznamu

Plný text ve formátu HTML

Circadian modulation of the cardiac proteome underpins differential adaptation to morning and evening exercise training: an LC-MS/MS analysis

Autor: Jin Han, Hyo-Bum Kwak, Jae Boum Youm, Won Suk Yang, Tae Hee Ko, Sung Ryul Lee, Hyoung Kyu Kim, Dae Yun Seo, Louise Anne Dizon, Chang Shin Yoon, Robin A. McGregor

Publikováno v: Pflügers Archiv - European Journal of Physiology. 472:259-269

All living beings on earth are influenced by the circadian rhythm, the rising and the setting of the sun. The ubiquitous effect of exercise is widely believed to maximize health benefits but has not been formally investigated for cardiac responses in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c09ca74995d9829638614962307b714
https://doi.org/10.1007/s00424-020-02350-z

Zobrazit plný text záznamu

Inhibition of late sodium current via PI3K/Akt signaling prevents cellular remodeling in tachypacing-induced HL-1 atrial myocytes

Autor: Tae Hee Ko, Daun Jeong, Byeongil Yu, Ji Eun Song, Qui Anh Le, Sun-Hee Woo, Jong-Il Choi

Publikováno v: Pflugers Archiv : European journal of physiology.

AbstractAn aberrant late sodium current (INa,Late) caused by a mutation in the cardiac sodium channel (Nav1.5) has emerged as a contributor to electrical remodeling that causes susceptibility to atrial fibrillation (AF). Although downregulation of ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44590060291750fef7dad8c940a8e8a0
https://pubmed.ncbi.nlm.nih.gov/36274100

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání