Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tadeusz P. Karcz"'
Autor:
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jürgen Wess, Kenneth A. Jacobson
Publikováno v:
JCI Insight, Vol 6, Iss 10 (2021)
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance, which can ultimately lead to the development of T2D. F
Externí odkaz:
https://doaj.org/article/415ac4152bc74c40af64da7ddcf8b9cd
Autor:
Zhiwei, Wen, Veronica, Salmaso, Young-Hwan, Jung, Ngan B, Phung, Varun, Gopinatth, Qasim, Shah, Alexandra T, Patterson, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, David I, Lieberman, Gregory S, Whitehead, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
High affinity phenyl-piperidine P2Y(14)R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopenty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da62c41535c927994c70d1b42266cae7
https://pubmed.ncbi.nlm.nih.gov/35113556
https://pubmed.ncbi.nlm.nih.gov/35113556
Autor:
Kenneth A. Jacobson, Donald N. Cook, Tadeusz P Karcz, John C R Randle, John M. Bennett, Varun Gopinatth, Zhiwei Wen, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, David I. Lieberman, Veronica Salmaso, Zhoumou Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:5099-5122
A known zwitterionic, heterocyclic P2Y14R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8619de0d7c2d74a8325f516dd55228e
https://doi.org/10.1021/acs.jmedchem.1c00164
https://doi.org/10.1021/acs.jmedchem.1c00164
Autor:
Zhiwei Wen, Veronica Salmaso, Young-Hwan Jung, Ngan B. Phung, Varun Gopinatth, Qasim Shah, Alexandra T. Patterson, John C. R. Randle, Zhoumou Chen, Daniela Salvemini, David I. Lieberman, Gregory S. Whitehead, Tadeusz P. Karcz, Donald N. Cook, Kenneth A. Jacobson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a16138dcf66e0cf8b0d97c43fac4e0
http://hdl.handle.net/11577/3459804
http://hdl.handle.net/11577/3459804
Autor:
Gregory S. Whitehead, Tadeusz P. Karcz, Dilip K. Tosh, Young-Hwan Jung, Zhiwei Wen, Ryan G. Campbell, Varun Gopinatth, Zhan-Guo Gao, Kenneth A. Jacobson, Donald N. Cook
COVID-19 disease is associated with progressive accumulation of SARS-CoV-2-specific mRNA, which is recognized by innate immune receptors, such as TLR3. This in turn leads to dysregulated production of multiple cytokines, including IL-6, IFN-γ, CXCL1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddab2d317b599110bf79f6e32515bd8
https://ruj.uj.edu.pl/xmlui/handle/item/303815
https://ruj.uj.edu.pl/xmlui/handle/item/303815
Autor:
Ken Jacobson, Donald N. Cook, Mirko Scortichini, Sai Prasad Pydi, Oksana Gavrilova, Efrat L Kesner, Young-Hwan Jung, Tadeusz P Karcz, Jürgen Wess, Shanu Jain
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170a36868db8a95bfb267ce03b654b97
https://doi.org/10.1096/fasebj.2021.35.s1.02001
https://doi.org/10.1096/fasebj.2021.35.s1.02001
Autor:
Young-Hwan Jung, Sai Prasad Pydi, Jürgen Wess, Efrat L Kesner, Tadeusz P Karcz, Shanu Jain, Mirko Scortichini, Kenneth A. Jacobson, Oksana Gavrilova, Donald N. Cook
Publikováno v:
JCI Insight
Obesity is the major driver of the worldwide epidemic in type 2 diabetes (T2D). In the obese state, chronically elevated plasma free fatty acid levels contribute to peripheral insulin resistance, which can ultimately lead to the development of T2D. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac55fa96e124f3dc71a03e8fa72e7bc
http://europepmc.org/articles/PMC8262345
http://europepmc.org/articles/PMC8262345
Autor:
Young-Hwan, Jung, Veronica, Salmaso, Zhiwei, Wen, John M, Bennett, Ngan B, Phung, David I, Lieberman, Varun, Gopinatth, John C R, Randle, Zhoumou, Chen, Daniela, Salvemini, Tadeusz P, Karcz, Donald N, Cook, Kenneth A, Jacobson
Publikováno v:
J Med Chem
A known zwitterionic, heterocyclic P2Y(14)R antagonist 3a was substituted with diverse groups on the central phenyl and terminal piperidine moieties, following a computational selection process. The most potent analogues contained an uncharged piperi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2538a8e3308d6a52460a78072272a801
https://pubmed.ncbi.nlm.nih.gov/33787273
https://pubmed.ncbi.nlm.nih.gov/33787273
Autor:
Leesa J. Deterding, Sara A. Grimm, Donald N. Cook, Jason Williams, Gregory S. Whitehead, Tadeusz P Karcz, Keiko Nakano, Hideki Nakano, Kenneth A. Jacobson
Publikováno v:
J Clin Invest
Airway eosinophilia is a hallmark of allergic asthma and is associated with mucus production, airway hyperresponsiveness, and shortness of breath. Although glucocorticoids are widely used to treat asthma, their prolonged use is associated with severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3aa73acd8bf5689d23ffa4c3f65510
https://europepmc.org/articles/PMC8011887/
https://europepmc.org/articles/PMC8011887/
Autor:
Steven Dudas, Zhan-Guo Gao, Jinha Yu, Zhiwei Wen, Tadeusz P Karcz, John M. Bennett, Kenneth A. Jacobson, Sierra Duca, Ngan B. Phung, Daniela Salvemini, Young-Hwan Jung, Veronica Salmaso, Donald N. Cook, Zhoumou Chen
Publikováno v:
J Med Chem
Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y(14) receptor (P2Y(14)R) antagonists were synthesized, and affinity was measured in P2Y(14)R-expressing Chinese hamster ovary cells by flow cytometry. Given this series’ l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e1e7f295e8914ed6cd6052e64fe4cb
https://europepmc.org/articles/PMC8040948/
https://europepmc.org/articles/PMC8040948/