Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Tae Kyo Park"'
Autor:
Jina Song, Hyang Sook Lee, Beomseok Seo, Sun-Young Kim, Suho Park, Donghoon Seo, Okku Park, Doohwan Jung, Jongun Cho, Sanghyeon Yun, Jaeho Lee, Ha Jihyeon, Sangkwang Lee, Minah Seol, Tae Kyo Park, Kim Sena
Publikováno v:
Bioconjugate Chemistry. 31:1392-1399
Recently we have reported that the ortho-hydroxy-protected aryl sulfate (OHPAS) system can be exploited as a new self-immolative group (SIG) for phenolic payloads. We extended the system to nonphenolic payloads by simply introducing a para-hydroxy be
Autor:
Beomseok Seo, Hyang Sook Lee, Sun-Young Kim, Sanghyeon Yun, Suho Park, Okku Park, Sangkwang Lee, Jaeho Lee, Jongun Cho, Tae Kyo Park, Donghoon Seo, Doohwan Jung, Sung Ho Woo
Publikováno v:
Bioconjugate chemistry. 30(7)
A new self-immolative linker motif, Ortho Hydroxy-Protected Aryl Sulfate (OHPAS), was devised, and OHPAS-containing antibody drug conjugates (ADC) were tested in vitro and in vivo. Conveniently synthesized using Sulfur Fluorine Exchange (SuFEx) chemi
Autor:
Kim Sena, Jongun Cho, Okku Park, Sanghyeon Yun, Minah Seol, Tae Kyo Park, Jaeho Lee, Sangkwang Lee, Doohwan Jung, Donghoon Seo, Suho Park, Sung Ho Woo, Sun-Young Kim, Beomseok Seo, Hyang Sook Lee
Publikováno v:
Bioconjugate chemistry. 30(7)
The ortho-hydroxy-protected aryl sulfate (OHPAS) linker is composed of a diaryl sulfate backbone equipped with a latent phenol moiety at the ortho position of one of the aryl units. The Ar–OH released when the ortho phenol undergoes intramolecular
Autor:
Yong Ju Kim, Nam Sook Kang, Tae Kyo Park, Jinyeong Kim, Myeong Hwi Lee, Park Kyung Eun, Hyoungrae Kim, Ho Young Song
Publikováno v:
Bulletin of the Korean Chemical Society. 37:1105-1113
Factor XIa (FXIa) is an enzyme that is activated during the earliest stage of initiation of the intrinsic pathway of the blood coagulation mechanism. In this study, we attempted to discover a new FXIa inhibitor based on structure-based molecular mode
Autor:
Sang Kyu Ye, Byung Hak Kim, Tae Kyo Park, Chung-Hyun Cho, Jun Sub Choi, Gou Young Koh, Junyeop Lee, Ho Young Song, Choun Ki Joo, Daeyoung Park, Tae-Yoon Kim
Publikováno v:
British Journal of Pharmacology. 172:3875-3889
Background and Purpose Abnormally induced angiogenesis and lymphangiogenesis are associated with human diseases, including neovascular eye disease. Substances that inhibit these processes may have potential as an attractive therapeutic strategy for t
Autor:
Kim Sunyoung, Beom-Seok Yang, Tae Kyo Park, Seung Hee Jung, Jong Un Cho, Hyang Sook Lee, Xiaoyan Sun, Trong Nhat Phan, Sung Ho Woo
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 340:510-519
Wound healing generally induces an inflammatory response associated with tissue fibrosis in which activated macrophage and myofibroblast cells are primarily involved. Although this is known to be the underlying mechanism for scarring and various fibr
Autor:
Byung-Hak, Kim, Junyeop, Lee, Jun-Sub, Choi, Dae Young, Park, Ho Young, Song, Tae Kyo, Park, Chung-Hyun, Cho, Sang-Kyu, Ye, Choun-Ki, Joo, Gou Young, Koh, Tae-Yoon, Kim
Publikováno v:
British journal of pharmacology. 172(15)
Abnormally induced angiogenesis and lymphangiogenesis are associated with human diseases, including neovascular eye disease. Substances that inhibit these processes may have potential as an attractive therapeutic strategy for these diseases.In vitro
Autor:
Govindaswami Ragupathi, David Live,⊥,‖ and, Hyunjin M. Kim, † Tae-Kyo Park, Andrzej Zatorski, Philip O. Livingston, Samuel J. Danishefsky, Prashant P. Deshpande
Publikováno v:
Journal of the American Chemical Society. 120:1600-1614
A concise and potentially practical synthesis of the title compound has been achieved. The route features a high degree of convergence and economy of synthetic operations. A key step is the concurrent introductory addition of three α-l-fucosyl resid
Autor:
In Jong Kim, Shengle Zhang, Govindaswami Ragupathi, Sucharita Adluri, Philip O. Livingston, Tae Kyo Park, Samuel J. Danishefsky, Kenneth O. Lloyd, Linda Graber
Publikováno v:
Angewandte Chemie International Edition in English. 36:125-128
Autor:
Tae Kyo Park, Shengle Zhang, Linda Graber, In Jong Kim, Philip O. Livingston, Govindaswami Ragupathi, Sucharita Adluri, Kenneth O. Lloyd, Samuel J. Danishefsky
Publikováno v:
Angewandte Chemie. 109:66-69