Výsledky vyhledávání - "Tae Kyoung Kwak"

BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells

Autor: Gao Zhang, Shari Pilon-Thomas, Dmitry I. Gabrilovich, Sergio Lavilla-Alonso, Tae Kyoung Kwak, Laxminarasimha Donthireddy, Valerie Moberg, Michael J. Schell, Min Xiao, Cigdem Atay, Vito W. Rebecca, Amod A. Sarnaik, Jeffrey S. Weber, Meenhard Herlyn, Jane L. Messina, Jiufeng Tan, Allison D Richards

Publikováno v: Clin Cancer Res

Purpose: BRAF and MEK inhibitors (BRAFi and MEKi) are actively used for the treatment of metastatic melanoma in patients with BRAFV600E mutation in their tumors. However, the development of resistance to BRAFi and MEKi remains a difficult clinical ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e67b4e81eab1f87788832af58c313f1
https://doi.org/10.1158/1078-0432.ccr-18-2725

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The effects of a randomized trial of brief forms of stress management on RAGE‐associated S100A8/A9 in patients with breast cancer undergoing primary treatment

Autor: Gyong Ha Hwang, Tae Kyoung Kwak, Marc E. Lippman, Erica R. Nahin, Bonnie B. Blomberg, Alain Diaz, Barry I. Hudson, Suzanne C. Lechner, C. Taub, Michael H. Antoni, Hannah M. Fisher

Publikováno v: Cancer. 125:1717-1725

BACKGROUND Women with breast cancer (BCa) experience heightened distress, which is related to greater inflammation and poorer outcomes. The s100 protein family facilitates the inflammatory response by regulating myeloid cell function through the bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ffbeeeffa62bcdcfb2eed19c601a6b7
https://doi.org/10.1002/cncr.31965

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Abstract P3-06-01: Therapeutic targeting of RAGE in the tumor and tumor microenvironment inhibits breast progression and metastasis

Autor: Ayse Ergonul, Joyce M. Slingerland, Katherine Drews-Elger, Gyong Ha Hwang, Dorraya El-Ashry, A. Braley, Barry I. Hudson, Tae Kyoung Kwak, Marc E. Lippman

Publikováno v: Cancer Research. 77:P3-06

Background: The Receptor for Advanced-Glycation End-products (RAGE) is highly expressed in various cancers and its expression is correlated with poorer outcomes in breast cancer. We have previously implicated RAGE in breast cancer, but whether RAGE d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::742f2ba5296dee61fb7e5df3092f704a
https://doi.org/10.1158/1538-7445.sabcs16-p3-06-01

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Abstract P2-05-07: RAGE-ligand signaling drives breast cancer metastasis through affecting cells of the tumor and microenvironment

Autor: Tae Kyoung Kwak, Marc E. Lippman, Alexandra H. Besser, Dekuang Zhao, Joyce M. Slingerland, Barry I. Hudson, Katherine Drews-Elger, Ayse Ergonul

Publikováno v: Cancer Research. 76:P2-05

Breast cancer is most common malignant state in women, with 20% of these patients developing metastasis during the course of their disease. Further understanding is needed of the process and mechanisms of metastasis. Our lab and others have been show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f981070133227cfc548d5632271db2c2
https://doi.org/10.1158/1538-7445.sabcs15-p2-05-07

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Abstract B41: BRAF targeting sensitizes resistant melanoma to cytotoxic T cells

Autor: Tae Kyoung Kwak, Michael J. Schell, Allison Richards, Amod A. Sarnaik, Jane L. Messina, Shari Pilon-Thomas, Cigdem Atay, Jeffrey S. Weber, Meenhard Herlyn, Vito W. Rebecca, Valerie Moberg, Dmitry I. Gabrilovich, Gao Zhang, Sergio Lavilla-Alonso

Publikováno v: Cancer Immunology Research. 8:B41-B41

Although treatment of combination therapy with BRAF and MEK inhibitors in patient with melanoma has shown longer duration of response and higher rate of tumor responses, recurrence of tumor from dual targeted therapy in patients with metastatic melan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be8dd13f48c78ae46fce6aeea9796ff6
https://doi.org/10.1158/2326-6074.tumimm18-b41

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Abstract P3-01-11: Targeting RAGE inhibits breast cancer invasion and metastasis

Autor: Barbara Mera, Melinda Magna, Gyong Ha Hwang, Toni M. Yeasky, Thuy-Mai Le, Tae Kyoung Kwak, Barry I. Hudson, Lucas Outcault, Masaru Takabatake, Marc E. Lippman

Publikováno v: Cancer Research. 80:P3-01

Background: Breast cancer (BC) is treatable with early detection, but once metastasis occurs, there is no cure. Therefore, it is of upmost importance to find targetable biomarkers that are involved in modulating the multi-step metastatic process. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af29506413ff0edc40e8ecfa90f0d938
https://doi.org/10.1158/1538-7445.sabcs19-p3-01-11

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Abstract # 3145 Rage-associated S100a8/A9 levels associated with circulating proinflammatory cytokines and social well-being in patients with breast cancer over the first 12 months of treatment

Autor: Barry I. Hudson, Bonnie B. Blomberg, Marc E. Lippman, C. Taub, Suzanne C. Lechner, Hannah M. Fisher, Michael H. Antoni, Tae Kyoung Kwak, Charles S. Carver, Erica R. Nahin, Alain Diaz, Gyong Ha Hwang

Publikováno v: Brain, Behavior, and Immunity. 76:e29

Inflammation and social adversity have been linked to poorer long-term outcomes in breast cancer (BCa) patients, whereas greater social and family well-being (sfwb) relates to less inflammation and longer disease-free interval in BCa. S100A8A9 is a R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a8519438945089b70060302f124f7f5
https://doi.org/10.1016/j.bbi.2018.11.264

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Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function*

Autor: Barry I. Hudson, Evis Harja, Ralf Landgraf, Joel Jules, Tae Kyoung Kwak, A. Braley

The receptor for advanced glycation end products (RAGE) is a multiligand transmembrane receptor that can undergo proteolysis at the cell surface to release a soluble ectodomain. Here we observed that ectodomain shedding of RAGE is critical for its ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0321739f8cc9e74ef8e612b0d56150
https://europepmc.org/articles/PMC4933258/

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