Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Tae-Chul Moon"'
Autor:
Yasser Tabana, Shima Shahbaz, Dinesh Babu, Marawan Ahmed, Tae Chul Moon, Frederick G. West, Richard Fahlman, Arno G. Siraki, Shokrollah Elahi, Khaled Barakat
Publikováno v:
Medicine in Drug Discovery, Vol 21, Iss , Pp 100178- (2024)
The use of small molecules in immunotherapy is a promising and rapidly growing field with the potential to revolutionize the way we treat a wide range of immunological diseases. The success stories of using small molecules in immunotherapy have been
Externí odkaz:
https://doaj.org/article/7943f7c592da40d2b40141ea4f9de8a4
Autor:
Yasser Tabana, Chih-Hsuan Lin, Dinesh Babu, Ramanaguru Siva‐Piragasam, Ashley A. Ponich, Tae Chul Moon, Arno G. Siraki, Shokrollah Elahi, Richard Fahlman, Frederick G. West, Khaled Barakat
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e21408- (2023)
In the past decade, there has been increasing interest in use of small molecules for immunomodulation. The affinity-based pull-down purification is an essential tool for target identification of small molecules and drug discovery. This study presents
Externí odkaz:
https://doaj.org/article/97bd57ce73784a2dbaa7784999c036ac
Autor:
Maryam Jama, Marawan Ahmed, Anna Jutla, Carson Wiethan, Jitendra Kumar, Tae Chul Moon, Frederick West, Michael Overduin, Khaled H. Barakat
Publikováno v:
Computers in biology and medicine. 152
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a cytoplasmic protein -tyrosine phosphatase encoded by the gene PTPN11. It plays a crucial role in regulating cell growth and differentiation. Specifically, SHP2 is an oncoprot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5404bdfbae5922e5dc32309e5443c6
https://pubmed.ncbi.nlm.nih.gov/36566625
https://pubmed.ncbi.nlm.nih.gov/36566625
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:347-363
Introduction:T cell functions are altered during chronic viral infections and tumor development. This is mainly manifested by significant changes in T cells’ epigenetic and metabolic landscapes, pu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494898b4d5206804af5c3386ceded7c7
https://doi.org/10.1080/14728222.2021.1937123
https://doi.org/10.1080/14728222.2021.1937123
Autor:
Tae Chul Moon, Eduardo Campos-Alberto, Tsuyoshi Yoshimura, Graeme Bredo, Aja M Rieger, Lakshmi Puttagunta, Daniel R Barreda, A Dean Befus, Lisa Cameron
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108595 (2014)
PGD₂ has long been implicated in allergic diseases. Recent cloning of a second PGD₂ receptor, DP2 (also known as CRTh2), led to a greater understanding of the physiological and pathophysiological implications of PGD₂. PGD₂ signaling through D
Externí odkaz:
https://doaj.org/article/705fd2e31e9e47d59fcdaa31ffcc972f
Autor:
Michael Houghton, Khaled Barakat, Xiaoqing Hou, Tae Chul Moon, Harley T. Kurata, Subha Kalyaanamoorthy, Shawn M. Lamothe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to the withdrawal of many drugs from the market over the last decades. Consequently, predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e863aa775d2aceb227e327e760dcd33
https://doi.org/10.1038/s41598-020-72889-5
https://doi.org/10.1038/s41598-020-72889-5
Publikováno v:
Journal of the Nuclear Fuel Cycle and Waste Technology(JNFCWT). 15:91-99
Domestically developed concrete storage casks include an internal canister to maintain the confinement integrity of radioactive materials. In this study, we analyzed the depth of flaws caused by loads that propagate canister weld cracks under normal,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7dbd200565441612654073e7988da6f
https://doi.org/10.7733/jnfcwt.2017.15.1.91
https://doi.org/10.7733/jnfcwt.2017.15.1.91
Autor:
Lai Xu, Michael Smylie, Mary M. Hitt, James A. Nieman, John Walker, Guangzhi Zhang, Joydeb Kumar Kundu, Isobel Okoye, Seyedeh Nargess Hosseini, Nutan Srivastava, William L. Turnbull, Hena Mostafa, Dinesh Babu, Khaled Barakat, Justin Shields, Katharine Cheryl Agopsowicz, Frederick G. West, Tae Chul Moon, D. Lorne Tyrrell, Yasser M Tabana, Appan Srinivas Kandadai, Alexandr Belovodskiy, Marawan Ahmed, Shokrollah Elahi, Aravindhan Ganesan, Elena Arutyunova, Michael Houghton, Arno G. Siraki, M. Joanne Lemieux
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction has emerged as a powerful strategy in cancer immunotherapy. Recently, there have been enormous efforts to develop potent PD-1/PD-L1 inhibitors. In parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33192a72d283c99d168beb83d88a9d6b
https://doi.org/10.1038/s41598-019-48826-6
https://doi.org/10.1038/s41598-019-48826-6
Autor:
Subha, Kalyaanamoorthy, Shawn M, Lamothe, Xiaoqing, Hou, Tae Chul, Moon, Harley T, Kurata, Michael, Houghton, Khaled H, Barakat
Publikováno v:
Scientific reports. 10(1)
Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to the withdrawal of many drugs from the market over the last decades. Consequently, predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::198fb9137ef33715f2aeda879e95637d
https://pubmed.ncbi.nlm.nih.gov/33004839
https://pubmed.ncbi.nlm.nih.gov/33004839
Autor:
Tae Chul Moon, Chris D. St. Laurent, Kurtis Ng, C. Marcet, A. Dean Befus, Harissios Vliagoftis, Javeria Raheem
Publikováno v:
Antiviral research. 171
As a part of innate immune defense, the role of mast cells during viral replication has been incompletely understood. In this study, we characterized and compared the responses of the human mast cell line, LAD2, and human lung epithelial cell line, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e52d033fc12d68d2d9bfdfd7d415d941
https://pubmed.ncbi.nlm.nih.gov/31348951
https://pubmed.ncbi.nlm.nih.gov/31348951