Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Tae Hwan Kwak"'
Autor:
Mai Tuyet Nguyen, Min-Ah Lee, Young-Kook Kim, Hyun Kook, Dongtak Jeong, Seung Pil Jang, Tae Hwan Kwak, Woo Jin Park
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0269735 (2022)
We previously showed that the matricellular protein CCN5 reverses established cardiac fibrosis (CF) through inducing apoptosis in myofibroblasts (MyoFBs) but not in cardiomyocytes or fibroblasts (FBs). In this study, we set out to elucidate the molec
Externí odkaz:
https://doaj.org/article/6b4a6b12e385430883a47dbcb93f3945
Autor:
AiHua Shen, Hyung-Jin Kim, Gi-Su Oh, Su-Bin Lee, Seung Hoon Lee, Arpana Pandit, Dipendra Khadka, Seong-Kyu Choe, Sung Chul Kwak, Sei-Hoon Yang, Eun-Young Cho, Hyun-Seok Kim, Hail Kim, Raekil Park, Tae Hwan Kwak, Hong-Seob So
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Acute pancreatitis (AP) is a complicated disease without specific drug therapy. The cofactor nicotinamide adenine dinucleotide (NAD+) is an important regulator of cellular metabolism and homeostasis. However, it remains unclear whether modul
Externí odkaz:
https://doaj.org/article/a7012ccbdf9e48b2bfc3a7ac7980c0c4
Autor:
Sergiy Velychko, Kyuree Kang, Sung Min Kim, Tae Hwan Kwak, Kee-Pyo Kim, Chanhyeok Park, Kwonho Hong, ChiHye Chung, Jung Keun Hyun, Caitlin M. MacCarthy, Guangming Wu, Hans R. Schöler, Dong Wook Han
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 30-39.e4 (2019)
Summary: Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). Howe
Externí odkaz:
https://doaj.org/article/ae90a700c247457aa7cef3a294166ccf
Autor:
Seon In Hwang, Tae Hwan Kwak, Ji Hyun Kang, Jonghun Kim, Hyunseong Lee, Kee-Pyo Kim, Kinarm Ko, Hans R. Schöler, Dong Wook Han
Publikováno v:
Stem Cells International, Vol 2019 (2019)
We previously described the generation of induced hepatocyte-like cells (iHeps) using the hepatic transcription factor Hnf1a together with small molecules. These iHeps represent a hepatic state that is more mature compared with iHeps generated with m
Externí odkaz:
https://doaj.org/article/28ac5f0f5ff1484e9d31ae5dd7ccf5c9
Autor:
Kyung Tae Lim, Seung Chan Lee, Yimeng Gao, Kee-Pyo Kim, Guangqi Song, Su Yeon An, Kenjiro Adachi, Yu Jin Jang, Jonghun Kim, Kyoung-Jin Oh, Tae Hwan Kwak, Seon In Hwang, Jueng Soo You, Kinarm Ko, Seung-Hoi Koo, Amar Deep Sharma, Jong-Hoon Kim, Lijian Hui, Tobias Cantz, Hans R. Schöler, Dong Wook Han
Publikováno v:
Cell Reports, Vol 15, Iss 4, Pp 814-829 (2016)
Recent studies have shown that defined factors could lead to the direct conversion of fibroblasts into induced hepatocyte-like cells (iHeps). However, reported conversion efficiencies are very low, and the underlying mechanism of the direct hepatic r
Externí odkaz:
https://doaj.org/article/3bb0855578b848449a9046f2debd0690
Autor:
Sung Min Kim, Kyung Tae Lim, Tae Hwan Kwak, Seung Chan Lee, Jung Hyun Im, Sai Hali, Seon In Hwang, Dajeong Kim, Jeongho Hwang, Kee-Pyo Kim, Hak-Jae Chung, Jeong Beom Kim, Kinarm Ko, Hyung-Min Chung, Hoon Taek Lee, Hans R. Schöler, Dong Wook Han
Publikováno v:
Stem Cell Research, Vol 16, Iss 2, Pp 460-468 (2016)
Somatic cells could be directly converted into induced neural stem cells (iNSCs) by ectopic expression of defined transcription factors. However, the underlying mechanism of direct lineage transition into iNSCs is largely unknown. In this study, we e
Externí odkaz:
https://doaj.org/article/93feecc305a741498541c432728a8faa
Autor:
Jihwa Kim, Sanghyun Joo, Gwang Hyeon Eom, Seung Hoon Lee, Min-Ah Lee, Miyoung Lee, Ki Woo Kim, Do Han Kim, Hyun Kook, Tae Hwan Kwak, Woo Jin Park
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207228 (2018)
Obesity is associated with various human disorders, such as type 2 diabetes, cardiovascular diseases, hypertension, and cancers. In this study, we observed that knockout (KO) of CCN5, which encodes a matricellular protein, caused mild obesity in mice
Externí odkaz:
https://doaj.org/article/6c62b3db7ec848db9e4dfdc2362d68f1
Autor:
Toru Yamashita, Wentao Liu, Yoshiaki Matsumura, Ryosuke Miyagi, Yun Zhai, Momoko Kusaki, Nozomi Hishikawa, Yasuyuki Ohta, Sung Min Kim, Tae Hwan Kwak, Dong Wook Han, Koji Abe M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 26 (2017)
Somatic cells can be directly converted into induced neural stem cells (iNSCs) by defined transcription factors. However, the therapeutic effect of undifferentiated iNSCs on ischemic stroke has not been demonstrated. In this study, we used a mouse mo
Externí odkaz:
https://doaj.org/article/9cdccb674eb84c699c3bf0c6b2f9e955
Autor:
Joo-Won Lee, Sung Sik Choe, Hagoon Jang, Jiyeong Kim, Hyun Woo Jeong, Hyunsun Jo, Kyeong-Hoon Jeong, Surendar Tadi, Myoung Gyu Park, Tae Hwan Kwak, Jin Man Kim, Dong-Hoon Hyun, Jae Bum Kim
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 7, Pp 1277-1286 (2012)
In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. In several obese rodent models, glabridin decreased body weight and adiposity with a concomitant r
Externí odkaz:
https://doaj.org/article/f4cd700eb44d47c1b2825186c6479053
Autor:
Moon Hee Jeong, Nguyen Khoi Song Tran, Tae Hwan Kwak, Byung Keon Park, Chul Soon Lee, Tae-Sik Park, Young-Hoon Lee, Woo Jin Park, Dong Kwon Yang
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91039 (2014)
Lipotoxic cardiomyopathy is caused by myocardial lipid accumulation and often occurs in patients with diabetes and obesity. This study investigated the effects of β-lapachone (β-lap), a natural compound that activates Sirt1 through elevation of the
Externí odkaz:
https://doaj.org/article/82dadf231e9f4dcfaa3557be20b557d4